A5082738088- Diet and metabolism studies
- Thyroid Cancer Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Thyroid Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Renal and related cancers
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Lysosomal Storage Disorders Research
- Renal cell carcinoma treatment
- Diabetes and associated disorders
- Digestive system and related health
- Growth Hormone and Insulin-like Growth Factors
- Gut microbiota and health
- Trypanosoma species research and implications
- Clinical Nutrition and Gastroenterology
- Advanced biosensing and bioanalysis techniques
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Potassium and Related Disorders
University of Campania "Luigi Vanvitelli"
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Casa Sollievo della Sofferenza
2024
University of Naples Federico II
2021
Fabry Disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene on X chromosome, leading to deficiency α-galactosidase A (AGAL) enzyme activity. This leads accumulation of glycosphingolipids, primarily globotriaosylceramide (Gb3), vital organs such as kidneys, heart, and nervous system. While FD was initially considered predominantly affecting males, recent studies have uncovered that heterozygous women, carrying single mutated gene, can manifest wide array...
In the last decade Sanger method of DNA sequencing has been replaced by next-generation (NGS). NGS is valuable in conditions characterized high genetic heterogeneity such as neonatal diabetes mellitus (NDM).
TRIM8 is an E3 ubiquitin ligase that functions as both a tumour suppressor and oncoprotein. Earlier, we reported interacts with key regulators of mitotic spindle assembly, knockdown results in delay aneuploidy. In this study, implemented multi-omics strategy differential transcriptomic (single-cell RNA sequencing or scRNA-seq), translatomic (polysome profiling RNA-seq), proteomic (LC-MS/MS) approaches to elucidate the involvement different levels (transcription, translation,...
Thyroid hormones (THs) are key regulators of different biological processes. Their action involves genomic and non-genomic mechanisms, which together mediate the final effects TH in target tissues. However, proportion two processes their contribution to TH-mediated still poorly understood. Skeletal muscle is a classical tissue for TH, regulates strength contraction, as well energetic metabolism myofibers. Here we address skeletal cells by specifically silencing deiodinase Dio2 or β3-Integrin...
Chronic kidney disease (CKD) induces several systemic effects including the accumulation and production of uremic toxins responsible for activation various damaging processes. The abundant discharge urea other waste substances in gut favors selection an altered microbiota patients with CKD. prevalence aerobic bacteria leads to release blood derived from tryptophan tyrosine metabolism, such as Indoxyl Sulphate (IS) P-cresyl sulphate (P-cs).
Abstract Background and Aims Chronic kidney disease (CKD) leads to the accumulation production of uremic toxins, such as Indoxyl Sulphate (IS) P-cresyl sulphate (p-CS). These toxins have been found activate various processes that promote tumor growth. The literature has reported a two-fold increase in incidence colon cancer (CRC) worse prognosis CKD patients, although specific mechanisms underlying this association not fully elucidated. Given pro-oncogenic activities p-CS IS at both systemic...