A5001872349- Polish Historical and Cultural Studies
- Lung Cancer Diagnosis and Treatment
- European Politics and Security
- Lung Cancer Treatments and Mutations
- Social Issues in Poland
- Pleural and Pulmonary Diseases
- Labour Market and Migration
- Tracheal and airway disorders
- Education and Cultural Studies
- Language and Culture
- Polish Law and Legal System
- Parasitic Diseases Research and Treatment
- Polish Legal and Social Issues
- Economic and Fiscal Studies
- Polish socio-economic development
- Central European Literary Studies
- Renewable energy and sustainable power systems
- Banking Systems and Strategies
- Finance, Markets, and Regulation
- Globalization, Economics, and Policies
- Agricultural economics and policies
- Pectus Deformity Diagnosis and Treatment
- Intellectual Property Rights and Media
- Management and Organizational Practices
- Polish-Jewish Holocaust Memory Studies
Poznan University of Medical Sciences
2015-2024
Thoracic Surgery Foundation
2019
Centrum Onkologii
2013-2017
Abstract Genome-wide association studies have identified loci at 15q25 ( IREB2 ) and 4q22 FAM13A ), associated with lung cancer (LC) chronic obstructive pulmonary disease (COPD). The aim of our research was to determine the SNPs LC severe/very severe COPD patients. We examined variants (rs2568494, rs2656069, rs10851906, rs13180) (rs1903003, rs7671167, rs2869967) among 1.141 participants (468 LC, 149 COPD, 524 smoking controls). frequency minor rs2568494 AA genotype, higher in vs controls P =...
Lymphadenectomy is an essential part of complete surgical operation for non-small cell lung cancer (NSCLC). This retrospective, multicenter cohort study aimed to identify factors that influence the lymphadenectomy quality. Data were obtained from Polish Lung Cancer Study Group Database. The primary endpoint was lobe-specific mediastinal lymph node dissection (L-SMLND). included 4271 patients who underwent VATS lobectomy stage IA NSCLC, operated between 2007 and 2022. L-SMLND performed in...
Pulmonary aspergilloma is a difficult therapeutic problem due to the low effectiveness of conservative treatment and high surgical morbidity.To analyze early late results for pulmonary aspergilloma.From 2005 2015, 49 patients were treated surgically aspergilloma. Symptoms occurred in 85.7% cases, including recurrent hemoptysis 53%. A history immunosuppressive therapy or chemotherapy was noted 24.5% patients. Complex diagnosed 79.6% cases. Immunological test positive 10.2%, bronchoalveolar...
Pneumonectomy is a high-risk radical resection procedure, with bronchopleural fistula (BPF) being its most challenging and severe complication. This study aimed to assess the surgical risk factors impact of bronchial stump closure technique on incidence BPF.This single-center, cross-sectional medical records 455 post-pneumonectomy patients operated due non-small cell lung cancer (NSCLC) in 2006-2017. We analyzed following variables their influence occurrence BPF: operation side, techniques...
The pedicled intercostal muscle flap (IMF) is a high quality vascularized tissue commonly used to buttress the bronchial stump after pneumonectomy or anastomosis sleeve lobectomy in order prevent bronchopleural fistula formation. evaluation of viability difficult. aim this study was assessment application indicyanine green fluorescence for IMF perfusion.The included 27 patients (10 males and 17 females), mean age 62.6 years (47-77 years). Indocyanine (ICG) objective by near-infrared camera...
Abstract Background High-energy devices allow better vessel sealing compared with monopolar electrocautery and could improve the outcomes of surgical operations. The objective study was to compare tissue dissection by LigaSure™ device that electrocoagulation for thoracoscopic lobectomy lymphadenectomy. Methods This pragmatic, parallel group, prospective randomized controlled trial funded Medtronic External Research Program (ISR-2016–10,756) registered at www.clinicaltrials.gov (NCT03125798)....
Several genome-wide association studies (GWASs), have identified that FAM13A and IREB2 loci are associated with lung cancer, but the mechanisms by which these genes contribute to diseases susceptibility, especially in hypoxia context, unknown. Hypoxia has been as a major negative factor for tumor progression clinical observation. It suggested, lower oxygen tension, may modulate activity. However, role of response not explained. To precise response, we analyzed expression, cancer cells vitro...
<b>INTRODUCTION:</b> Radical surgical treatment is the preferred action for patients with early-stage non-small cell lung cancer (NSCLC). Qualification should consider a risk associated effect of comorbidities on general condition patient. The aim this article was an attempt to identify factors postoperative complications in treated NSCLC, special focus coexisting diseases.<br><b>METHODS:</b> A total 400 NSCLC were included retrospective study. incidence (including major according European...
Thoracoscopic (VATS) lobectomy after a decade of criticism is nowadays considered as technically feasible, safe and oncologically proper operation. This approach has some advantages over conventional thoracotomy like: less postoperative pain, shorter hospitalization, fewer complications, better tolerance adjuvant chemotherapy with comparable long-term survival rate. The VATS now generally accepted an important alternative to open in early-stage lung cancer.In the study we analyzed all...
Patients over 75 years of age, who, in addition, often have already exceeded the average life expectancy, Polish population on 77.4 years, are subject discussion concerning most appropriate choice treatment.To analyse long-term results elderly patients age with lung cancer who underwent curative pulmonary resection.166 aged from to 85 (mean: ±2.3) operated for non-small cell (NSCLC) were included this study. There 128 (77%) men and 38 (23%) women.Lobectomy, including bilobectomy, was...
The standard of care for patients with early-stage non-small cell lung cancer (NSCLC) is anatomical resection lymphadenectomy. This multicenter, retrospective, cohort study aimed to identify predictors 5-year survival in after thoracoscopic lobectomy stage IA NSCLC. included 1249 who underwent NSCLC between 17 April 2007, and December 28, 2016. rate equaled 77.7%. In the multivariate analysis, higher age (OR, 1.025, 95% CI: 1.002 1.048; p = 0.032), male sex 1.410, 1.109 1.793; 0.005),...
Minimally invasive video-assisted thoracic surgery (VATS) lobectomy has proved to be equal and in some aspects superior open T1 T2 lung cancers. Indications for VATS pneumonectomy however are still not clearly defined strictly limited. The minimally can undertaken patients with centrally located tumors without extended invasion of the large pulmonary vessels, chest wall, pericardium, mediastinal structures or proximal part main bronchus when sleeve resection is feasible (T2). We present a...
A case of laryngeal haemangioma in the subglottic region a six-month-old infant with severe dyspnea is described. The tumour was totally removed and tissue at site its insertion coagulated. Control examination after almost 7 years showed very good air passage through larynx normal functioning. results histopathologic are discussed detail.
Conversion of thoracoscopic lobectomy for lung cancer to thoracotomy can adversely affect short-term outcomes, but the impact on long-term outcomes is unknown. This study aimed identify risk factors conversion and determine influence treatment.This retrospective included 1002 consecutive patients with who underwent between 7 June 1999 17 July 2018. The groups without were compared in terms possible short- outcomes. survival was analysed by Kaplan-Meier method.Conversion done 105 (10.5%). On...
Klotho has been recently described as a carcinogenesis suppressor. Large cell neuroendocrine lung carcinoma (LCNEC) is rare, highly malignant neoplasm. In the light of increasing incidence tumours, biomarkers predicting survival are needed. We consider that might be one.We analysed records all patients diagnosed with LCNEC, atypical carcinoid and typical operated on in our institution between 2007 2015. Initially, we found 134 cases. Forty-six specimens were unattainable thus excluded from...
Objectives The aim of this study was to investigate the fluorine-18-fluorodeoxyglucose (18F-FDG) uptake on integrated PET [PET/computed tomography (CT)] images and its correlation with nestin expression in a series neuroendocrine lung tumours. As incidence tumours is rising, tools predicting diagnosis, outcome assisting selection treatment regimens are needed. Patients methods We reviewed records patients diagnosed large cell carcinoma, atypical carcinoid typical who were operated upon our...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Skrzypczak P, Roszak M, Kasprzyk Kopczyńska A, Gabryel Dyszkiewicz W. Pneumonectomy – permanent injury or still effective method of treatment? Early and long-term results quality life after pneumonectomy due to non- small cell lung cancer. Kardiochirurgia i Torakochirurgia Polska/Polish Journal Thoracic Cardiovascular Surgery. 2019;16(1):7-12. doi:10.5114/kitp.2019.82966. APA Skrzypczak, P., Roszak, M.,...
The NBN gene, also known as NBS1, is located on the chromosome band 8q21.3, and encodes a 754-amino acid-long protein named nibrin. This member of MRE1-RAD50-NBN nuclear complex, involved in numerous cell processes essential for maintaining genomic stability. Heterozygous variants including p.I171V, c.657del5 p.R215W, have been described risk factors development several malignancies. However, there no report regarding association these mutations with lung cancer thus far. Therefore, present...
We aimed to investigate the clinical significance of left lower paratracheal nodes (#4L) and their impact on survival in patients with left-sided lung cancer.This was a retrospective analysis prospective data. The study included 5369 who underwent surgery between 2005 2015. Six hundred fifty-nine #4L dissection (4LND+), 4710 did not (4LND-). Propensity score matching used minimize analytic error (659 vs 659).The percentage metastasis increased tumour size. Between pT2a pT2b, it nearly...