A5018082289- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genomics and Chromatin Dynamics
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Renin-Angiotensin System Studies
- Esophageal Cancer Research and Treatment
- RNA Research and Splicing
German Cancer Research Center
2024
University Hospital Carl Gustav Carus
2024
Technische Universität Dresden
2024
National Center for Tumor Diseases
2024
Heidelberg University
2018-2024
Helmholtz-Zentrum Dresden-Rossendorf
2024
Institute for Experimental Endocrinology and Oncology
2016-2019
University of Naples Federico II
2016-2019
University Medical Centre Mannheim
2018
University Hospital Heidelberg
2018
Glioblastoma multiforme (GBM) develops from a small subpopulation of stem-like cells, which are endowed with the ability to self-renew, proliferate and give rise progeny multiple neuroepithelial lineages. These cells resistant conventional chemo- radiotherapy hence also responsible for tumor recurrence. HMGA1 overexpression has been shown correlate proliferation, invasion, angiogenesis GBMs affect self-renewal cancer stem colon cancer. The role in GBM is not completely understood.We have...
Glioblastoma (GBM) is a lethal, fast-growing brain cancer, affecting 2-3 per 100,000 adults year. It arises from multipotent neural stem cells which have reduced their ability to divide asymmetrically and hence symmetrically, generating increasing number of cancer cells, fostering tumor growth. We previously demonstrated that the architectural transcription factor HMGA1 highly expressed in (BTSCs) its silencing increases cell quiescence, reduces self-renewal sphere-forming efficiency serial...
Abstract Objective In the era of image-guided adaptive radiotherapy, definition clinical target volume (CTV) is a challenge in various solid tumors, including esophageal cancer (EC). Many tumor microenvironmental factors, e.g., cell proliferation or stem cells, are hypothesized to be involved microscopic extension (MTE). Therefore, this study assessed expression FAK, ILK, CD44, HIF-1α, and Ki67 EC patients after neoadjuvant radiochemotherapy followed by resection (NRCHT+R) correlated these...