A5003466534- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Occupational and environmental lung diseases
- Myasthenia Gravis and Thymoma
- Sarcoidosis and Beryllium Toxicity Research
- Cardiac tumors and thrombi
- Multiple and Secondary Primary Cancers
- Congenital Diaphragmatic Hernia Studies
- Pericarditis and Cardiac Tamponade
- Histiocytic Disorders and Treatments
- Neuroblastoma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Vasculitis and related conditions
Instytut Gruźlicy i Chorób Płuc
2010-2024
Foundation for Polish Science
2024
Masih Daneshvari Hospital
2005-2023
National Institute of Public Health
2004-2022
National Center for Tuberculosis and Lung Disease
2014-2021
Polskie Towarzystwo Gastroenterologii
2014
Holografika (Hungary)
2008
GATA3 is a transcription factor important in the differentiation of breast epithelia, urothelia, and subsets T lymphocytes. It has been suggested to be useful evaluation carcinomas mammary or urothelial origin metastatic carcinomas, but its distribution normal neoplastic tissues incompletely mapped. In this study, we examined developing adult 2040 epithelial 460 mesenchymal neuroectodermal neoplasms for expression explore diagnostic value surgical pathology, using monoclonal antibody (clone...
The analysis of plasma cell-free DNA (cfDNA) is expected to provide useful biomarkers for early diagnosis non-small-cell lung cancer (NSCLC). However, it remains unclear whether the intense release cfDNA into bloodstream NSCLC patients results from malignancy or chronic inflammatory response. Consequently, current diagnostic utility quantification has not been thoroughly validated in subjects with respiratory inflammation. Here we assess effect inflammation on levels and evaluate potential...
// Shingo Inaguma 1, 2 , Zengfeng Wang 1 Jerzy Lasota Masanori Onda 3 Piotr Czapiewski 4, 5 Renata Langfort 6 Janusz Rys 7 Joanna Szpor 8 Waloszczyk 9 Krzysztof Okoń Wojciech Biernat 4 Hiroshi Ikeda David S. Schrump 10 Raffit Hassan Ira Pastan Markku Miettinen Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA Department Aichi Medical University School Medicine, Nagakute, Japan Molecular Biology, Pathomorphology, Gdansk, Poland Otto-von-Guericke Magdeburg, Germany...
Diffuse malignant mesothelioma of the pleura (MPM) is a highly aggressive tumour that typically associated with short survival. CD70 and CD27 belong to necrosis factor (TNF) TNF receptor (TNFR) superfamily, respectively. Under physiological conditions, tightly regulated interaction between plays co-stimulatory role in promoting T-cell expansion differentiation through NFκB pathway. Aberrantly high expression has been documented haematological solid malignancies association immune evasion...
Losses in the succinate dehydrogenase (SDH) complex characterize 20% to 30% of extra-adrenal paragangliomas and 7% 8% gastric GISTs, rare renal cell carcinomas. This loss is reflected as lack normally ubiquitous immunohistochemical expression SDH subunit B (SDHB). In paragangliomas, SDHB correlates with homozygous any subunits, typically by loss-of-function mutations. The occurrence losses other epithelial malignancies unknown. this study, we immunohistochemically examined 2258 epithelial,...
Background Cryptogenic organizing pneumonia (COP) is a clinicopathological syndrome of unknown origin. Corticosteroids are the standard treatment, but clarithromycin (CAM) also effective. The aim this observational retrospective study was to compare results CAM versus prednisone (PRE) treatment in patients with biopsy-proven OP without respiratory insufficiency. Material and methods In 15-year period, 40 were treated (500 mg twice daily orally for 3 months) 22 PRE (mean initial dose 0.67 ±...
A 62-year-old, obese woman, smoking 10 pack/year was admitted to the National Tuberculosis and Lung Diseases Research Institute diagnose small, round opacities revealed by routine chest X-ray examination. These lesions had been observed for 5 years. The patient treated psoriasis, hypertension, insulin-independent diabetes. On admission she in good condition, complaining of a slight productive cough as well intermittent osteoarticular pain. Physical examination cutaneous psoriatic lesions,...
Introduction: This document presents the Guideliness of Polish Respiratory Society (PTChP, Polskie Towarzystwo Chorób Płuc) for diagnosis and treatment idiopathic pulmonary fibrosis (IPF), developed by agroup experts. Material methods: The recommendations were in form answers to previously formulated questions concer-ning everyday diagnostic therapeutic challenges. They based on acurrent literature review using Grading Recommendations Assessment, Development Evaluation (GRADE) methodology....
Fibrotic hypersensitivity pneumonitis (fHP) shares many features with other fibrotic interstitial lung diseases (ILD), and as a result it can be misdiagnosed idiopathic pulmonary fibrosis (IPF). We aimed to determine the value of bronchoalveolar lavage (BAL) total cell count (TCC) lymphocytosis in distinguishing fHP IPF evaluate best cut-off points discriminating these two ILD.A retrospective cohort study patients diagnosed between 2005 2018 was conducted. Logistic regression used diagnostic...
We report the case of a 20-year-old female with disseminated Mycobacterium avium disease involving bones, lungs and brain. She was completely healthy up until present illness had been vaccinated BCG in infancy without complications. Mycobacteriosis progressed spite treatment antituberculous drugs controlled only after addition interferon-gamma subcutaneously. A homozygous hypomorphic I87T mutation found gene encoding ligand-binding chain IFN-gamma receptor (IFNgammaR1). This is known...
The aim of the study was to assess prognostic value cytokeratin 19 fragments (Cyfra 21-1), carcinoembryonic antigen (CEA) and C-reactive protein (CRP) in surgically treated NSCLC patients.50 patients (25 adenocarcinoma, 21 squamous cell 4 adenosquamous), clinical stages I II, age 42-89 years, entered study. CEA, Cyfra 21-1 CRP concentrations were measured serum taken before surgery, CEA 50 patients, - 46 patients. survival calculated from date surgical treatment until death or end...
Molecular testing is recommended in patients with metastatic non-small cell lung cancer (NSCLC), but the extent of its use Poland unknown. The aim POL-MOL study was to investigate frequency using molecular Polish NSCLC. invited oncologists completed two questionnaires, and data for 1001 undergoing systemic treatment NSCLC were collected. tests following genetic mutations recorded:
MicroRNAs (miRNAs), key regulators of gene expression at the post-transcriptional level, are grossly misregulated in some human cancers, including non-small-cell lung carcinoma (NSCLC). The aberrant specific miRNAs results abnormal regulation components signalling pathways tumour cells. MiRNA levels and activity targets, oncogenes suppressors, produce feedback that changes miRNA indicates cell's genetic activity. In this study, we measured five circulating (miR-195, miR-504, miR-122, miR-10b...
This study was an epidemiological analysis of all primary mediastinal neoplasms (PMNs) diagnosed between 2000 and 2016 at the National Tuberculosis Lung Diseases Research Institute, Poland.
Video-assisted thoracic surgery (VATS) is increasingly used in the surgical treatment of early lung cancer, but oncological benefits are still controversial. We aimed to compare video-assisted lobectomy and open thoracotomy terms lymphadenectomy long-term survival depending on location lobectomy.A retrospective, multicenter study was based Polish Lung Cancer Study Group included patients with stage I cancer who were surgically treated between 2007 2015. 1410 after 4,855 thoracotomy.The...
Abstract Diffuse pleural mesothelioma (PM) is a highly aggressive tumour typically associated with short survival. Recently, the effectiveness of first‐line immune checkpoint inhibitors in patients unresectable PM was reported. CD70–CD27 signalling plays co‐stimulatory role promoting T cell expansion and differentiation through nuclear factor κB (NF‐κB) pathway. Conversely, PD‐L1 (CD274)–PD‐1 (PDCD1) pathway crucial for modulation responses normal conditions. Nevertheless, pathological...