A5082728314- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related gene regulation
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Non-Invasive Vital Sign Monitoring
- Congenital Diaphragmatic Hernia Studies
- Neuroblastoma Research and Treatments
- Healthcare Technology and Patient Monitoring
- Genetic Associations and Epidemiology
- Growth Hormone and Insulin-like Growth Factors
- Congenital Ear and Nasal Anomalies
- Neuroendocrine Tumor Research Advances
- Chromatin Remodeling and Cancer
- Sarcoidosis and Beryllium Toxicity Research
- Histone Deacetylase Inhibitors Research
- Medical and Biological Ozone Research
University of Naples Federico II
2015-2025
University of Campania "Luigi Vanvitelli"
2019-2025
Institute for Experimental Endocrinology and Oncology
2015-2024
National Research Council
2014-2024
Azienda Ospedaliero-Universitaria Careggi
2021
Meyer Children's Hospital
2007-2020
University of Florence
1995-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2015
Institute for High Performance Computing and Networking
2014
York University
2002
// Francesco Esposito 1 , Marco De Martino Maria Grazia Petti Floriana Forzati Mara Tornincasa Antonella Federico Claudio Arra 2 Giovanna Pierantoni Alfredo Fusco Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento Medicina Molecolare e Biotecnologie Mediche, Scuola Chirurgia Napoli, Università degli Studi Napoli "Federico II", Naples, Italy. Nazionale dei Tumori, Fondazione Pascale, Correspondence to: Dr. Fusco, e-mail: alfusco@unina.it Key words: HMGA1P6, HMGA1P7,...
Numerous studies have established that High Mobility Group A (HMGA) proteins play a pivotal role on the onset of human pituitary tumors. They are overexpressed in tumors, and, consistently, transgenic mice overexpressing either Hmga1 or Hmga2 gene develop In contrast with HMGA2, HMGA1 overexpression is not related to any rearrangement amplification locus these We recently identified 2 pseudogenes, HMGA1P6 and HMGA1P7, acting as competitive endogenous RNA decoys for other cancer genes. Here,...
FOXM1 (forkhead box protein M1) is a transcription factor that participates in all stages of tumor development, mainly through the control cell cycle and proliferation, regulating expression genes involved G1/S G2/M transition M phase progression. The ubiquitin conjugating enzyme E2 (UBE2C) member anaphase promoting complex/cyclosome, degradation several target proteins along progression, during metaphase/anaphase transition. UBE2C have been found overexpressed wide range different solid...
Background/Objectives: The UbcH10 protein plays an important role in a variety of human malignancies, including thyroid, breast, ovarian, and colorectal carcinomas. It has been previously reported that is overexpressed non-small cell lung cancer (NSCLC) compared to normal lungs its expression directly inversely correlated with the mutational status p53 EGFR, respectively. Methods: We transfected cells wild-type mutant forms modulated p53, treated these tyrosine kinase inhibitor (TKI)...
Abstract Recent studies have revealed that pseudogene transcripts can function as competing endogenous RNAs, and thereby also contribute to cancer when dysregulated. We recently identified two pseudogenes, HMGA1P6 HMGA1P7 for the HMGA1 gene whose overexpression has a critical role in progression. These pseudogenes work competitive RNA decoys other related genes suggesting their carcinogenesis. Looking new ceRNAs, we performed sequencing technology on mouse embryonic fibroblasts deriving from...
The esophageal squamous cell carcinoma (ESCC) is widely known as a highly lethal and poor understood cancer, then requiring the search for novel molecular markers to improve its management patients survival. Recently, ubiquitin-conjugating enzyme E2C (UBE2C) has been figuring prominent tumor biomarker candidate, once it recognized key player in cycle progression. In this way, aim of study was evaluate expression profile UBE2C gene protein ESCC samples, well diagnostic prognostic marker...
Dosage-dependent upregulation of most chromosome 21 (Hsa21) genes has been demonstrated in heart tissues fetuses with Down syndrome (DS). Also miRNAs might play important roles the cardiac phenotype as they are highly expressed and regulate development. Five Hsa21 have well studied past: miR-99a-5p, miR-125b-2-5p, let-7c-5p, miR-155-5p, miR-802-5p but few information is available about their expression trisomic tissues. In this study, we evaluated these from DS fetuses, showing that...
MARTINO, M., N. GLEDHILL, and V. JAMNIK. High V̇O2max with no history of training is primarily due to high blood volume. Med. Sci. Sports Exerc., Vol. 34, No. 6, pp. 966–971, 2002. Purpose To investigate the observed occasionally in young men who have training. Methods V̇O2max, volume (BV), maximal stroke (SVmax), cardiac output (𝑄̇max), related measurements (reported as mean ± SEM) were studied six (mean age 20.0 0.5 yr) training, all had a below 49 mL·kg−1·min−1 (LO group) age-...
// Antonio Palumbo Jr 1, 2 , Nathalia Meireles Da Costa 1 Francesco Esposito 3 Marco De Martino Daniela D'Angelo Vanessa Paiva Leite de Sousa Ivanir Martins 4 Luiz Eurico Nasciutti Alfredo Fusco Luis Felipe Ribeiro Pinto Programa Carcinogênese Molecular, Instituto Nacional Câncer - INCA, Rio Janeiro, RJ, Brazil Laboratório Interações Celulares, Ciências Biomédicas, Universidade Federal do Janeiro Prédio da Saúde Cidade Universitária, Ilha Fundão, Istituto di Endocrinologia e Oncologia...
Glioblastoma (GBM) is a lethal, fast-growing brain cancer, affecting 2-3 per 100,000 adults year. It arises from multipotent neural stem cells which have reduced their ability to divide asymmetrically and hence symmetrically, generating increasing number of cancer cells, fostering tumor growth. We previously demonstrated that the architectural transcription factor HMGA1 highly expressed in (BTSCs) its silencing increases cell quiescence, reduces self-renewal sphere-forming efficiency serial...
Background: Recent studies have underlined HMGA protein’s key role in the onset of testicular germ cell tumors, where HMGA1 is differently expressed with respect to state differentiation, suggesting its fine regulation as master regulator tumorigenesis. Several highlighted that transcript strictly regulated by a set inhibitory microRNAs. Thus, aim this study test whether overexpression human seminomas may be induced deregulation miR-26a and Let-7a—two HMGA1-targeting Methods: mRNA Let-7a...
Loss of CBX7 expression has been described in several malignant neoplasias, including human colon and thyroid carcinomas proposing as a tumor suppressor gene with key role cancer progression. This is supported from the development benign neoplasias Cbx7 null mice. The aim our work to investigate mechanisms underlying oncosuppressor activity by analyzing microRNAs (miRNAs) regulated CBX7. miRNA profiles mouse embryonic fibroblasts (MEFs) for wild-type counterpart were analyzed miRNACHIP...
Several studies have established that pseudogene mRNAs can work as competing endogenous RNAs and, when deregulated, play a key role in the onset of human neoplasias. Recently, we isolated two HMGA1 pseudogenes, HMGA1P6 and HMGA1P7. These pseudogenes critical cancer progression, acting micro RNA (miRNA) sponges for other cancer-related genes. were found overexpressed several carcinomas, their expression levels positively correlate with an advanced stage poor prognosis. In order to investigate...
Endometrioid endometrial carcinomas (EEC) are the most common malignant gynecologic tumors. Despite increase in EEC molecular knowledge, identification of new biomarkers involved disease’s development and/or progression would represent an improvement its course. High-mobility group A protein (HMGA) family members frequently overexpressed a wide range malignancies, correlating with poor prognosis. Thus, aim this study was to analyze HMGA1 and HMGA2 expression pattern their potential role as...
Malignant tumours from the upper aerodigestive tract are grouped collectively in class of head and neck squamous cell carcinoma (HNSCC). The were responsible for more than 500 000 cancer cases 2012, accounting sixth highest incidence rate mortality worldwide among all tumour types. Laryngeal (LSCC) possesses second HNSCC. Despite significant advances surgery radiotherapy during last few decades, no treatment has been shown to achieve a satisfactory therapeutic outcome LSCC is still high,...
DICER1 plays a central role in the biogenesis of microRNAs and it is important for normal development. Altered microRNA expression dysregulation have been described several types tumors, including thyroid carcinomas. Recently, our group identified new somatic mutation (c.5438A>G; E1813G) within gene an unknown function. Herein, we show that overexpressed, at mRNA level, significant-relative number papillary (70%) anaplastic (42%) carcinoma samples, whereas drastically downregulated all...