Agata Mulak

ORCID: 0000-0003-4678-8393
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About
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Research Areas
  • Gastrointestinal motility and disorders
  • Helicobacter pylori-related gastroenterology studies
  • Diet and metabolism studies
  • Gut microbiota and health
  • Gastroesophageal reflux and treatments
  • Microscopic Colitis
  • Fibroblast Growth Factor Research
  • Pancreatitis Pathology and Treatment
  • Congenital gastrointestinal and neural anomalies
  • Infant Health and Development
  • Digestive system and related health
  • Inflammatory Bowel Disease
  • Mindfulness and Compassion Interventions
  • Child Nutrition and Feeding Issues
  • Eosinophilic Esophagitis
  • Clostridium difficile and Clostridium perfringens research
  • Pelvic floor disorders treatments
  • Parathyroid Disorders and Treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Complementary and Alternative Medicine Studies
  • Pain Mechanisms and Treatments
  • Music Therapy and Health
  • Stress Responses and Cortisol
  • Cancer, Stress, Anesthesia, and Immune Response
  • Celiac Disease Research and Management

Wroclaw Medical University
2016-2025

University of California, Los Angeles
2011-2024

VA Greater Los Angeles Healthcare System
2010-2024

Medical University of Sofia
2020

Inserm
2015

October 6 University
2015

Centre Hospitalier Universitaire de Grenoble
2015

University of Washington
2012

STZ eyetrial
2012

Center for Digestive and Liver Diseases
2011

Background & AimsAlthough functional gastrointestinal disorders (FGIDs), now called of gut-brain interaction, have major economic effects on health care systems and adversely affect quality life, little is known about their global prevalence distribution. We investigated the factors associated with 22 FGIDs, in 33 countries 6 continents.MethodsData were collected via Internet 24 countries, personal interviews 7 both 2 using Rome IV diagnostic questionnaire, III irritable bowel syndrome...

10.1053/j.gastro.2020.04.014 article EN cc-by-nc-nd Gastroenterology 2020-04-12

Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite its prevalence, FD associated with major uncertainties terms definition, underlying pathophysiology, diagnosis, treatment, and prognosis.A Delphi consensus was initiated 41 experts from 22 European countries who conducted a literature summary voting process on 87 statements. Quality evidence evaluated using grading recommendations, assessment, development, evaluation (GRADE) criteria. Consensus...

10.1002/ueg2.12061 article EN cc-by-nc-nd United European Gastroenterology Journal 2021-04-01

AIM:To evaluate the utility of serum and urine metabolomic analysis in diagnosing monitoring inflammatory bowel diseases (IBD). METHODS:Serum samples were collected from 24 patients with ulcerative colitis (UC), 19 Crohn's disease (CD) 17 healthy controls.The activity UC was assessed Simple Clinical Colitis Activity Index, while CD determined using Harvey-Bradshaw Index.The performed proton nuclear magnetic resonance (NMR) spectroscopy.All spectra exported to Matlab for preprocessing which...

10.3748/wjg.v20.i1.163 article EN cc-by-nc World Journal of Gastroenterology 2014-01-01

Abstract Background Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The challenging clinical practice lack guidance concerning diagnosis management gastroparesis. Methods A Delphi consensus was undertaken 40 experts from 19 European countries who conducted literature summary voting process on 89 statements. Quality evidence evaluated using grading recommendations assessment, development,...

10.1002/ueg2.12060 article EN cc-by-nc-nd United European Gastroenterology Journal 2021-04-01

Alpha-synucleinopathy constituting a characteristic feature of Parkinson's disease (PD) occurs at all levels the brain-gut axis including enteric nervous system (ENS). Lesions in ENS may be connected with gut inflammation, increased intestinal permeability and dysmotility contributing to pathogenesis PD its gastrointestinal manifestations. To evaluate fecal calprotectin zonulin as biomarkers inflammation barrier dysfunction patients. Quantitative evaluation was performed by ELISA tests 35...

10.3389/fnins.2019.00992 article EN cc-by Frontiers in Neuroscience 2019-09-27

Stressors of different psychological, physical or immune origin play a critical role in the pathophysiology irritable bowel syndrome participating symptoms onset, clinical presentation as well treatment outcome.Experimental stress models applying variety acute and chronic exteroceptive interoceptive stressors have been developed to target periods throughout lifespan animals assess vulnerability, trigger perpetuating factors determining influence on visceral sensitivity interactions within...

10.5056/jnm.2011.17.3.213 article EN cc-by-nc Journal of Neurogastroenterology and Motility 2011-07-31

Gastroparesis is a condition characterized by epigastric symptoms and delayed gastric emptying (GE) rate in the absence of any mechanical obstruction. The challenging clinical practice lack guidance concerning diagnosis management gastroparesis.A Delphi consensus was undertaken 40 experts from 19 European countries who conducted literature summary voting process on 89 statements. Quality evidence evaluated using grading recommendations assessment, development, evaluation criteria. Consensus...

10.1111/nmo.14237 article EN Neurogastroenterology & Motility 2021-08-01

Abstract Background and Aims The Rome Foundation Global Epidemiology Study (RFGES) assessed the prevalence, burden, associated factors of Disorders Gut–Brain Interaction (DGBI) in 33 countries around world. Achieving worldwide sampling necessitated use two different surveying methods: In‐person household interviews (9 countries) Internet surveys (26 countries). Two countries, China Turkey, were surveyed with both methods. This paper examines differences survey results methods, as well likely...

10.1111/nmo.14583 article EN cc-by-nc-nd Neurogastroenterology & Motility 2023-04-05

Functional dyspepsia (FD) is one of the most common conditions in clinical practice. In spite its prevalence, FD associated with major uncertainties terms definition, underlying pathophysiology, diagnosis, treatment, and prognosis.A Delphi consensus was initiated 41 experts from 22 European countries who conducted a literature summary voting process on 87 statements. Quality evidence evaluated using grading recommendations, assessment, development, evaluation (GRADE) criteria. Consensus...

10.1111/nmo.14238 article EN Neurogastroenterology & Motility 2021-09-01

Disorders of gut-brain interaction (DGBI) are characterized by debilitating symptoms not explained structural or biochemical abnormalities. While functional conditions present with complex, likely heterogeneous pathophysiology, we aimed to investigate if proxy measures sociocultural and environmental factors associated the prevalence various DGBI in populations across world.

10.1111/nmo.14866 article EN cc-by-nc Neurogastroenterology & Motility 2024-07-15

ABSTRACT Introduction Chronic nausea and vomiting are symptoms of a wide range gastrointestinal non‐gastrointestinal conditions. Diagnosis can be challenging requires systematic well‐structured approach. If the initial investigation for structural, toxic metabolic disorders is negative, digestive motility gut‐brain interaction should assessed. United European Gastroenterology (UEG) Society Neurogastroenterology Motility (ESNM) identified need an updated, evidence‐based clinical guideline...

10.1002/ueg2.12711 article EN cc-by-nc-nd United European Gastroenterology Journal 2025-01-04

Abstract Background Chronic psychological stress‐induced alterations in visceral sensitivity have been predominantly assessed male rodents. We investigated the effect of acute and repeated water avoidance stress (WAS) on visceromotor response (VMR) to colorectal distension (CRD) role opioids cycling female Wistar rats using a novel non‐invasive manometric technique. Methods After baseline VMR (1st CRD, day 0), were exposed WAS (1 h −1 ) either once or for four consecutive days, without...

10.1111/j.1365-2982.2012.01980.x article EN Neurogastroenterology & Motility 2012-07-09

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Pietrzak A, Skrzydło-Radomańska B, Mulak et al. Guidelines on the management of irritable bowel syndrome. Gastroenterology Review/Przegląd Gastroenterologiczny. 2018;13(4):259-288. doi:10.5114/pg.2018.78343. APA Pietrzak, A., Skrzydło-Radomańska, B., Mulak, Lipiński, M., Małecka-Panas, E., & Reguła, J. (2018). Gastroenterologiczny, 13(4), 259-288. https://doi.org/10.5114/pg.2018.78343 Chicago Anna, Barbara...

10.5114/pg.2018.78343 article EN Gastroenterology Review 2018-01-01

Pancreatolithiasis occurs in less than 1% of the general population and is mainly recognized patients with chronic pancreatitis. Selection appropriate treatment method depends on location, size number stones.The aim study was to analyze data concerning pancreatic duct stones who were hospitalized at Wroclaw Medical University's Department Gastroenterology Hepatology from 2010 2014.The presents 16 stones, constituted 7% all 228 pancreatitis period. The clinical compared findings reported...

10.17219/acem/62687 article EN cc-by-nc-nd Advances in Clinical and Experimental Medicine 2017-06-27
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