A5034689878- Ion Transport and Channel Regulation
- Dialysis and Renal Disease Management
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Genetic and Kidney Cyst Diseases
- Metabolism and Genetic Disorders
- Renal and related cancers
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Shoulder Injury and Treatment
- Genetic Syndromes and Imprinting
- Tendon Structure and Treatment
- Sports injuries and prevention
- Amino Acid Enzymes and Metabolism
- Potassium and Related Disorders
- Orthopedic Surgery and Rehabilitation
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Birth, Development, and Health
- Parathyroid Disorders and Treatments
- Biomedical Research and Pathophysiology
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Hormonal Regulation and Hypertension
University of Campania "Luigi Vanvitelli"
2016-2025
Biogem
2016-2025
Instituto de Biomedicina y Genética Molecular de Valladolid
2025
Institute of Molecular Biology and Genetics
2025
Uppsala University
2024
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2024
University of Zurich
2023
University of Naples Federico II
2010-2022
Ospedale Policlinico San Martino
2022
Aarhus University
2022
Recommendations about structuring proteomic biomarker studies should increase the probability that such markers will be clinically useful.
The outcome of steroid-dependent or frequently relapsing nephrotic syndrome minimal change disease (MCD), mesangial proliferative GN (MesGN), FSGS may be poor and with major treatment toxicity. This academic, multicenter, off-on trial (ClinicalTrials.gov #NCT00981838) primarily evaluated the effects rituximab therapy followed by immunosuppression withdrawal on recurrence in 10 children 20 adults MCD/MesGN (n=22) who had suffered ≥2 recurrences over previous year were steroid-induced...
Lateral ankle sprains may result in pain and disability the short term, decreased sport activity early retirement from sports mid secondary injuries development of osteoarthritis to long term.This combined approach chronic lateral instability intra-articular lesions is safe term maintains mechanical stability, functional ability, a good level activity.Case series; Level evidence, 4.We present long-term outcomes 42 athletes who underwent arthroscopy anterior talofibular Broström repair for...
Abstract Background Metabolic acidosis is associated with accelerated progression of chronic kidney disease (CKD). Whether treatment metabolic sodium bicarbonate improves and patient survival in CKD unclear. Methods We conducted a randomized (ratio 1:1). open-label, controlled trial (NCT number: NCT01640119. www.clinicaltrials.gov ) to determine the effect patients stage 3–5 (SB) on creatinine doubling (primary endpoint), all-cause mortality time renal replacement therapy compared standard...
Objective To evaluate sensitivity, specificity, reproducibility, and predictive value of palpation the painful arc sign Royal London Hospital test in 10 patients with Achilles tendinopathy 14 asymptomatic subjects. Design Test-retest study. Setting University teaching hospital. Participants Ten male athletes on waiting list for exploration one their tendons main body tendon attended a special clinic. Each was invited to bring at least athlete same sex discipline aged within 2 years...
Transforming growth factor β (TGF-β) has been shown to participate in the pathophysiology of diabetic complications. As most recently, TGF-β stimulates expression a distinct serine/threonine kinase (hSGK) which had previously cloned as an early gene transcriptionally regulated by cell volume alterations. The present study was performed elucidate transcription and function hSGK nephropathy. Northern blotting, increase extracellular glucose concentration increased mRNA levels cultured cells,...
From August 1989 to January 1995 we performed multiple percutaneous longitudinal tenotomies under local anesthetic on 52 middle- and long-distance run ners with unilateral Achilles tendinitis or peritendinitis that had failed conservative treatment. Forty-eight pa tients were reviewed at an average of 22.1 months (SD, 6.5) after surgery. Results rated as excellent in 25 patients, good 12, fair 7, poor 4. Four patients developed subcutaneous hematomas. One patient a superficial infection one...
Several medial patellofemoral ligament reconstruction procedures have been proposed to manage recurrent patellar dislocation.Reconstruction of the using a hamstring graft with 2 transverse tunnels technique is an effective treatment for dislocation in patients without any evident predisposing factors.Case series; Level evidence, 4.Twenty-eight chronic instability anatomic factors, experiencing unilateral dislocation, were included study. Evaluation modified Cincinnati and Kujala scores,...
Bartter syndrome is a rare inherited salt-losing renal tubular disorder characterized by secondary hyperaldosteronism with hypokalemic and hypochloremic metabolic alkalosis low to normal blood pressure. The primary pathogenic mechanism defective salt reabsorption predominantly in the thick ascending limb of loop Henle. There significant variability clinical expression disease, which genetically heterogenous 5 different genes described date. Despite considerable phenotypic overlap,...
ABSTRACT Approval of the vasopressin V2 receptor antagonist tolvaptan—based on landmark TEMPO 3:4 trial—marked a transformation in management autosomal dominant polycystic kidney disease (ADPKD). This development has advanced patient care ADPKD from general measures to prevent progression chronic targeting disease-specific mechanisms. However, considering long-term nature this treatment, as well potential side effects, evidence-based approaches initiate treatment only patients with rapidly...
Fabry Disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene on X chromosome, leading to deficiency α-galactosidase A (AGAL) enzyme activity. This leads accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), vital organs such as kidneys, heart, and nervous system. While FD was initially considered predominantly affecting males, recent studies have uncovered that heterozygous women, carrying single mutated gene, can manifest wide array...
Patients with chronic kidney disease (CKD) often experience mild cognitive impairment and other neurocognitive disorders. Studies have shown that erythropoietin (EPO) its receptor neuroprotective effects in cell animal models of nervous system Recombinant human EPO (rHuEPO), commonly used to treat anemia CKD patients, could be a agent. In this systematic review, we aimed assess the published studies investigating benefits rHuEPO treatment individuals reduced function. We comprehensively...
TESTA, V., G. CAPASSO, F. BENAZZO, and N. MAFFULLI. Management of Achilles tendinopathy by ultrasound-guided percutaneous tenotomy. Med. Sci. Sports Exerc., Vol. 34, No. 4, pp. 573–580, 2002. Purpose To report the middle to long-term results longitudinal tenotomy tendon Method Seventy-five athletes with unilateral underwent under local anesthetic infiltration after failure conservative management. Sixty-three patients were reviewed at least 36 months operation (51 ± 18.2 months). Results...