A5030967291- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Endometrial and Cervical Cancer Treatments
- BRCA gene mutations in cancer
- Genomics, phytochemicals, and oxidative stress
- Nutrition, Genetics, and Disease
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Metalloenzymes and iron-sulfur proteins
- Glutathione Transferases and Polymorphisms
- Cancer Risks and Factors
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Genomics and Phylogenetic Studies
- FOXO transcription factor regulation
- Monoclonal and Polyclonal Antibodies Research
- Wnt/β-catenin signaling in development and cancer
- Plant-Derived Bioactive Compounds
Universidade do Estado do Rio de Janeiro
2013-2024
Instituto Nacional do Câncer
2008-2023
Northern State University
2019
Creative Research Enterprises (United States)
2016
Hospital Universitário Pedro Ernesto
2016
Abstract Background Gluconacetobacter diazotrophicus Pal5 is an endophytic diazotrophic bacterium that lives in association with sugarcane plants. It has important biotechnological features such as nitrogen fixation, plant growth promotion, sugar metabolism pathways, secretion of organic acids, synthesis auxin and the occurrence bacteriocins. Results third to be completely sequenced. Its genome composed a 3.9 Mb chromosome 2 plasmids 16.6 38.8 kb, respectively. We annotated 3,938 coding...
Esophageal squamous cell carcinoma (ESCC) is believed to arise from esophageal mucosa through accumulation of both genetic and epigenetic changes. DNA methylation a critical mechanism involved in key cellular processes its deregulation has been linked many human cancers, including ESCC. The aim this study examine the global states ESCC identify potential early biomarkers. With purpose, we performed bead array analysis more than 800 cancer-related genes ten samples, matched surrounding...
FOXM1 (forkhead box protein M1) is a transcription factor that participates in all stages of tumor development, mainly through the control cell cycle and proliferation, regulating expression genes involved G1/S G2/M transition M phase progression. The ubiquitin conjugating enzyme E2 (UBE2C) member anaphase promoting complex/cyclosome, degradation several target proteins along progression, during metaphase/anaphase transition. UBE2C have been found overexpressed wide range different solid...
The role of HPV in esophageal squamous cell carcinoma (ESCCs) is controversial. Therefore, we determined, through different methodologies, the prevalence 264 ESCC samples from Brazil, and correlated it with presence surrogate markers clinicopathological characteristics. present 13% ESCC, a 3-fold variation between high medium incidence areas. Most positive tumors were infected HPV16, but this was not associated p16 expression, TP53 mutation status, patient age, amount tobacco or alcohol...
BackgroundV-ATPases are hetero-oligomeric enzymes consisting of 13 subunits and playing key roles in ion homeostasis signaling. Differential expression these proton pumps has been implicated carcinogenesis metastasis. To elucidate putative molecular signatures underlying phenomena, we evaluated the V-ATPase genes esophageal squamous cell carcinoma (ESCC) extended analysis to other cancers.MethodsExpression all were analyzed ESCC by a microarray data different types tumors available from...
Endometrioid endometrial carcinomas (EEC) are the most common malignant gynecologic tumors. Despite increase in EEC molecular knowledge, identification of new biomarkers involved disease’s development and/or progression would represent an improvement its course. High-mobility group A protein (HMGA) family members frequently overexpressed a wide range malignancies, correlating with poor prognosis. Thus, aim this study was to analyze HMGA1 and HMGA2 expression pattern their potential role as...
Laryngeal squamous cell carcinoma (LSCC) is one of the most incident tumors in world, especially developing countries, such as Brazil. Different from other tumors, LSCC prognosis did not improve during past four decades. Therefore, objective this study was to develop biomarkers that can predict patient's prognosis. Transcriptome analysis pointed out 287 overexpressed genes comparison adjacent mucosa. Among these, a gene-pattern signature created with 24 associated The Bayesian clustering...
Esophageal squamous cell carcinoma (ESCC) is one of the 10 most incident cancer types in world, and it mainly associated with tobacco alcohol consumption. ESCC mortality rates stand very close to its incidence, which a direct consequence late diagnosis an inefficient treatment. Although this scenery quite alarming, major molecular alterations that drive carcinogenesis process remain unclear. We have previously shown through first methylome analysis TFF1 promoter frequently hypermethylated...
Upper aerodigestive tract (UADT) tumors present different biological behavior and prognosis, suggesting specific molecular mechanisms underlying their development. However, they are rarely considered as single entities (particularly head neck subsites) share the most common genetic alterations. Therefore, there is a need for better understanding of global DNA methylation differences among UADT tumors. We performed genome-wide analysis esophageal (ESCC), laryngeal (LSCC), oral (OSCC)...
Oesophageal squamous cell carcinoma (ESCC) is one of the most common malignancies and sixth cause cancer-related death in world. Inactivation cell-cycle regulating genes, such as p14ARF p16INK4a, adhesion E-cadherin, cancer, results from genetic and/or epigenetic alterations. Therefore, we have analysed mRNA expression p14ARF, p16INK4a E-cadherin 17 matched ESCC normal mucosal samples obtained Brazilian patients by semi-quantitative RT-PCR. The was absent or reduced several samples....
Abstract Esophageal squamous cell carcinoma (ESCA) exhibits high intratumoral molecular heterogeneity posing a challenge to cancer therapy. Immune checkpoint blockade therapy has been approved for this disease, but with modest results. RNA-Seq data from paired tumor and surrounding nonmalignant tissue 14 patients diagnosed ESCA without previous treatment The Cancer Genome Atlas-ESCA cohort were analyzed. Herein, we investigated immune landscape including mutation-derived neoantigens...
Esophageal squamous cell carcinoma (ESCC) is a frequent and lethal neoplasia. As recent advances in targeted therapy have not improved ESCC prognosis, characterization of molecular alterations associated to this tumor foremost relevance. In study, we analyze, for the first time, complete genomic profile by RNA-seq. TP53 was most frequently mutated gene investigation validation sets (78.6% 67.4%, respectively). Differential expression analysis between nontumor adjacent mucosa showed 6698...
The majority of endometrioid endometrial carcinomas (EEC) is diagnosed at stage I. Among these, 30% present myometrial invasion (stage IB), which associated with tumor spread and relapse after primary treatment. Although an increased expression RUNX1/AML1 ERM/ETV5 in EEC have been suggested to be early events infiltration, there no data regarding its along the evolution possible associations other clinicopathological parameters. Therefore, protein gene profiles were assessed different stages...
Plant-derived compounds are important sources of effective anti-cancer agents. Pterodon pubescens is a native Brazilian plant popularly known for its anti-inflammatory and anti-arthritic effects. The ethanolic extract seeds (EEPp) viscous, brown fragrant oil containing geranylgeraniol, farnesol, naphthalene, dimethyldodecatrienol vouacapan diterpene derivatives, in addition to other compounds. This study investigated the vitro anti-leukemic properties EEPp using resistant human leukemia cell...
Abstract Forensic strategies commonly are proceeding by analysis of short tandem repeats ( STR s); however, new additional have been proposed for forensic science. Thus, this article standardized the high‐resolution melting HRM ) DNA analyzes. For , mitochondrial (mt from eight individuals were extracted mucosa swabs zol reagent, samples amplified PCR and submitted to identify differences in hypervariable HV regions I II . To confirm all products sequencing. The data suggest that is possible...
To obtain a better understanding of the mechanisms involved in up-regulation Fas apoptotic signaling cascade induced by P. aeruginosa type III secretion system (TTSS), human umbilical vein endothelial cells (HUVEC) were infected with PAO-1 or its TTSS-negative mutant PAO-1::exsA. was significantly more cytotoxic than and features apoptosis (DNA fragmentation annexin V reactivity) prominent cultures wild-type bacteria. release soluble FasL (sFasL) from but cell treatment antagonist anti-Fas...