A5045991816- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Diet and metabolism studies
- Digestive system and related health
- Congenital gastrointestinal and neural anomalies
- Esophageal Cancer Research and Treatment
- Infant Health and Development
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- Respiratory and Cough-Related Research
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Tracheal and airway disorders
- Intestinal Malrotation and Obstruction Disorders
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Pelvic floor disorders treatments
- Intestinal and Peritoneal Adhesions
- Gut microbiota and health
- Analytic and geometric function theory
University Hospital of Zurich
2015-2024
University of Zurich
2007-2024
Columbia University Irving Medical Center
2023
Swiss HIV Cohort Study
2023
Deutsche Schmerzgesellschaft
2022
Israelitisches Krankenhaus
2022
University Hospital of North Norway
2022
University of Würzburg
1975-2020
Fischer (Germany)
2016-2018
Süleyman Demirel University
2011-2018
Lactose malabsorption is a common condition caused by reduced expression or activity of lactase in the small intestine. In such patients, lactose intolerance characterized abdominal symptoms (e.g. nausea, bloating, and pain) after ingestion dairy products. The genetic basis established several tests for this are available, including genetic, endoscopic, H2-breath tests. contrast, less well understood. Recent studies show that risk depends on dose lactose, expression, intestinal flora,...
Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite its prevalence, FD associated with major uncertainties terms definition, underlying pathophysiology, diagnosis, treatment, and prognosis.A Delphi consensus was initiated 41 experts from 22 European countries who conducted a literature summary voting process on 87 statements. Quality evidence evaluated using grading recommendations, assessment, development, evaluation (GRADE) criteria. Consensus...
Objective Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients gastroparesis. Design In this prospective randomised trial, we compared G-POEM sham procedure severe The primary was the proportion of success (defined as decrease Gastroparesis Cardinal Symptom Index (GCSI) by at least 50%) 6 months. Patients to group persistent symptoms were offered cross-over G-POEM. Results enrolment stopped after interim analysis...
INTRODUCTION Nonerosive reflux disease (NERD) is the most common form of gastroesophageal disease. While role acid has been established, relevance nonacid in generating symptoms NERD unknown. AIM To evaluate diagnostic utility impedance-pH monitoring patients. METHODS Patients with typical (heartburn and/or regurgitation) and normal endoscopy underwent a combined off proton pump inhibitor (PPI) therapy. Previously investigated 48 healthy volunteers served as controls. Distal esophageal...
<h3>Introduction:</h3> Functional dyspepsia and non-erosive reflux disease (NERD) are prevalent gastrointestinal conditions with accumulating evidence regarding an overlap between the two. Still, patients NERD represent a very heterogeneous group limited data on dyspeptic symptoms in various subgroups of available. <h3>Aim:</h3> To evaluate prevalence subclassified by using 24 h impedance-pH monitoring (MII-pH). <h3>Methods:</h3> Patients typical normal endoscopy underwent off proton pump...
We sought to compare reflux and symptom association patterns in patients with nonerosive disease (NERD), erosive esophagitis (EE), healthy volunteers (HVs).Patients EE NERD underwent combined impedance-pH monitoring. Normal values were defined on the basis of previously collected data from 48 HVs. evaluated distal esophageal acid exposure time (AET), number type episodes (acid, nonacid), bolus clearance times, proximal extension episodes, probability (SAP).Distal AET (percentage time, pH<4)...
Limited data are available regarding the frequency of oesophageal motility and bolus transit abnormalities in subgroups patients with gastro-oesophageal reflux disease (GERD).To assess endoscopically defined GERD subgroups.Patients (N=755) typical symptoms underwent upper endoscopy, conventional or impedance manometry and/or impedance-pH testing. They were divided into: erosive oesophagitis (EO; N=340), Barrett Oesophagus (BO; N=106), non-erosive (NERD; endoscopy-, abnormal pH SAP/SI+;...
Abstract Background Butyrate has shown anti‐inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic‐delivery formulation butyrate on fecal microbiota with inflammatory bowel diseases (IBDs). Methods In this double‐blind, placebo‐controlled, pilot study, 49 IBD (n = 19 Crohn's disease, CD n 30 ulcerative colitis, UC) were randomized to oral administration...
Main Recommendations ESGE suggests flexible endoscopic treatment over open surgical as first-line therapy for patients with a symptomatic Zenker’s diverticulum of any size. Weak recommendation, low quality evidence, level agreement 100 %. recommends that emerging treatments diverticulum, such peroral myotomy (Z-POEM) and tunneling, be considered experimental; these should offered in research setting only. Strong against the widespread clinical use transoral incisionless fundoplication (TIF)...
Main Recommendations ESGE recommends the use of a graded pneumatic dilation protocol in achalasia, starting with 30-mm and followed by 35-mm at planned interval 2 – 4 weeks, subsequent 40-mm when there is insufficient relief, over both single balloon procedure or larger from outset. Strong recommendation, high quality evidence, level agreement 100 %. being cautious treating spastic motility disorders other than achalasia peroral endoscopic myotomy (POEM). very low 87.5 against routine...
The goal of this project was to create an up-to-date joint European clinical practice guideline for the diagnosis and treatment faecal incontinence (FI), using best available evidence. These guidelines are intended help guide all medical professionals treating adult patients with FI (e.g., general practitioners, surgeons, gastroenterologists, other healthcare workers) any who interested in information regarding management FI.These have been created cooperation members from United...
We describe the spectrum of findings and diagnostic value MR defecography in patients referred with suspicion dyssynergic defecation.48 (34 females, 14 males; mean age 48 years) constipation clinically suspected defecation underwent defecography. Patients were divided into (n = 18) constipated without (control group, n 30). MRIs analysed for evacuation ability, time to initiate evacuation, changes anorectal angle (ARA-change), presence paradoxical sphincter contraction additional pelvic...
Abstract Background Many patients complain of abdominal symptoms with dairy products; however, clinical and psychosocial factors associated self‐reported lactose intolerance ( SLI ) have not been assessed in large studies. In particular, data are lacking from lactase deficient populations. This prospective cohort study the prevalence of, risk for, Chinese attending a gastroenterology clinic. Methods Consecutive completed questionnaires to assess digestive health (Rome III), psychological...
Abkürzungsverzeichnis ACPO: akute colonische Pseudoobstruktion, syn. Ogilvie-Syndrom CED: chronisch entzündliche Darmerkrankungen CI: Confidence Interval, engl. CIPO: chronische intestinale Pseudoobstruktion CMV: Cytomegalie-Virus ENS: enterisches Nervensystem FBDSI: Functional Bowel Disorder Severity Index FBS: Funktionelle Bauchschmerzen (engl. FAB, functional abdominal pain) FD: Dyspepsie GSRS-IBS: Gastrointestinal Symptom Rating Score HADS: Hospital Anxiety Depression Scale, H&E:...
Abstract Esophageal hypomotility disorders manifest with abnormal esophageal body contraction vigor, breaks in peristaltic integrity, or failure of peristalsis the context normal lower sphincter relaxation on high‐resolution manometry (HRM). The Chicago Classification version 4.0 recognizes two disorders, ineffective motility (IEM) and absent contractility, while fragmented has been incorporated into IEM definition. Updated criteria for swallows consist weak vigor measured using distal...