A5003570656- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gastrointestinal motility and disorders
- Sarcoidosis and Beryllium Toxicity Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Neonatal Respiratory Health Research
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Tracheal and airway disorders
- Gastric Cancer Management and Outcomes
- Vascular Anomalies and Treatments
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Ultrasound in Clinical Applications
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Occupational and environmental lung diseases
- Whipple's Disease and Interleukins
- Inflammasome and immune disorders
- Microbial Community Ecology and Physiology
Medical University of Lodz
2016-2025
Brno University of Technology
2024
Centre Hospitalier Universitaire de Lille
2021
Université de Lille
2021
Houston Advanced Research Center
2015-2017
ENT and Allergy
2015-2017
Instytut Gruźlicy i Chorób Płuc
2017
Wojewódzki Szpital Specjalistyczny Nr 2
2016
Essen University Hospital
2004-2015
Klinik und Poliklinik für Urologie
2015
Essential oils obtained from the NR (normal roots) and HR (hairy of medicinal plant Leonurus sibiricus root were used in this study. The essential oil compositions detected by GC‐MS. Eighty‐five components identified total. Seventy for oil. major constituents β ‐selinene (9.9%), selina‐4,7‐diene (9.7%), (E) ‐ ‐caryophyllene (7.3%),myli‐4(15)‐ene (6.4%), guaia‐1(10),11‐diene (5.9%). Sixty‐seven oil, main being (22.6%), germacrene D (19.8%). tested cytotoxic effect, antimicrobial,...
Summary Background : This study aimed to assess the efficacy of artichoke leaf extract (ALE) in treatment patients with functional dyspepsia (FD). Methods In a double‐blind, randomized controlled trial (RCT), 247 were recruited and treated either commercial ALE preparation (2 × 320 mg plant t.d.s.) or placebo. The primary variable was sum score patient's weekly rating overall change dyspeptic symptoms (four‐point scale). Secondary variables scores each symptom quality life (QOL) as assessed...
Summary Aim: To validate the gastrointestinal symptom score as an outcome measure for functional dyspepsia. Methods: In focus groups, 10 dyspepsia‐specific items including nausea, sickness, vomiting, bloating, abdominal cramps, early satiety, acidic eructation/heartburn, loss of appetite, retrosternal discomfort, epigastric pain/upper pain were identified. Ninety‐five patients with dyspepsia and 56 healthy controls recruited responsiveness evaluated by analysing data from 357 previous...
The role of mitochondria in post coronavirus disease 2019 (post-COVID-19) complications is unclear, especially the long-term pulmonary complications. This study aims to investigate association between post-COVID-19 and mitochondrial regulatory proteins context oxidative stress.Patients who had recovered from COVID-19 were enrolled. According evidence persistent interstitial lung lesions on computed tomography (CT), patients divided into a group (P(+)) control without (P(-)). We randomly...
This study evaluates the usefulness of serum KL-6, SP-D and TGF-β1 levels in assessing lung impairment predicting interstitial disease (ILD) short-term progression patients with pneumonia autoimmune features (IPAF). A total 24 IPAF, 21 connective tissue disease-associated ILD (CTD-ILD) 23 CTD without were followed for 1 year. Serum measured their associations severity analysed. significantly higher IPAF CTD-ILD compared to (p < 0.0001, p = 0.0005 respectively). KL-6 (r 0.45, 0.002) 0.35,...
Sprague-Dawley rats were treated for 14 days with rapamycin (RAP; 1.5 mg/kg/day i.p.), cyclosporine (15 by gavage), both drugs in combination, or appropriate drug vehicles. Hematological parameters and biochemical indices of renal hepatic function determined throughout the experimental period, at end which killed tissues examined histologically. There was a significant reduction weight gain RAP- but not CsA-treated animals, while given showed body over 14-day period. no alterations absolute...
(1) Introduction: The role of soluble integrins in post-COVID-19 complications is unclear, especially long-term pulmonary lesions. purpose this study was to investigate the association between ITGa2, ITGaM and ITGb2 integrin subunits long COVID-19 complications. (2) Methodology: Post-COVID-19 patients were enrolled. According evidence persistent interstitial lung lesions on CT, divided into a group (P(+)) control without (P(-)). We randomly selected 80 for further investigation (40 subjects...
Idiopathic pulmonary fibrosis (IPF) is a progressive and inevitably fatal disease with heterogeneous clinical course. This study aimed to evaluate the usefulness of circulating biomarkers in routine IPF practice. We conducted an exploratory cohort 28 subjects qualified for anti-fibrotic therapy up 24 months serial measurements seven biomarkers, including those that are well-established, Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), matrix metalloproteinase 7 (MMP-7), more...
Background Although chitin is absent in humans, chitinases are present healthy subjects and show dysregulated expression a variety of diseases resulting from abnormal tissue injury repair responses. It was shown that chitotriosidase (chitinase 1/CHIT1) structurally-related chitinase 3-like 1 protein (CHI3L1/YKL-40) play important roles the pathobiology idiopathic pulmonary fibrosis (IPF), however little known about their longitudinal serum levels relationship to clinical measures IPF....
Introduction: This document presents the Guideliness of Polish Respiratory Society (PTChP, Polskie Towarzystwo Chorób Płuc) for diagnosis and treatment idiopathic pulmonary fibrosis (IPF), developed by agroup experts. Material methods: The recommendations were in form answers to previously formulated questions concer-ning everyday diagnostic therapeutic challenges. They based on acurrent literature review using Grading Recommendations Assessment, Development Evaluation (GRADE) methodology....
Exacerbations of COPD (ECOPD) are important events in the course and they accelerate rate decline lung function, exacerbations requiring hospitalization associated with significant mortality. Therefore, developing approaches prevention early treatment ECOPDs special clinical interests. One such is telecare, including home telemonitoring.Daily telemonitoring HR, BP, SpO2 spirometry was performed. Variables were compared using bootstrap-boosted inference tests: paired t-test or Wilcoxon signed...
Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPDs) are one the most important clinical aspects disease, and when requiring hospital admission, they significantly contribute to mortality among COPD patients. Our aim was assess role eosinopenia neutrophil-to-lymphocyte count (NLR) as markers in-hospital length hospitalization (LoH) patients with ECOPD hospitalization. We included 275 Eosinopenia associated deaths only coexisted lymphocytopenia, specificity 84.4% (95% CI...
Abstract Objective: Visceral hyperalgesia (VH) plays a key role for the manifestation of functional gastrointestinal (GI) disorders. In subgroup patients, initial is preceded by GI inflammation. Recent studies have demonstrated an improvement inflammation and symptoms during treatment with Escherichia coli Nissle 1917 ( EcN ). Aim: We aimed to characterize effects on visceral sensitivity in rat model post‐inflammatory VH. Methods: Male Lewis rats underwent colorectal instillation...
Background: Platelets may actively participate in inflammation COPD. Platelet distribution width (PDW), a measure of platelets' volume heterogeneity, increase activation. We hypothesized that PDW be marker hypercoagulation, which plays significant role conditions associated with worse survival patients COPD, eg, acute myocardial infarction and other forms ischemic heart disease. Methods: Retrospective analysis 79 patients. Variables were compared after grouping according to the upper normal...