A5103101032- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Health Education and Validation
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Dysphagia Assessment and Management
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Women's cancer prevention and management
- Metastasis and carcinoma case studies
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
- Science and Education Research
- Physical Education and Gymnastics
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
- Anesthesia and Sedative Agents
- Abdominal Surgery and Complications
- Digestive system and related health
- Water Treatment and Disinfection
- FOXO transcription factor regulation
- Tumors and Oncological Cases
- RNA modifications and cancer
- Nasal Surgery and Airway Studies
- Academic Research in Diverse Fields
Universidade Federal do Rio Grande do Sul
1999-2020
Hospital de Clínicas de Porto Alegre
2012
Esophageal squamous cell carcinoma (ESCC) is believed to arise from esophageal mucosa through accumulation of both genetic and epigenetic changes. DNA methylation a critical mechanism involved in key cellular processes its deregulation has been linked many human cancers, including ESCC. The aim this study examine the global states ESCC identify potential early biomarkers. With purpose, we performed bead array analysis more than 800 cancer-related genes ten samples, matched surrounding...
Diagnosis of squamous cell carcinoma the esophagus is usually late. Staining mucosa with Lugol's solution during endoscopy has been suggested to identify early cancer/dysplasia and may improve prognosis. Lugol was tested in 96 asymptomatic subjects at risk for this tumor, who were found have atypias after exfoliative cytology southern Brazil. Biopsies obtained 'stained' 'unstained' areas esophageal histologic results compared. 'Unstained' present 64 (66.7%) instances: 44 over normal...
The esophageal squamous cell carcinoma (ESCC) is widely known as a highly lethal and poor understood cancer, then requiring the search for novel molecular markers to improve its management patients survival. Recently, ubiquitin-conjugating enzyme E2C (UBE2C) has been figuring prominent tumor biomarker candidate, once it recognized key player in cycle progression. In this way, aim of study was evaluate expression profile UBE2C gene protein ESCC samples, well diagnostic prognostic marker...
The role of HPV in esophageal squamous cell carcinoma (ESCCs) is controversial. Therefore, we determined, through different methodologies, the prevalence 264 ESCC samples from Brazil, and correlated it with presence surrogate markers clinicopathological characteristics. present 13% ESCC, a 3-fold variation between high medium incidence areas. Most positive tumors were infected HPV16, but this was not associated p16 expression, TP53 mutation status, patient age, amount tobacco or alcohol...
Esophageal squamous cell carcinoma (ESCC) presents poor prognosis, and patients diagnosed with this tumor currently lack target treatments. Therefore, in order to identify potential targets for ESCC treatment, we carried out a transcriptome analysis paired nonmalignant surrounding mucosa samples, followed by master regulator analysis, further explored the role of identified central regulatory genes through vivo vitro assays. Among transcription factors deregulated/enriched ESCC, focused on...
The most common genetic alterations found in a wide variety of cancers are p53 tumor suppressor gene mutations. appears to be nuclear transcription factor that plays role the control cell proliferation, apoptosis, and maintenance stability. Angiogenesis is critical process solid growth metastasis. Vascular endothelial (VEGF), recently identified with significant angiogenic properties, may major angiogenesis regulator. Few studies have investigated association between VEGF expressions...
Studies in human beings and animals have shown that esophageal exposure to duodenal gastric contents may be important for the development of Barrett's esophagus its complications, including adenocarcinoma epidermoid carcinoma. Diethylnitrosamine (DEN) is a carcinogen stimulates carcinoma mice. The aim this study was evaluate effect gastroduodenal content reflux on induction carcinogenesis. Gastroesophageal (GER) gastroduodenoesophageal (GDER) were produced by cardioplasty...
To correlate the expression of p53 protein and VEGF with prognosis patients submitted to curative resection treat esophageal adenocarcinoma.Forty-six adenocarcinoma, resection, were studied. The expressions assessed by immunohistochemistry in 52.2% 47.8% tumors, respectively.P53 coincided 26% cases, no correlation between these was observed. None clinicopathological factors showed a significant or expressions. There association long-term survival.The did not adenocarcinoma resection.
It is known that some nitrosamines preferably affect particular organs because of their organospecificity. Diethylnitrosamine (DEN) one the most powerful for experimentally inducing esophagus cancer. The present study aimed to evaluate rate and type epithelial lesions induced by DEN in mice. We also assessed role alcohol N-nitrosonornicotine (NNN) as promoters this carcinogenesis. A total 208 female mice (Mus musculus) were allocated five experimental groups: group 1, water only (controls);...
ABSTRACT Background: Southern Brazil has one of the highest incidences esophageal squamous cell carcinoma in world. Transthoracic esophagectomy allows more complete abdominal and thoracic lymphadenectomy than transhiatal. However, this is associated with less morbidity. Aim: To analyze outcomes prognostic factors cancer treated transhiatal procedure. Methods: All patients selected for approach were included as a potentially curative treatment overall survival, operative time, lymph node...
RACIONAL: O tratamento cirúrgico do divertículo de Zenker inclui na maioria dos casos a cricomiotomia músculo cricofaríngeo, qual pode ser associada à diverticulopexia ou diverticulectomia. A escolha destas opções cirúrgicas ainda é controversa. OBJETIVO: Avaliar os resultados dois tratamentos cirúrgicos (diverticulopexia diverticulectomia, ambos associados cricomiotomia) em uma série casos. MÉTODOS: Estudo retrospectivo período 10 anos 26 pacientes submetidos ao Zenker. Para análise...
RACIONAL: O refluxo duodenogástrico tem sido implicado como potencial carcinógeno para o estômago e esôfago é um dos fatores que podem explicar desenvolvimento de câncer no coto gástrico. Modelos experimentais carcinogênese ressecado ou nas gastrojejunoanastomoses estão bem definidos. OBJETIVOS: Desenvolver modelo experimental gástrica através piloroplastia à Finney, avaliar a influência da ingestão nitrito sódio nesse modelo, analisar as concentrações ácidos biliares valor do pH MÉTODOS:...
OBJETIVO: Testar o lumiracoxibe, utilizado preemptivamente contra um placebo, e analisar consumo de analgésicos (dipirona tramadol) nas primeiras 24h do pós-operatório. MÉTODOS: Sessenta pacientes submetidas à mamoplastia aumento, sob anestesia peridural, foram selecionadas divididas forma randomizada em dois grupos - GI GII. minutos antes da operação, por via oral, as 30 receberam comprimido lumiracoxibe 400mg, GII placebo. A dor pós-operatória foi avaliada através escala analógica visual,...
CONTEXT: Barrett's esophagus is characterized by the presence of goblet cells. However, when alcian-blue utilized, another type cells, called columnar blue frequently present in distal patients with endoscopic evidence esophagus. Cytokeratin 7 and 20 immunoreactivity has been previously studied areas intestinal metaplasia at esophagogastric junction. expression these cytokeratins cells not characterized. OBJECTIVE: To compare cytokeratin METHODS: Biopsies from 86 were evaluated. The biopsies...
Abstract Background Neoadjuvant treatment of esophageal cancer is world accepted since 2012 (1), showing benefits in long-term survival. However, there still controversy relating to potential complications with the use antineoplastic drugs and radiotherapy, notably because higher incidence cervical leak. Our study describes a five-year experience anastomotic leaks esophagectomies after neoadjuvant therapy southern Brazilian referral center. Methods We have analyzed all patients submitted...