A5100680371- Congenital limb and hand anomalies
- Orthopedic Surgery and Rehabilitation
- Reconstructive Surgery and Microvascular Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Antibiotic Resistance in Bacteria
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Fungal and yeast genetics research
- Pharmaceutical and Antibiotic Environmental Impacts
- Circular RNAs in diseases
- Plant Reproductive Biology
- Signaling Pathways in Disease
- Extracellular vesicles in disease
- Cleft Lip and Palate Research
- Synthesis of Organic Compounds
- Pancreatic and Hepatic Oncology Research
- Congenital Anomalies and Fetal Surgery
- Anodic Oxide Films and Nanostructures
- Antibiotics Pharmacokinetics and Efficacy
- Gut microbiota and health
- Bacillus and Francisella bacterial research
Shanghai Chest Hospital
2024
Shanghai Jiao Tong University
2016-2024
Chongqing University
2023
Peking University
2021-2023
Beijing Jishuitan Hospital
2023
Chongqing Cancer Hospital
2023
Guangxi Medical University
2021
Beijing Tian Tan Hospital
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Shanghai Ninth People's Hospital
2021
Although Klebsiella pneumoniae bloodstream infections (KP-BSIs) have recently attracted attention due to an alarming raise in morbidity and mortality, there been few reports on the epidemiology of KP-BSIs mainland China. We sought describe epidemiological, microbiological, clinical characteristics KP-BSIs, focusing risk factors carbapenem resistance patient mortality. A retrospective analysis WHONET data KP-BSI patients admitted a teaching hospital Shanghai, China, between January 1, 2011...
Breast cancer is the most prevalent tumor in women worldwide and about 70% patients are estrogen receptor positive. In these patients, resistance to anticancer antagonist tamoxifen emerges be a major clinical obstacle. Peptidyl-prolyl isomerase Pin1 prominently overexpressed breast involves tamoxifen-resistance. Here, we explore mechanism effect of targeting using its chemical inhibitor all-trans retinoic acid (ATRA) treatment tamoxifen-resistant cancer. We found that was up-regulated human...
The human gut microbiome is a reservoir for antibiotic resistance gene (ARG). Therefore, characterizing resistome distribution and potential disease markers can help manage antibiotics at the clinical level. While much population-level research has highlighted strong effect of donor geographic origin on ARG prevalence in gut, little known regarding effects other properties, such as age, sex, disease. Here we employed 2,037 fecal metagenomes from 12 countries. By quantifying genes 24 types...
Switching of Saccharomyces mating type by replacement sequences at the MAT locus involves a choice between two donors, HML and HMR. α cells inhibit recombination along entire left arm chromosome III, including HML, whereas activate this same region. -dependent activation depends on small, cis -acting DNA sequence designated enhancer (RE), located 17 kb centromere-proximal to HML. A comparison RE interchangeable cerevisiae carlsbergensis defines minimum 244 bp. activity is repressed in...
We treated 16 patients with 17 hypoplastic thumbs (eight Type IIIB and nine IV) using a non-vascularized fourth metatarsal transfer rotational flap multi-staged reconstruction. The average age at the first operation was 24 months. follow-up time 46 All achieved reasonable hand function were able to use reconstructed thumb grip small large objects. operated an Kapandji score of 6.7 pinch strength 0.9 kg. There two cases graft nonunion. parents are satisfied appearance donor foot. conclude...
An increasing number of studies have indicated that the abnormal expression certain long non-coding RNAs (lncRNAs) is linked to overall survival (OS) patients with lung adenocarcinoma (LUAD). The aim present study was establish an lncRNA signature predict LUAD. gene profiles and associated clinical information LUAD were downloaded from Cancer Genome Atlas database. cohort randomly sub-divided into training verification cohorts. Univariate Cox regression analysis performed on differentially...
Juvenile hyaline fibromatosis (JHF) is a rare recessive autosomal hereditary disorder characterized by papulonodular skin, gingival hyperplasia, flexural joint contractures, and osteolytic bone lesions. Worldwide, less than 70 cases have been reported. JHF thought to be of collagen metabolism which caused genomic sequence variations in the ANTXR2/CMG2 gene homogenous amorphous material fibrous tissue. most commonly diagnosed infants children 5 years. We report 28-month-old child...
Abstract Background Prostate cancer (PCa) is still a serious male malignant disease across the world. However, no exact pathogenesis had been explained. Although adenylosuccinate lyase (ADSL) gene was identified to be important in PCa early 1987, its comprehensive functions for have not presented. Methods The cBioPortal Cancer Genomics, Oncomine and GEO database were retrieved investigate associations between of ADSL PCa. Then, PC-3, DU145 C4-2B cell lines applied vitro experiments. RNA...
Pancreatic cancer is a highly heterogeneous disease, making prognosis prediction challenging. Altered energy metabolism to satisfy uncontrolled proliferation and metastasis has become one of the most important markers tumors. However, specific regulatory mechanism its effect on have not been fully elucidated.To construct prognostic polygene signature differentially expressed genes (DEGs) related lipid metabolism.First, 9 tissue samples from patients with pancreatic were collected divided...
Abstract DNA replication origins, specified by ARS elements in Saccharomyces cerevisiae, play an essential role the stable transmission of chromosomes. Little is known about evolution elements. We have isolated and characterized from a chromosome III recovered alloploid Carlsberg brewing yeast that has diverged its S. cerevisiae homeologue. The positions seven identified this carlsbergensis are conserved: they located intergenic regions flanked open reading frames homologous to those flank...
: Division of the pulmonary ligament is standard in lower lobectomies, but its application upper lobectomies remains controversial due to potential complications like atelectasis and bronchial kinking. This retrospective matched cohort study aimed evaluate efficacy safety resection for oncological purposes.
The treatment of Manske type IIIB and IV thumb hypoplasia remains controversial, parents increasingly expect to maintain the hypoplastic in preference a five-digit hand.[1,2] There has been recent increased number reports regarding reconstruction severe with use free metatarsal transfers (MTs). Tsujino et al[3] reconstructed non-vascularized 4th metatarsal, filled bone defect an iliac graft. Chow al[4] reported on hemi-width MT, which reduced not only sacrifice donor foot but also strength...
Abstract Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor. Immunotherapy research has led to advances in its treatment, but further necessary identify effective biomarkers. This study investigated the expression, pathological and prognostic significance, protein interactions, pathway enrichment, immune microenvironment, correlations between regulators infiltration of cells, associations with drug resistance genes, chemosensitivity immune-related biomarker leupaxin...
Abstract Background: Oesophageal cancer is a prevalent malignant tumour globally, yet it often receives subpar treatment. Recent interest in immunotherapy has instilled hope for patients. However, further research necessary to comprehend the mechanisms and roles of effective biomarker oesophageal squamous carcinoma (ESCC). Methods: We investigated expression, pathological prognostic significance, protein interactions, pathway enrichment, immune microenvironment, correlations between...
Abstract Background: Pollicization remains the default treatment for severe thumb hypoplasia, while metatarsal transfer is an effective choice metacarpal reconstruction, with competitive outcome of reconstructed thumb. However, rare researches focused on donor foot transfer. The purpose this study was to evaluate short-term after full-width Manske Type IIIB and IV hypoplasia. Methods: Fourteen patients hypoplasia were enrolled in study. A graft (vascularised, from second or non-vascularised,...