A5007108562- Central Venous Catheters and Hemodialysis
- Venous Thromboembolism Diagnosis and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Vascular Procedures and Complications
- Bladder and Urothelial Cancer Treatments
- Diagnosis and Treatment of Venous Diseases
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Biliary and Gastrointestinal Fistulas
- Liver Disease and Transplantation
- Satellite Image Processing and Photogrammetry
- Gallbladder and Bile Duct Disorders
- Advanced MRI Techniques and Applications
- Molecular Biology Techniques and Applications
- NF-κB Signaling Pathways
- Immunotherapy and Immune Responses
- Urinary and Genital Oncology Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Computational Drug Discovery Methods
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Heat shock proteins research
- Plant-derived Lignans Synthesis and Bioactivity
- Mechanisms of cancer metastasis
- Ginger and Zingiberaceae research
Yangtze University
2013-2025
The First Affiliated Hospital, Sun Yat-sen University
2017-2023
Sun Yat-sen University
2013-2023
First People's Hospital of Jingzhou
2010-2020
Renmin Hospital of Wuhan University
2020
Chinese PLA General Hospital
2011-2014
Hainan Branch of People's Liberation Army General Hospital
2014
PLA Information Engineering University
2013
Third Affiliated Hospital of Sun Yat-sen University
2013
Nankai University
2008
Although immunotherapy of hepatocellular carcinoma using immune checkpoint inhibitors has achieved certain success, only a subset patients benefits from this therapeutic strategy. The combination immunostimulatory chemotherapeutics represents promising strategy to enhance the effectiveness immunotherapy. However, it is hampered by poor delivery conventional chemotherapeutics. Here, shown that H-ferritin nanocages loaded with doxorubicin (DOX@HFn) show potent chemo-immunotherapy in tumor...
The purpose of the present study was to evaluate technical feasibility and safety sharp recanalization for central venous occlusive disease (CVOD) in patients requiring hemodialysis.Patients with CVOD hemodialysis who had undergone endovascular using devices, including stiff end a guidewire, Chiba needle, or RUS-100 cross occluded segments after conventional techniques failed were included. needle guided toward target placed at opposite occlusion. Although guidewire passed though occlusion,...
Osteoarthritis (OA) is a chronic degenerative joint disorder. Previous studies have shown abnormally increased apoptosis of chondrocytes in patients and animal models OA. TNF-α nitric oxide been reported to induce chondrocyte ageing; however, the mechanism induced by IL-1β has remained unclear. The aim this study identify role c-Jun N-terminal kinase (JNK) - pathway regulating induction Bim, its implication apoptosis. This showed that Bim upregulated obtained from articular cartilage OA...
To compare the clinical effects of three minimally invasive surgeries on treatment impacted upper ureteral calculi.135 patients with calculi were selected and randomly divided into groups (Group A-C) (n=45), which treated transurethral ureteroscopic lithotripsy, percutaneous nephrolithotomy, retroperitoneal laparoscopic ureterolithotomy respectively. Relevant results compared.The surgery time Group C was significantly longer than those A B (P < 0.05). The postoperative hospitalization 37.78%...
Evaluate the efficacy and safety of transarterial chemoembolization (TACE) sequential with hepatic arterial infusion chemotherapy (HAIC) a tyrosine kinase inhibitor (TKI) for unresectable large hepatocellular carcinoma (HCC).Patients HCC size > 70 mm were included. They received 1-3 cycles TACE HAIC every 3-6 weeks 2-6 cycles, each cycle given over period 48 hours (oxaliplatin plus fluorouracil/leucovorin). Patients also sorafenib or lenvatinib beginning at first continuing until disease...
A versatile UCST-type composite microsphere for image-guided chemoembolization and photothermal therapy to enhance therapeutic response of liver cancer.
The marginal division (MrD) is a neostriatum subregion that links the limbic system and basal nucleus of Meynert; it an important subcortical center involved in learning memory. Alzheimer's disease (AD) neurodegenerative disorder most common cause dementia elderly. AD clinically manifests as gradually progressive cognitive decline with behavioral disorders. Prior to full dementia, patients typically experience transient state, i.e., mild impairment (MCI). Amnestic MCI individuals, but not...
Identifying patients at high risk of developing chronic postsurgical pain (CPSP) is extreme importance in order to help launch appropriate therapeutic strategies and intensive initiation management. In this study, we aimed conduct a multi-center retrospective cohort study establish prognostic model nomogram predict the risks CPSP elderly who underwent hip arthroplasty 6 months postoperatively. We collected data from 736 aged >65 years had undergone October 1, 2016 September, 30, 2018...
The study purpose was to determine the outcomes and factors predictive of primary stent patency for treatment central venous occlusive disease (CVOD) in hemodialysis patients.Data 71 patients with CVOD treated placement from January 2012 December 2017 were analyzed. Univariate multivariate analysis performed associated patency. Adverse events related also examined.The median duration 16 ± 2.2 months. cumulative 3-, 6-, 9-, 12- month rates 93%, 72%, 55%, 51%, respectively. Independent...
Objective: Our objective was to evaluate the feasibility of XperCT combined fluoroscopy guide sharp recanalization for treatment chronic thoracic venous occlusive disease in hemodialysis patients. Methods: The records patients with who received endovascular after conventional techniques failed were retrospectively reviewed. devices used included stiff end a guidewire, Chiba biopsy needle, RUPS-100 set, and transseptal needle. needle advanced toward target placed at opposite occlusion guided...
Microwave ablation (MWA) is an effective treatment for liver cancer (LC), but its impact on distant tumors remains to be fully elucidated. This study investigated the abscopal effects triggered by MWA of LC, at different power levels and with or without combined immune checkpoint inhibition (ICI). We established a mouse model bilateral subcutaneous LC applied varied ablate right-sided tumor, immunotherapy. Left-sided tumor growth was monitored assess effect. Immune cell infiltration...
Objectives: To explore the clinical effect and safety of laparoscopic radical cystectomy + orthotopic ileal neobladder open surgery.
 Methods: The study was conducted at Jingzhou First People’s Hospital from January 2017 to July 2018. In this 87 patients undergoing were chosen classified into an observation group (48 cases) a control (39 according surgical methods. underwent surgery, while surgery. Perioperative period prognostic conditions compared in both groups.
 Results:...
Big mitogen‑activated protein kinase 1 [also named extracellular signal‑regulated (ERK) 5] is activated by mitogens and oncogenic signals strongly implicated in tumorigenesis. Our previous investigation indicated that ERK5 can induce prostatic carcinoma cell proliferation promoting entry into the S phase of cycle. In present study, microarray western blot analysis revealed inhibit Ras‑like oestrogen‑regulated growth inhibitor (RERG) expression inhibition RERG promotes migration. addition,...
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. Emerging evidence has revealed the vital functions microRNAs (miRNAs) in cancer malignant progressions. miR-375 been verified to serve as an antioncogene tumorigenesis and potential therapeutic target various types cancer. In this study, we aimed determine role regulation chemoresistance metastasis HCC. Differentially expressed NCAPG2 were externally validated using expression data from The Cancer Genome...
This study aims to investigate the association between clinical factors of patients with central (superior vena cava, brachiocephalic, or subclavian) venous occlusion stenosis (CVO/CVS) and difficulty interventional recanalization as well duration postoperative patency.A total 103 hemodialysis CVO/CVS treated endovascular treatment were enrolled. The two-step cluster analysis was selected differentiate cases into distinct phenotypes automatically. Differences in characteristics,...
To investigate the optimal starting time point of sorafenib therapy in suppressing tumor-promoting effects VEGF up-regulation, which is frequently found after local clinical practice.VEGF was intravenously injected to imitate evaluated expression tumor therapy, such as TACE. A total 40 SD rats bearing hepatic tumors were randomly divided into four groups and administered at different timepoints: (A) control group: injection only; (B) initiating 72 h prior injection; (C) simultaneously with...
3055 Background: CVX-241 is a fusion protein comprised of recombinant humanized IgG1 scaffold designed to specifically and selectively fuse, via chemical linker, two engineered angiopoietin-2 (Ang2) binding vascular growth factor (VEGF) peptides. In preclinical studies, antiangiogenic decreases tumor proliferation. Methods: stage 1, pts with solid tumors received escalating doses in cohorts 3-6 at the following doses: 0.3, 3, 6, 12, 15 or 18 mg/kg. An additional are planned be treated...
Abstract Background It has not been demonstrated that computational fluid dynamics (CFD) can be used to model central venous stenosis (CVS), nor hemodynamic changes in CVS treated with stent placement anticipated. The purpose of this study was demonstrate the performance patients placement. Methods Patient‐specific geometric models were constructed using computed tomography images veins from hemodialysis CFD simulation based on geometry performed ANSYS‐15 compare pressure quantitatively,...