A5040838450- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Microscopic Colitis
- Eosinophilic Esophagitis
- Pain Mechanisms and Treatments
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Acupuncture Treatment Research Studies
- Therapeutic Uses of Natural Elements
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Digestive system and related health
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Neuropeptides and Animal Physiology
- Celiac Disease Research and Management
- Liver Disease and Transplantation
- Intestinal and Peritoneal Adhesions
- Infant Health and Development
- Antiplatelet Therapy and Cardiovascular Diseases
- Abdominal vascular conditions and treatments
- Tracheal and airway disorders
- Blood transfusion and management
- Organ Transplantation Techniques and Outcomes
Deutsche Schmerzgesellschaft
2022
Israelitisches Krankenhaus
2022
Universitätsklinikum Erlangen
2015-2021
Bayer (Germany)
2017
University Hospital of Bern
2005-2016
University of Bern
2005-2016
Friedrich-Alexander-Universität Erlangen-Nürnberg
2015
United States Congress
2007
Robarts Clinical Trials
2007
University of Rijeka
2007
Background Eosinophilic oesophagitis (EO) is a chronic inflammatory disorder of the oesophagus that rapidly increasing in prevalence. Although systemic and topical corticosteroids are effective treating EO, some patients develop corticosteroid dependency. Alternative therapeutic approaches avoid scarce. Aim To analyse our experience at inducing maintaining remission with an immunomodulatory therapy steroid-dependent EO patients. Methods We analysed clinical histological response to...
Transient inflammation is known to alter visceral sensory function and frequently precede the onset of symptoms in a subgroup patients with irritable bowel syndrome (IBS). Duration severity initial inflammatory stimulus appear be risk factors for manifestation symptoms. Therefore, we aimed characterize dose-dependent effects trinitrobenzenesulfonic acid (TNBS)/ethanol on: (1) colonic mucosa, (2) cytokine release (3) rat model. Acute was induced male Lewis rats by single administration...
Strictures are a frequent complication of eosinophilic esophagitis. The efficacy and safety topical corticosteroids dilation esophagitis-associated strictures have not yet been thoroughly clarified. We present retrospective analysis 10 adult patients with esophagitis who had symptomatic esophageal stenosis that was unresponsive to corticosteroids, were treated using bougienage. Eight one single stricture, patient two, another three strictures; mean stricture length 2.1 cm (range 1 - 6 cm)....
SUMMARY Aim : To compare the efficacy of simethicone with placebo and prokinetic cisapride in patients functional dyspepsia. Methods One hundred eighty‐five dyspepsia were randomized treated a double‐dummy technique (105 mg t.d.s.), (10 t.d.s.) or (t.d.s.). The primary outcome measure was O'Brien global patients' rating 10 upper gastrointestinal symptoms (graded as absent=0, moderate=1, severe=2 very severe=3). Outcome measures assessed at baseline after 2, 4 8 weeks treatment...
Background and study aims: The reference surveillance method in patients with Barrett's esophagus is careful endoscopic observation, targeted as well random four-quadrant biopsies. Autofluorescence endoscopy (AFE) may make it easier to locate neoplasia. aim of this was elucidate the diagnostic accuracy AFE-guided plus biopsies comparison conventional approach. Patients methods: A total 187 200 consecutive who were initially enrolled (73 % male, mean age 67 years, segment length 4.6 cm),...
Patients with esophageal cancer and a malignant tracheoesophageal fistula (TEF) have an extremely poor prognosis. Additionally, these patients often are denied treatment radiation therapy because there is concern that treatments may increase the size associated problems of TEF.To determine appropriate (use therapy) for TEF, review was performed all such cases seen at Mayo Clinic between 1971 1991.Between 1991, 41 TEF arising as result were in Rochester. Twenty-eight cancers locally...
This study aimed to characterize the role of neuropeptide calcitonin gene‐related peptide (CGRP) in development mechanically induced visceral hyperalgesia. Tonic colorectal distension (CRD) was performed fasted, conscious male Sprague–Dawley rats. The visceromotor reflex associated with noxious CRD determined as number contractions during each two consecutive tonic distensions (10 min at 60 mmHg), which were separated by a series phasic (repeated 15‐s 80 mmHg 30‐s intervals). effect CGRP...
Abstract In a number of different experimental paradigms somatic pain, there is evidence for vagally mediated antinociceptive system. This pathway probably involves opioid mechanisms. However, whether this activated in visceral pain or if it subdiaphragmatic vagal afferents unclear. The aim the present study was to determine mediate antinociception response stimulus and an pathway. Colorectal distension performed fasted, conscious male Sprague–Dawley rats using balloon catheter connected...
Schlüsselwörter Reizdarm - Intestinale Motilität Obstipation Diarrhoe
To assess magnetic resonance (MR)-colonography (MRC) for detection of colorectal lesions using two different T1w three-dimensional (3D)-gradient-recalled echo (GRE)-sequences and integrated parallel data acquisition (iPAT) at a 3.0 Tesla MR-unit.In this prospective study, 34 symptomatic patients underwent dark lumen MRC unit before conventional colonoscopy (CC). After colon distension with tap water, 2 high-resolution 3D-GRE [3-dimensional fast low angle shot (3D-FLASH), iPAT factor...
Die vorliegenden Empfehlungen für Indikationen, Durchführung und Interpretation der ösophagealen Refluxdiagnostik stellen eine Aktualisierung zur 24 h-pH-Metrie beim Erwachsenen von 2003 dar unter Berücksichtigung aktuellen Publikationen sowie neuen Techniken (kabellose) pH-Messung, Impedanz-Messung Bilirubin-Messung (Bestimmung eines duodenogastroösophagealen Refluxes).
Misuse of various new psychotropic substances such as ibogaine is increasing rapidly. Knowledge their negative side effects sparse. We present a case intoxication with the herbal substance in 22-year-old white man. After taking cumulative dose 38 g (taken two doses), he developed visual memories, nausea and vomiting. He generalized tonic–clonic seizure additional grand mal seizures. was treated midazolam levetiracetam. Extended drug screenings computed tomography magnetic resonance imaging...
Most patients with functional bowel disorders complain of daytime symptoms while they remain asymptomatic at night. As are associated heightened visceral sensitivity, we hypothesized that circadian fluctuations the sensory function occur. At four different timepoints (06.00, 12.00, 18.00 and 24.00 h), colorectal distensions (CRD) were performed in fasting conscious male Lewis rats using a balloon catheter barostat device. The abdominal wall contractions (behavioural pain response) assessed...
Functional gastrointestinal disorders affect females more often. Changes in colonic motility may be etiological co-factors for the clinical symptoms. The aim of present study was to analyze influence gonadal hormones on contractile activity.In vitro measurements activity longitudinal smooth muscle strips female and male Lewis rats were performed an organ chamber experiment. After administration a hormone estradiol [EST], progesterone [PROG] testosterone [TEST]) or ethanol solution as...
Abstract Background The high prevalence of functional bowel disorders among the general population contrasts with limited number pharmacological treatment options for this condition. This has led to an interest alternative therapeutic approaches. Padma® Lax is herbal laxative on basis Tibetan formulas. Our aim examine effect Padma (A) visceral nociception in vivo and (B) contractile activity longitudinal smooth muscle lower gut vitro ex . Methods Visceral sensory function response colorectal...
Abstract Background Increased prevalence of functional gastrointestinal disorders in women and perimenstrually accentuated symptoms imply that sexual hormones play a crucial role the pathogenesis such syndromes. The aim this study was to analyze selective effect estrogen on visceral sensitivity gonadectomized female male Lewis rats with or without prior treatment butyrate enemas. Methods Following ovariectomy ( OVX ) orchiectomy ORX estradiol pellets (E2‐P) sham (Sham‐P) were implanted....