A5101794292- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Ultrasound and Hyperthermia Applications
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Cardiac Imaging and Diagnostics
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Sepsis Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Cardiomyopathy and Myosin Studies
- Long-Term Effects of COVID-19
- Colorectal Cancer Treatments and Studies
- FOXO transcription factor regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer therapeutics and mechanisms
- Advanced Proteomics Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
Tongji Hospital
2017-2023
Huazhong University of Science and Technology
2017-2023
China Shipbuilding Industry Corporation (China)
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2022
Xi'an Jiaotong University
2020-2022
This study aimed to explore the validation and diagnostic value of multiple right ventricle (RV) volumes functional parameters derived from a novel artificial intelligence (AI)-based three-dimensional echocardiography (3DE) algorithm compared cardiac magnetic resonance (CMR).A total 51 patients with broad spectrum clinical diagnoses were finally included in this study. AI-based RV 3DE was performed single-beat HeartModel mode within 24 hours after CMR. In entire population, ventricular...
Desmoglein-2 (DSG2), a desmosomal adhesion molecule, is found to be closely related tumorigenesis in recent years. However, the clinical value of DSG2 lung adenocarcinoma remains unclear.Real-time reverse transcription-quantitative polymerase chain reaction (qRT-PCR) was utilized detect expression 40 paired tissues and corresponding non-cancerous tissues. Data from The Cancer Genome Atlas (TCGA) Oncomine datasets were also downloaded analyzed. correlation between clinicopathological features...
The contribution of autophagy to cancer therapy resistance remains complex, mainly owing the discrepancy mechanisms in different therapy. However, potential autophagy-mediated icotinib have yet be elucidated.The effect was examined using a series vitro and vivo assays. results above were further verified biopsy specimens lung patients before after or gefitinib treatment.Icotinib increased ATG3, ATG5, ATG7 expression, but without affecting Beclin-1, VPS34 ATBG14 levels icotinib-resistant...
Lung cancer is one of the most common types malignancy worldwide. The prognosis lung poor, due to onset metastases. aim present study was examine metastasis-associated genes. To identify novel targets, our previous detected differentially expressed mRNAs and long non-coding RNAs between large-cell high-metastatic 95D cell line low-metastatic 95C by microarray assay. In study, these genes (DEGs) were analyzed via bioinformatics methods, including Gene Ontology functional analysis Kyoto...
Background: Previous studies suggested that myocardial work (MW) may identify abnormalities in the left ventricular (LV) function and establish a more sensitive index for LV dysfunction at early stage. This study aimed to explore value of global regional MW parameters predicting high-risk stable coronary artery disease (SCAD) patients with normal wall motion preserved function. Patients Methods: A total 131 patients, who were clinically diagnosed as SCAD function, finally included this...
Abstract Background We aimed to explore the correlation between blood lipids (high density lipoprotein cholesterol [HDL‐C] and apolipoprotein A1 [ApoA1]) epidermal growth factor receptor (EGFR) T790M mutation, as well its predictive role in clinical efficacy progression‐free survial (PFS) advanced non‐small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitors (EGFR‐TKI). Methods retrospectively collected information of 153 NSCLC harboring exon mutation receiving...
Long non-coding RNAs (lncRNAs) have been involved in occurrence and progression of multiple cancers. In the present study, we investigated role lncRNA Gm15290 proliferation invasion non-small cell lung cancer (NSCLC) cells. First, found that was markedly up-regulated tumor tissues from NSCLC patients lines, compared with adjacent normal line HBE respectively. Then, different concentrations pcDNA-Gm15290 expression vector siRNA were respectively transfected into A549 Our results showed...
Long non-coding RNAs (lncRNAs) have been involved in occurrence and progression of multiple cancers. In this study, weinvestigated the role lncRNA Gm15290 proliferation invasion non-small cell lung cancer (NSCLC) cells. First, we found that was markedly upregulated tumor tissues from NSCLC patients lines, compared with adjacent normal line HBE respectively. Then, different concentrations pcDNA-Gm15290 expression vector siRNA were respectively transfected into A549 Our results showed...
The upregulation of vascular cell adhesion molecule-1(VCAM-1) on endothelium plays a great role in the progression atherosclerosis (AS). In this study, ultrasound molecular imaging was performed to monitor inflammation injuries onset and with microbubbles targeted VCAM-1.Mice deficient for apolipoprotein E (ApoE-/-mice) high-cholesterol diet were studied as an age-dependent model atherosclerosis. At 8, 16, 24, 32 weeks age, contrast enhanced (CEU) proximal ascending aorta VCAM-1. Plaque...
An increasing number of studies have indicated that the abnormal expression certain long non-coding RNAs (lncRNAs) is linked to overall survival (OS) patients with lung adenocarcinoma (LUAD). The aim present study was establish an lncRNA signature predict LUAD. gene profiles and associated clinical information LUAD were downloaded from Cancer Genome Atlas database. cohort randomly sub-divided into training verification cohorts. Univariate Cox regression analysis performed on differentially...
Previously, we identified differentially expressed proteins, including ADFP, between lung adenocarcinoma (LAC) tissue and paired normal bronchioloalveolar epithelium. In this study, investigated the role of ADFP in LAC. levels serum patients with cancer benign diseases were measured by enzyme-linked immunosorbent assays (ELISA). shRNA was used to knock-down or overexpress A549 NCI-H1299 cells. The biological function its underlying mechanisms evaluated vivo vitro. highly patients, especially...
Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality morbidity rate LUAD remains high worldwide. The aim present study was to perform systematic investigation tumor microenvironment (TME) identify TME-related genes prognostic value patients with LUAD. Firstly, immune scores stromal from Cancer Genome Atlas were calculated using Estimation STromal Immune cells MAlignant Tumors Expression data...
Background: Coronavirus disease 2019 can result in myocardial injury the acute phase. However, information on late cardiac consequences of coronavirus (COVID-19) is limited. Methods: We conducted a prospective observational cohort study to investigate COVID-19. Standard echocardiography and strain assessment were performed, blood biomarkers tested 86 COVID-19 survivors 327 days (IQR 318-337 days) after recovery. Comparisons made with 28 age-matched sex-matched healthy controls 30 risk...
Objectives Multiple types of mediastinal masses, especially masses in the anterior mediastinum, may be encountered routine echocardiographic examinations for symptomatic or asymptomatic patients. The aim this study was to evaluate diagnostic value transthoracic echocardiography combined with contrast‐enhanced ultrasonography determining location, composition, and vascularization masses. Methods A retrospective analysis conducted on 48 consecutive patients who first had a diagnosis by...
Small cell lung cancer (SCLC) is highly aggressive and associated with a dismal prognosis. However, there are no clinically recognized biomarkers for early diagnosis. In this study, we used quantitative proteomics to build differential mitochondrial protein profiles that may be diagnosis investigated the pathogenesis of cancer.We cultured SCLC cells (NCI-H446) normal human bronchial epithelial (16-HBE); mitochondria were extracted purified using Percoll density gradient centrifugation....
In a previous study, total of 568 differentially expressed proteins including the signal peptidase SPC21 were identified from lung adenocarcinoma (LUAD) and paired normal tissues. this role in LUAD progression was investigated.The relationships protein-protein interaction network between samples adjacent tissues via String Pajek software, respectively. The expression levels hub protein analyzed 84 LUAD-normal immunohistochemistry. prognostic value mRNA investigated 478 patients TCGA GTEx...