A5048148644- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- COVID-19 Impact on Reproduction
- Glioma Diagnosis and Treatment
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Lipid metabolism and biosynthesis
- Alcohol Consumption and Health Effects
- Immune responses and vaccinations
- Hepatocellular Carcinoma Treatment and Prognosis
- Social and Cultural Dynamics
- Death Anxiety and Social Exclusion
- Eating Disorders and Behaviors
- Psychological Well-being and Life Satisfaction
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Cardiac Health and Mental Health
- Protein Hydrolysis and Bioactive Peptides
- Social and Intergroup Psychology
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2025
China Executive Leadership Academy Pudong
2021-2024
Guilin Medical University
2019-2022
Institute of Geology and Geophysics
2016
Chinese Academy of Sciences
2016
Abstract The success of checkpoint inhibitors in cancer treatment is associated with the infiltration tissue-resident memory T (Trm) cells. In this study, we found that about 30% tumor-infiltrating lymphocytes (TIL) tumor microenvironment gastric adenocarcinoma were CD69+CD103+ Trm cells low patients metastasis, and presence was better prognosis adenocarcinoma. expressed high PD-1, TIGIT, CD39 represented tumor-reactive TILs. Instead utilizing glucose, relied on fatty acid oxidation for cell...
Aging is a natural aspect of mammalian life. Although cellular mortality inevitable, various diseases can hasten the aging process, resulting in abnormal or premature senescence. As cells age, they experience distinctive morphological and biochemical shifts, compromising their functions. Research has illuminated that senescence coincides with significant alterations microRNA (miRNA) expression profile. Notably, subset aging-associated miRNAs, originally encoded by nuclear DNA, relocate to...
The constrained cross-talk between myeloid cells and T in the tumor immune microenvironment (TIME) restricts cancer immunotherapy efficacy, whereas underlying mechanism remains elusive. Parkin, an E3 ubiquitin ligase renowned for mitochondrial quality control, has emerged as a regulator of response. Here, we show that both systemic macrophage-specific ablations Parkin mice lead to attenuated progression prolonged mouse survival. By single-cell RNA-seq flow cytometry, demonstrate deficiency...
Background The molecular characteristics of prostate cancer (PCa) cells and the immunosuppressive bone tumor microenvironment (TME) contribute to limitations immune checkpoint therapy (ICT). Identifying subgroups patients with PCa for ICT remains a challenge. Herein, we report that basic helix-loop-helix family member e22 (BHLHE22) is upregulated in metastatic drives an TME. Methods In this study, function BHLHE22 metastases was clarified. We performed immunohistochemical (IHC) staining...
Colorectal cancer (CRC), one of the most common malignant tumors worldwide, has a high mortality rate, especially for patients with CRC liver metastasis (CLM). However, CLM pathogenesis remains unclear.We integrated multiple cohort datasets and databases to clarify verify potential key candidate biomarkers signal transduction pathways in CLM. GEO2R, DAVID 6.8, ImageGP, STRING, UALCAN, ONCOMINE, THE HUMAN PROTEIN ATLAS, GEPIA 2.0, cBioPortal, TIMER DRUGSURV, CRN, GSEA 4.0.3, FUNRICH 3.1.3 R...
A versatile UCST-type composite microsphere for image-guided chemoembolization and photothermal therapy to enhance therapeutic response of liver cancer.
Alcoholic liver disease (ALD), with its increasing morbidity and mortality, has seriously extensively affected the health of people worldwide. Caffeic Acid Dimethyl Ether (CADE) significantly inhibits alcohol-induced hepatic steatosis in vivo through AMP-activated protein kinase (AMPK) pathway, but in-depth mechanism remains unclear. This work aimed to clarify further CADE improving lipid accumulation ALD microRNA-378b (miR-378b)-mediated Ca2+/calmodulin-dependent 2 (CaMKK2)-AMPK signaling...
Chromobox (CBX) 2, a member of the CBX protein family and crucial component polycomb repressive complex (PRC), exerts significant influence on epigenetic regulation tumorigenesis, including glioma. However, precise role CBX2 in glioma has remained elusive. In our study, we observed substantial upregulation expression glioma, which displayed strong correlation with pathological grade, chemoresistance, unfavorable prognosis. Through series vivo vitro experiments, established that heightened...
Insulin resistance has been implicated in alcoholic liver disease. A previous study shown that microRNAs (miRNAs) play a major role the production, secretion, and function of insulin. MiRNAs are capable repressing multiple target genes turn negatively regulate various physiological pathological activities. However, current information on biological miRNAs insulin is limited. The goal present was to elucidate miR-378b alcohol-induced hepatic its underlying mechanism. This observed...
Alcoholic liver disease (ALD) has seriously harmed the health of people worldwide, but its underlying mechanisms remain unclear. This study aims to clarify biological function microRNA-378b (miR-378b) in ethanol (EtOH)-induced hepatic lipid accumulation. Here, we report miR-378b is over-expressed EtOH-induced cells and EtOH-fed mice finally accelerates MiR-378b directly targets Ca
Chronic comorbidities are often associated with higher risks of depression and mortality. This study aims to explore the relationships between Charlson Comorbidity Index (CCI) depression, their combined effect on
Abstract Past research has associated materialism with lower well-being. However, on the effect of interpersonal trust and its underlying mechanism is limited. This investigated how dispositional situational relate to trust, as well mediation proposed based a social projection account (social self-referential heuristic in which individuals assume others share similar mental experiences them). Study 1 explored associations generalized particularistic trust. The results showed that could...
Non-small cell lung cancer (NSCLC) is the main pathological type of cancer. In this study, multi-omics analysis revealed a significant increase pseudouridine synthase 1 (PUS1) in NSCLC and high expression PUS1 was associated with shorter OS (Overall Survival), PFS (Progression Free PPS (Post Progression Survival) patients. Clinical subgroup showed that may be involved occurrence development NSCLC. Besides, TIMER, ESTIMATE, IPS suggested immune infiltration, significantly negatively...
Nowadays, most courses in massive open online course (MOOC) platforms are xMOOCs, which based on the traditional instruction-driven principle. Course lecture is still key component of course. Thus, analyzing lectures instructors xMOOCs would be helpful to evaluate quality and provide feedback researchers. The current study aimed portray styles MOOCs from perspective natural language processing. Specifically, 129 transcripts were downloaded two major MOOC platforms. Two semantic analysis...
Abstract Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor. Immunotherapy research has led to advances in its treatment, but further necessary identify effective biomarkers. This study investigated the expression, pathological and prognostic significance, protein interactions, pathway enrichment, immune microenvironment, correlations between regulators infiltration of cells, associations with drug resistance genes, chemosensitivity immune-related biomarker leupaxin...
Abstract Background: Oesophageal cancer is a prevalent malignant tumour globally, yet it often receives subpar treatment. Recent interest in immunotherapy has instilled hope for patients. However, further research necessary to comprehend the mechanisms and roles of effective biomarker oesophageal squamous carcinoma (ESCC). Methods: We investigated expression, pathological prognostic significance, protein interactions, pathway enrichment, immune microenvironment, correlations between...