A5030267916- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Bone Tissue Engineering Materials
- Ear and Head Tumors
- Temporomandibular Joint Disorders
- Antibiotic Resistance in Bacteria
- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Infections and bacterial resistance
- Molecular Biology Techniques and Applications
- Dental Implant Techniques and Outcomes
- Laser Applications in Dentistry and Medicine
- AI in cancer detection
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Multiple Myeloma Research and Treatments
- Head and Neck Surgical Oncology
- Bone and Dental Protein Studies
- Dental Erosion and Treatment
- RNA modifications and cancer
- Periodontal Regeneration and Treatments
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Cell Image Analysis Techniques
Universidade Federal Fluminense
2007-2019
Instituto Nacional do Câncer
2008-2019
Universidade do Estado do Rio de Janeiro
2014-2019
Hospital Universitário Antônio Pedro
2009
Angiogenesis is a proliferative process resulting in the development of new blood vessels from existing endothelial cells and considered crucial for tumor growth metastasis. Tumor angiogenesis can be quantified by microvascular density (MVD), which evaluated highly vascularized areas (hot spots) immunohistochemical assays using CD34 CD31 pan-endothelial antibodies. More recently, CD105 has been successfully used some types because it could discriminate neovascularization. The expression...
SUMMARY Achromobacter spp. are opportunistic pathogens increasingly recovered from adult patients with cystic fibrosis (CF). We report the characterization of 122 isolates 39 CF by multilocus sequence typing, virulence traits, and susceptibility to antimicrobials. Two species, A. xylosoxidans (77%) ruhlandii (23%) were identified. All showed a similar biofilm formation ability, positive swimming phenotype. By contrast, 4·3% 44·4% , respectively, exhibited negative swarming phenotype, making...
Background Multidrug resistance is a critical factor in tuberculosis control. To gain better understanding of multidrug resistant Brazil, retrospective study was performed to compare genotypic diversity and drug associated mutations Mycobacterium isolates from national reference center. Methods Findings Ninety-nine 12 Brazilian states were studied. Drug-resistance patterns determined the rpoB katG genes screened for mutations. Genotypic investigated by IS6110-RFLP Luminex 47 spoligotyping....
Abstract Quantification of immunostaining is a widely used technique in pathology. Nonetheless, techniques that rely on human vision are prone to inter- and intraobserver variability, they tedious time consuming. Digital image analysis (DIA), now available variety platforms, improves quantification performance: however, the stability these different DIA systems largely unknown. Here, we describe method measure reproducibility systems. In addition, new image-processing strategy for...
Pathological parameters have been indicated as tumor prognostic factors in oral carcinoma.The objective of this study was to investigate the impact pathological on prognosis patients affected only by tongue and/or floor mouth squamous cell carcinoma (SCC).In total, 380 treated Brazilian National Cancer Institute (INCA) from 1999 2006 were included. These underwent radical resection followed neck dissection. The clinical and characteristics recorded. Kaplan-Meier method Cox proportional...
ABSTRACT Objective To assess the presence of bruxism and anxiety among military firefighters with frequent episodic tension-type headache painful temporomandibular disorders (TMDs). Methods The sample consisted 162 individuals aged 18 to 55 years divided into four groups. Headache was diagnosed in accordance International Classification Disorders-III. Research Diagnostic Criteria for Temporomandibular Disorders questionnaire used classify TMDs awake bruxism; sleep Sleep Disorders-3;...
Biomaterials for treatment of bone defects have been studied a long time. Alloplastic materials, mainly hydroxyapatite (HA), are under intense investigation due to its biocompatibility and osteoconductive properties. The HA can be modified by the incorporation bivalent cations as Zn2+ known positive effectors repair. purpose this study was evaluate comparatively effectiveness 5% zinc-containing (ZnHA) in critical size defect (CSD) rat’s calvaria. CSD (8mm diameter) created skull forty-five...
Background: It has been suggested that the donor tissue cores used in microarrays (TMAs) may not be representative of whole section. Aim: To validate use TMA technology study malignant peripheral nerve sheath tumours (MPNSTs). Methods: A was constructed containing five independent core biopsy samples 14 formalin-fixed, paraffin-embedded MPNSTs. The immunohistochemical (IHC) results from same block on were compared with readings sections using two antibodies: anti-Ki-67 and anti-S-100....
This study aimed to evaluate apoptosis by assessing cleaved caspase-3 immunoexpression in hyperplastic, potentially malignant disorder (PMD), and tumors intraoral lower lip sites.A retrospective using paraffin blocks with tissues from patients inflammatory fibrous hyperplasia (IFH), actinic cheilitis, oral leukoplakia, squamous cell carcinoma (SCC) was performed. The were evaluated immunohistochemical analysis anti-cleaved antibody. Apoptotic area index then correlated lesion type.From 120...
As plaquetas são fragmentos citoplasmáticos anucleados presentes no sangue e produzidos na medula óssea a partir dos megacariócitos. O objetivo deste trabalho é rever as bases mecanísticas moleculares das plaquetas, revelando sua participação em síndromes importantes trombose arterial, além de seu potencial como alvo terapêutico para o desenho novos agentes antitrombóticos.
The clinical relevance of Achromobacter xylosoxidans infection in cystic fibrosis (CF) remains controversial. This emerging agent CF has been associated with increased lung inflammation, more frequent exacerbations and severe disease. We describe a pair siblings chronically colonized by the same multilocus genotype A. different courses, assess whether this species may have developed any virulence traits antimicrobial resistance that could contributed to their singular outcomes.Two were...
O sistema de estadiamento clínico tumores TNM tem sido a classificação adotada para caracterizar os tumores, propor terapia mais adequada e estimar sobrevida dos pacientes. As informações obtidas através exames imagem são utilizadas estabelecer o estádio (cTNM) e, caso paciente seja submetido à cirurgia, determina-se patológico (pTNM) mediante exame histopatológico do tumor linfonodos regionais. Entretanto clinicamente precoces, mesmo tratados adequadamente, podem causar morte paciente....
The objective of the present study was to evaluate quality and intensity tissue response two synthetic hydroxyapatites implanted in critical defects skulls rats. Sixty animals were divided into three experimental groups: I (control), II (HA-1 = HA with 28% crystallinity) III (HA-2 70% crystallinity). They sacrificed 1, 3, 6, 9 months after implantation (n 5 individuals per group/period). Histomorphometric analysis included i) counting polymorphonuclear leucocytes, mast cells, macrophages...
INTRODUÇÃO: A carcinogênese caracteriza-se como um processo multifatorial, e a inativação da proteína p53 é uma alteração genética comumente observada nos carcinomas de células escamosas boca (CCEB). OBJETIVO: Analisar comparar imunoexpressão p53, por meio dos clones DO-7 PAb-240, em CCEB com localização intrabucal lábio inferior. MATERIAL E MÉTODOS: Foram selecionados 40 casos CCEB, sendo 20 Foi realizado estudo imuno-histoquímico utilizando os anticorpos anti-p53 clone PAb-240....
<b><i>Background/Aim:</i></b> The <i>TP53</i> gene is a tumor suppressor gene. Its product nuclear protein that regulates cell cycle arrest, apoptosis and DNA repair. Anti-p53 clones DO-7 PAb-240 recognize the amino acid sequences 21-25 213-217, respectively. This study aimed to evaluate expression of these their relationship with clinicopathological features survival analysis in oral squamous carcinomas (OSCC)....
The aim of this paper was to evaluate the usefulness coupling digital image analysis with immunohistochemistry and histomorphometry data study tissue response hydroxyapatite in a model critical size bone defect calvaria rats. A transosseous measuring 8 mm diameter performed surgical trephine parietal 40 rats divided into two experimental groups according treatment: group I (blood clot, control), II (HA) killed 1, 3, 6 9 months after implantation (n=5/group/period). skullcaps overlaying skin...
Paschoal, J. V.; Caroli-Bottino, A.; Canedo, N.; Monteiro, B.; Bernardo, Pannain, V. L. Author Information