A5026626368- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Vasculitis and related conditions
- Central Venous Catheters and Hemodialysis
- Neurological Complications and Syndromes
- Organ Donation and Transplantation
- Immune Response and Inflammation
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- COVID-19 Clinical Research Studies
- Organ and Tissue Transplantation Research
- Vascular Procedures and Complications
- Complement system in diseases
- Bipolar Disorder and Treatment
- Management Systems and Quality Improvement
- Dialysis and Renal Disease Management
- Pregnancy and Medication Impact
- Diabetes and associated disorders
- European Politics and Security
- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Wroclaw Medical University
2016-2025
University of Wrocław
2014-2024
National Institute of Standards and Technology
2023
Université de Lorraine
2023
University of Lower Silesia
2016
Polish Mother’s Memorial Hospital Research Institute
1998-2015
Memorial Hospital of South Bend
2001
AIM:To evaluate the utility of serum and urine metabolomic analysis in diagnosing monitoring inflammatory bowel diseases (IBD). METHODS:Serum samples were collected from 24 patients with ulcerative colitis (UC), 19 Crohn's disease (CD) 17 healthy controls.The activity UC was assessed Simple Clinical Colitis Activity Index, while CD determined using Harvey-Bradshaw Index.The performed proton nuclear magnetic resonance (NMR) spectroscopy.All spectra exported to Matlab for preprocessing which...
SUMMARY Blood samples were collected over a 4-year period from 335 children (aged 1–16 years) suffering recurrent respiratory infections and 78 controls. The patients subdivided into four groups: I, with no immune system defects detected (n = 101); II, allergies 94); III, humoral response 93); IV, disturbances of cellular immunity 66). Nineteen had both abnormalities. All controls investigated to determine the exon 1 promoter region variants mbl-2 gene. MBL serum concentrations also...
Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark CKD progression renal fibrosis characterized by excessive accumulation extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation urinary proteome classifier CKD273 individual peptides with degree fibrosis. total, 42 biopsies urine samples were examined. The percentage per total tissue area was assessed in Masson trichrome stained tissues. analysed capillary...
Abstract Background Risk of kidney function decline in immunoglobulin A (IgA) nephropathy (IgAN) is significant and may not be predicted by available clinical histological tools. To serve this unmet need, we aimed at developing a urinary biomarker-based algorithm that predicts rapid disease progression IgAN, thus enabling personalized risk stratification. Methods In multicentre study, urine samples were collected 209 patients with biopsy-proven IgAN. Progression was defined tertiles the...
Non-HLA antibodies (Abs) targeting vascular receptors are considered to have an influence on renal transplant injury. Anti-endothelin-1 type A receptor (anti-ETAR) were associated with cellular and antibody-mediated rejection early onset of vasculopathy in heart patients but their role transplantation remains unclear. The aim our study was assess the incidence importance anti-ETAR impact during first year observation.We evaluated presence 116 consecutive recipients pre- post-transplant...
The SARS-CoV-2 pandemic is a worldwide challenge. CRIT-CoV-U pilot study generated urinary proteomic biomarker consisting of 50 peptides (COV50), which predicted death and disease progression from SARS-CoV-2. After the interim analysis presented for German Government, here, we aimed to analyse full dataset consolidate findings propose potential clinical applications this biomarker.CRIT-CoV-U was prospective multicentre cohort study. In eight European countries (Austria, France, Germany,...
SUMMARY The lectin pathway of complement activation is used by a collectin, mannan-binding (MBL), and two ficolins, L-ficolin H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency associated with recurrent respiratory infections in childhood. have now measured serum 313 infection patients 74 healthy control children. concentrations below the lower limit group were found 6% (P < 0·02) most strongly children having co-existing...
Renal transplantation (RT) is the optimal renal replacement treatment approach in terms of patient survival and high quality life. Proper adherence to medication essential order prolong graft life survival. This study aimed investigate effects psychosocial factors age-related declines on kidney transplant recipients. Methods: was a cross-sectional recipients, based regression analysis. Patient assessed with Basel Assessment Adherence Immunosuppressive Medication Scale (BAASIS). Psychosocial...
Kidney transplantation (KT) is the best method for kidney replacement therapy (KRT) because of patient survival rates and quality life (QoL). Nowadays, main cause graft loss antibody-mediated rejection. The treatment humoral injury difficult with uncertain results still not firmly established. Therefore, appropriate adherence crucial to prolong survival. This study aims evaluate association transplant patients' acceptance illness, symptoms anxiety depression, frailty, QoL medication in KT...
Background. Obesity, which is often associated with diabetes, increasingly encountered in the haemodialysed population, and this may produce difficulty autogenous arteriovenous fistula creation. Prosthetic angioaccess or catheters, when used place of fistulas, increase thrombotic infectious complications these already challenged patients. Methods. This prospective study was undertaken to assess feasibility creation 71 obese patients (BMI 34.6 ± 7.8). We performed a two-stage procedure,...
Abstract Systemic metabolic changes after renal transplantation reflect the key processes that are related to graft accommodation. In order describe and better understand these changes, 1 HNMR based metabolomics approach was used. The of 47 metabolites in serum samples 19 individuals were interpreted over time with respect their levels prior transplantation. Considering specific repeated measures design experiments, data analysis mainly focused on multiple analyses variance (ANOVA) methods...
Background: Angiotensin-converting enzyme (ACE) is responsible for the production of angiotensin II, and increased II observed in diabetes. What more, ACE polymorphisms may play a role development diabetic nephropathy. The aim this study was to assess selected (rs4343 rs4646994) risk nephropathy likelihood renal replacement therapy. Methods: were analyzed group 225 patients who divided into three subgroups. rs4343 polymorphism determined using PCR-RFLP, rs4646994 PCR. Molecular docking...
Nitric oxide synthase (NOS) is an enzyme that catalyzes the formation of nitric (NO), altered production which characteristic diabetic nephropathy. NOS exists in three isoforms: NOS1, NOS2, and NOS3. Moreover, there are reports about potential role NOS3 polymorphisms development diabetes complications. The aim this study was to assess selected polymorphisms-rs3782218 (NOS1), rs1137933 (NOS2), rs1799983, rs2070744, rs61722009 (NOS3)-in risk developing nephropathy likelihood renal replacement...
Background/Objectives: Survival prospects following SARS-CoV-2 infection may extend beyond the acute phase, influenced by various factors including age, health conditions, and se-verity. However, this topic has not been studied in detail. We therefore investigated mortality risk post-acute COVID-19 CRIT-COV-U cohort. Methods: could retrieve survival data from 651 patients also assess association between urinary peptides future death. Data spanning until December 2023 were collected six...