A5074342073- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Celiac Disease Research and Management
- Microscopic Colitis
- Eosinophilic Esophagitis
- Diabetes Treatment and Management
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Inflammatory Bowel Disease
- Galectins and Cancer Biology
- Intestinal Malrotation and Obstruction Disorders
- Endoplasmic Reticulum Stress and Disease
- Oral Health Pathology and Treatment
- COVID-19 Clinical Research Studies
- Genetic factors in colorectal cancer
- Infant Nutrition and Health
- T-cell and B-cell Immunology
- Obesity, Physical Activity, Diet
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2025
University of Naples Federico II
2004-2025
Hospital General Universitario de Elche
2024
Semnan University of Medical Sciences
2024
Cornell University
2024
University of Virginia
2024
Rutgers, The State University of New Jersey
2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2024
IRCCS Ospedale San Raffaele
2014-2024
We conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe 7.1), preschool children, treatment according ISPAD protocol, type of rehydrating solution used, bicarbonates use, amount insulin infused. Records<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo...
Non-celiac gluten sensitivity (NCGS) is still an undefined syndrome with several unsettled issues despite the increasing awareness of its existence. We carried out a prospective survey on NCGS in Italian centers for diagnosis gluten-related disorders, aim defining clinical picture this new and to establish roughly prevalence compared celiac disease. From November 2012 October 2013, 38 (27 adult gastroenterology, 5 internal medicine, 4 pediatrics, 2 allergy) participated survey. A...
OBJECTIVE To evaluate whether the diagnosis of pediatric type 1 diabetes or its acute complications changed during early phase coronavirus disease 2019 (COVID-19) pandemic in Italy. RESEARCH DESIGN AND METHODS This was a cross-sectional, web-based survey all Italian centers to collect diabetes, diabetic ketoacidosis (DKA), and COVID-19 data patients presenting with new-onset established between 20 February 14 April 2020. RESULTS Fifty-three 68 (77.9%) responded. There 23% reduction new cases...
To investigate the prevalence of celiac disease in a large cohort children and adolescents at onset type 1 diabetes occurrence new cases during 6-year follow-up.We prospectively studied, by repeated serologic screening, 274 consecutive patients (age [mean +/- standard deviation]: 8.28 4.65 years) for 6 subsequent years. One patient had diagnosis before diabetes. The immunoglobulin A-antiendomysium antibody test was selected as screening test; with positive results (++ or +++) 2 weak tests...
Human type 1 diabetes (T1D) is an autoimmune disease associated with major histocompatibility complex polymorphisms, β-cell autoantibodies, and autoreactive T cells. However, there increasing evidence that innate cells may also play critical roles in T1D. We aimed to monitor peripheral immune early stages of T1D (i.e., healthy autoantibody-positive subjects) more advanced phases the at onset years after diagnosis). found a mild but significant reproducible neutropenia both precedes...
KCNJ11 mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term unclear. Sulfonylurea failure seen about 44% people type 2 after 5 years treatment. Therefore, we did a 10-year multicentre follow-up study large international cohort address key questions relating...
Until early 2000, permanent and transient neonatal diabetes mellitus (NDM), defined as with onset within 6 weeks from birth that requires insulin therapy for at least 2 weeks, were considered exceedingly rare conditions, a global incidence of 1:500,000–1:400,000 live births. The new definition NDM recently adopted, includes patients months age, has prompted studies have set the form alone between 1:210,000 1:260,000 Aim present work was to ascertain (i.e. + form) in Italy years 2005–2010....
Increasing evidences suggest a correlation between gut and type 1 diabetes (T1D). The objective of this study is to evaluate the inflammatory profile microbiota in patients with T1D compared healthy control (CTRL) subjects celiac disease (CD) as controls. status microbiome composition were evaluated biopsies duodenal mucosa (n = 19), CD CTRL 16) recruited at San Raffaele Scientific Institute, Milan, Italy, 2009 2015. Inflammation was by gene expression immunohistochemistry. Microbiome...
OBJECTIVE The Pediatric Artificial Pancreas (PedArPan) project tested a children-specific version of the modular model predictive control (MMPC) algorithm in 5- to 9-year-old children during camp. RESEARCH DESIGN AND METHODS A total 30 children, 9-years old, with type 1 diabetes completed an outpatient, open-label, randomized, crossover trial. Three days artificial pancreas (AP) were compared three parent-managed sensor-augmented pump (SAP). RESULTS Overnight time-in-hypoglycemia was reduced...
Background: The aim of this multicenter observational real-world study was to investigate glycemic outcomes in children and adolescents with type 1 diabetes over the first 6-month use MiniMed™ 780G. secondary objective evaluate demographic clinical factors that may be significantly associated achievement therapeutic goals. Methods: Demographic, anamnestic, data participants were collected at time enrollment. Data on ambulatory glucose profile acquired 3 6 months after activating automatic...
Glycemia risk index (GRI) is a novel composite metric for the evaluation of safety glycemic management and control. The aim this study was to evaluate GRI its correlations with continuous glucose monitoring (CGM) metrics by analyzing real-life CGM data in 1067 children/adolescents type 1 diabetes (T1D) using four different treatment strategies (intermittently scanned [isCGM]-multiple daily injections [MDIs]; real-time CGM-MDIs; rtCGM-insulin pump; hybrid closed-loop [HCL] therapy)....
OBJECTIVE To investigate glucose metrics and identify potential predictors of the achievement glycemic outcomes in children adolescents during their first 12 months MiniMed 780G use. RESEARCH DESIGN AND METHODS This multicenter, longitudinal, real-world study recruited 368 with type 1 diabetes (T1D) starting SmartGuard technology between June 2020 2022. Ambulatory profile data were collected a 15-day run-in period (baseline), 2 weeks after automatic mode activation, every 3 months. The...
Abstract Identifying β cell autoantigen-reactive T cells that are involved in the pathogenesis of type 1 diabetes has been troublesome for many laboratories. Disease-relevant autoreactive should be vivo Ag experienced. The aim this study was to test hypothesis and then use principle as a strategy identifying diabetes-relevant cells. In study, CSFE dilution assay used detect glutamic acid decarboxylase 65 (GAD65)- insulin-responsive HLA-0201*-GAD65114–122 pentamers were CD8+ GAD-responsive...
Obese adolescents are at risk of developing NAFLD and type 2 diabetes. We measured noninvasively the IHF content obese to ascertain whether it is associated with insulin resistance abnormal energy homeostasis. content, whole body homeostasis, sensitivity, composition were using localized hepatic (1)H-MRS, indirect calorimetry, fasting-derived 3-h-OGTT-derived surrogate indexes (HOMA2 WBISI), DEXA, respectively, in 54 (24 female 30 male, age 13 +/- yr, BMI >99th percentile for their sex)....
Celiac disease (CD) is a condition in which the regulation of mucosal immune response to dietary gliadin might be altered. The transcription factor forkhead box P3 (Foxp3) has been identified as marker subset regulatory T cells (Treg). In this study, we have investigated presence and suppressive function Treg celiac small intestinal mucosa, their correlation with state, inducibility by an organ culture system; moreover, tried define whether interleukin 15 (IL-15), overexpressed CD, could...