A5060052476- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pectus Deformity Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Research Studies
- Multiple and Secondary Primary Cancers
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Genetic factors in colorectal cancer
- Cardiac and Coronary Surgery Techniques
- Medical Imaging and Pathology Studies
- Myasthenia Gravis and Thymoma
- Neuroendocrine Tumor Research Advances
- Cardiac tumors and thrombi
- Cancer Cells and Metastasis
- Cardiac Ischemia and Reperfusion
- Metabolomics and Mass Spectrometry Studies
- Tracheal and airway disorders
- Transplantation: Methods and Outcomes
- Trauma Management and Diagnosis
- Cancer Diagnosis and Treatment
- Cardiovascular Issues in Pregnancy
- Advanced Chemical Sensor Technologies
Poznan University of Medical Sciences
2013-2024
Thoracic Surgery Foundation
2019
Centrum Onkologii
2013-2017
Poznań University of Technology
2015
Greater Poland Cancer Center
2006
Internet Society
2004
United States Congress
2004
Heliodor Swiecicki Clinical Hospital
2004
Institute of Cardiology
2000-2003
KU Leuven
1988-1990
The aim of the project was to apply ultra-high-performance liquid chromatography-quadrupole-Orbitrap-high-resolution mass spectrometry for serum metabolite profiling non-small-cell lung cancer (NSCLC). This Orbitrap-based methodology has been applied a study NSCLC potential markers first time.After extraction using protein precipitation, sera were separated on ACE Excel 2 C18-PFP (100 × 2.1 mm, 2.0 µm) column gradient elution and analyzed within range 70-1000 m/z. Only patients with early...
Tobacco smoking is the main etiological factor of lung cancer (LC), which can also cause metabolome disruption. This study aimed to investigate whether observed metabolic shift in LC patients was associated with their status. Untargeted metabolomics profiling applied for initial screening changes serum profile between and chronic obstructive pulmonary disease (COPD) patients, selected as a non-cancer group. Differences metabolite profiles current former smokers were tested. Then, targeted...
Abstract Genome-wide association studies have identified loci at 15q25 ( IREB2 ) and 4q22 FAM13A ), associated with lung cancer (LC) chronic obstructive pulmonary disease (COPD). The aim of our research was to determine the SNPs LC severe/very severe COPD patients. We examined variants (rs2568494, rs2656069, rs10851906, rs13180) (rs1903003, rs7671167, rs2869967) among 1.141 participants (468 LC, 149 COPD, 524 smoking controls). frequency minor rs2568494 AA genotype, higher in vs controls P =...
The ability of early lung cancer diagnosis is an unmet need in clinical practice. Lung metabolomic analyses conducted so far have demonstrated several abnormalities lipid profile providing a rationale for further study blood lipidome the patients. In present research, we performed targeted screening to select molecules that show promise detection. was on serum samples collected from newly diagnosed, stage I non-small cell (NSCLC) patients and non-cancer controls. A high-throughput mass...
The aim of this study was to analyze the early and long-term results simultaneous surgical treatment both coronary heart disease (CHD) lung cancer.Twenty-five patients with diagnoses non-small cell cancer (NSCLC) unstable angina were operated on between 2001 2006 in Department Cardiothoracic Surgery at University Medical Sciences Poznań, Poland. Myocardial revascularization performed simultaneously resection. mean patient age 63 years. majority (18 patients) male stage predominantly AJCC II....
Testing for the epidermal growth factor receptor (EGFR) gene mutations requires considerable multidisciplinary experience of clinicians (for appropriate patient selection), pathologists selection cytological or histological material) and geneticists performing reporting reliable molecular tests). We present our on efficacy routine EGFR testing in various types tumor samples frequency a large series Polish non-small cell lung cancer (NSCLC) patients.Deletions exon 19 substitution L858R 21...
Objective: The aim of this study was to determine which the clinical parameters are most valuable in predicting postoperative atrial fibrillation after lung surgery. Materials and methods: Retrospective analysis carried out on 298 patients pulmonary resection necessitated mainly by cancer. following were investigated: age sex, disturbances cardiac rhythm, history ischemic heart disease, diabetes atherosclerosis, NYHA classification type surgical procedure. In addition, duration surgery,...
The surgical treatment of non-small cell lung cancer (NSCLC) in elderly patients presents a serious challenge to thoracic surgeons. As there is considerable divergence opinion about both the mortality and morbidity rates, it important set guidelines for proper patient selection.Early post-operative complications 42 aged over 70 years who had undergone pneumonectomy because NSCLC (Group I) were analyzed. control group II) consisted 48 patients, also years, but lobectomy or wedge resections....
We presented retrospective analysis of up to five polymorphisms in TS, MTHFR and ERCC1 genes as molecular predictive markers for homogeneous Caucasian, non-squamous NSCLC patients treated with pemetrexed platinum front-line chemotherapy. The following DNA isolated from 115 were analyzed: various number 28-bp tandem repeats 5′-UTR region TS gene, single nucleotide polymorphism (SNP) within the second repeat gene (G>C); 6-bp deletion 3′-UTR (1494del6); 677C>T SNP MTHFR; 19007C>T ERCC1....
Pulmonary aspergilloma is a difficult therapeutic problem due to the low effectiveness of conservative treatment and high surgical morbidity.To analyze early late results for pulmonary aspergilloma.From 2005 2015, 49 patients were treated surgically aspergilloma. Symptoms occurred in 85.7% cases, including recurrent hemoptysis 53%. A history immunosuppressive therapy or chemotherapy was noted 24.5% patients. Complex diagnosed 79.6% cases. Immunological test positive 10.2%, bronchoalveolar...
Pneumonectomy is a high-risk radical resection procedure, with bronchopleural fistula (BPF) being its most challenging and severe complication. This study aimed to assess the surgical risk factors impact of bronchial stump closure technique on incidence BPF.This single-center, cross-sectional medical records 455 post-pneumonectomy patients operated due non-small cell lung cancer (NSCLC) in 2006-2017. We analyzed following variables their influence occurrence BPF: operation side, techniques...
Twenty one patients with retained endocardial pacemaker leads were followed during a total observation period of 1097 months to assess the incidence complications. Two developed thrombosis and occlusion superior vena cava, which was relieved by development collateral venous circulation. In patient broken tip lead migrated pulmonary artery but did not cause overt The remaining free symptoms. One died for reasons unconnected treatment. good toleration most indicates that major surgical...
The pedicled intercostal muscle flap (IMF) is a high quality vascularized tissue commonly used to buttress the bronchial stump after pneumonectomy or anastomosis sleeve lobectomy in order prevent bronchopleural fistula formation. evaluation of viability difficult. aim this study was assessment application indicyanine green fluorescence for IMF perfusion.The included 27 patients (10 males and 17 females), mean age 62.6 years (47-77 years). Indocyanine (ICG) objective by near-infrared camera...
Due to high mortality rates of lung cancer, there is a need for identification new, clinically useful markers, which improve detection this tumor in early stage disease. In the current study, serum peptide profiling was evaluated as diagnostic tool non-small cell cancer patients. The combination ZipTip technology with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis pattern patients (n = 153) and control subjects 63) presented first time....
The following study presents a special independent atrial fibrillation (AF) risk factor—preoperative fluctuation of heart rate variability (HRV), as well other perioperative AF factors in patients qualified for pneumonectomy and undergoing or lobectomy lung cancer. prospective was performed who had undergone anatomical resection non-small-cell A total 117 (92 men 25 women) statistical research. In order to determine the factors, all were divided into two groups: Group A—98 without B—19 with...
Several genome-wide association studies (GWASs), have identified that FAM13A and IREB2 loci are associated with lung cancer, but the mechanisms by which these genes contribute to diseases susceptibility, especially in hypoxia context, unknown. Hypoxia has been as a major negative factor for tumor progression clinical observation. It suggested, lower oxygen tension, may modulate activity. However, role of response not explained. To precise response, we analyzed expression, cancer cells vitro...
<b>INTRODUCTION:</b> Radical surgical treatment is the preferred action for patients with early-stage non-small cell lung cancer (NSCLC). Qualification should consider a risk associated effect of comorbidities on general condition patient. The aim this article was an attempt to identify factors postoperative complications in treated NSCLC, special focus coexisting diseases.<br><b>METHODS:</b> A total 400 NSCLC were included retrospective study. incidence (including major according European...
Lung cancer is the most common in Poland and worldwide, leading cause of cancer-related deaths. Compared to present day, annual number new cases lung will have increased by approximately 50%, 2030. The overall ratio mortality incidence totals 0.87 among highest. five-year survival rate has recently achieved 13.4%. In 2015, screening using low-dose computed tomography (LDCT) was introduced routine clinical practice United States following publication largest randomised study, National...