A5027769276- Celiac Disease Research and Management
- Cystic Fibrosis Research Advances
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Digestive system and related health
- Child Nutrition and Feeding Issues
- Gastroesophageal reflux and treatments
- Inflammatory Bowel Disease
- Neonatal Respiratory Health Research
- Infant Health and Development
- Immunodeficiency and Autoimmune Disorders
- Viral gastroenteritis research and epidemiology
- Food Allergy and Anaphylaxis Research
- Water Quality Monitoring and Analysis
- Bioinformatics and Genomic Networks
- Microbial Metabolites in Food Biotechnology
- Autoimmune Bullous Skin Diseases
- Marine and coastal ecosystems
- Microbial Metabolic Engineering and Bioproduction
- Intestinal Malrotation and Obstruction Disorders
- Galectins and Cancer Biology
- Infant Nutrition and Health
York St John University
2024
University of Messina
2012-2022
Teesside University
2021-2022
Istituto Ortopedico Gaetano Pini
2020
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2002-2018
Cystic Fibrosis Research Foundation
2018
University of Naples Federico II
1990-2017
Società Italiana di Fisica
2014
Policlinico Universitario di Catania
1987-2013
Martin University
2013
AbstractBackground: Recent epidemiologic studies in Europe using antigliadin (AGA) and anti-endomysium antibodies (AEA) for initial screening have shown that the overall prevalence of celiac disease (CD) is about 1:300. There are no comparable scientific data USA, where CD considered rare. The main aim this study was to determine increased AEA healthy blood donors USA. Methods: Sera from 2000 were screened IgG AGA IgA with an enzyme-linked immunosorbent assay test. All those levels,...
ABSTRACT Background and Objectives: Irritable bowel syndrome (IBS) is a common problem in pediatrics, for which no safe effective treatment available. Probiotics have shown some promising results adult studies, but positive study has been published on pediatric age. We aimed at investigating the efficacy of VSL#3 population children teenagers affected by IBS, randomized, double‐blind, placebo‐controlled, crossover conducted 7 gastroenterology divisions. Patients Methods: Children 4 to 18...
Acute bronchiolitis is the leading cause of lower respiratory tract infection and hospitalization in children less than 1 year age worldwide. It usually a mild disease, but some may develop severe symptoms, requiring hospital admission ventilatory support ICU. Infants with pre-existing risk factors (prematurity, bronchopulmonary dysplasia, congenital heart diseases immunodeficiency) be predisposed to form disease. Clinical diagnosis manly based on medical history physical examination...
The prevalence and natural history of gastroesophageal reflux in infants have been poorly documented. aim this study was to evaluate the infant regurgitation Italian children during first 2 years life.A detailed questionnaire, according Rome II criteria, completed by 59 primary care pediatricians assess consecutive patients seen their office over a 3-month period. A total 2642 aged 0 12 months were prospectively enrolled Follow-up performed at 6, 12, 18, 24 age.A 313 (12%; 147 girls)...
A dietary interview performed by expert personnel is the best method to check whether patients with coeliac disease follow a strict gluten-free diet (GFD). We previously developed score based on four fast and simple questions that can be administered even non-expert personnel. The aim of present study verify reliability our questionnaire in new cohort patients. has five-level score. From March 2008 January 2011, was 141 GFD, who were undergoing re-evaluation. obtained compared persistence...
Pediatric-onset Crohn disease is more aggressive than adult-onset disease, has high rates of resistance to existing drugs, and can lead permanent impairments. Few trials have evaluated new drugs for refractory in children.To determine whether thalidomide effective inducing remission pediatric disease.Multicenter, double-blind, placebo-controlled, randomized clinical trial 56 children with active despite immunosuppressive treatment, conducted August 2008-September 2012 6 tertiary care centers...
Bone turnover, collagen metabolism, and bone mineral status were investigated in 59 patients with cystic fibrosis 72 sex- age-matched control subjects. In all subjects serum concentrations of osteocalcin (OC), carboxy-terminal propeptide type I procollagen (PICP), amino-terminal III procollagen(PIIINP), cross-linked telopeptide collagen(ICTP), urinary values N-telopeptides (NTX), as well total body content (TBBM) measured. Higher ICTP (μg/L) NTX (bone equivalent/urinary creatinine...
Celiac disease (CD) and chronic urticaria (CU) are both sustained by immune mechanisms, but there so far few data on their clinical association. We performed a case–control study to determine the occurrence of CD in matched control children, assess relevance this Children adolescents were diagnosed have severe idiopathic presence hives for more than 6 wk poorly or not responsive oral antihistamines. Other known causes had be excluded. A group without was enrolled. In groups, searched...
Gene regulation is responsible for controlling numerous physiological functions and dynamically responding to environmental fluctuations. Reconstructing the human network of gene regulatory interactions thus paramount understanding cell functional organization across types, as well elucidating pathogenic processes identifying molecular drug targets. Although significant effort has been devoted towards this direction, existing computational methods mainly rely on expression levels, possibly...
Children allergic to cow's milk are fed a soy- or hydrolysed milk-based substitute. Neither can rule out sensitization risk. Previous studies have shown that rice is tolerated by animals and children with multiple food hypersensitivities.A prospective clinical assessment of tolerance rice-based formula was carried in milk. Patients methods One hundred (42 girls 58 boys, mean age 3.17+/-2.93 years, median 2.20, range 0.18-14.6 years) history immediate reactions confirmed at double-blind,...
Accuracy of intraepithelial lymphocytes counts for diagnosing mild enteropathy coeliac disease in absence villous atrophy can be limited by inappropriate controls included the studies.To determine diagnostic accuracy utilising lacking HLA disease-associated alleles.Intraepithelial counting at villus tip and per 100 enterocytes was performed haematoxylin eosin (H&E) CD3-stainings in: 29 cases (21 with potential 8 affected latent disease) representing patient population 14 noncoeliac...
Background and aims: the diagnosis of celiac disease requires small bowel biopsies to identify characteristic mucosal changes.The current biopsy practice among endoscopists for is in most part unknown.The aim this study was compare different diagnostic policies various centers their practice.Method: information from a total 931 confirmed patients retrospectively obtained nine European Middle Eastern countries.The number small-bowel duodenal bulb second duodenum compared centers.Results:...
Patients involved on coeliac disease (CD) have atypical symptoms and often remain undiagnosed. Specific oral manifestations are effective risk indicators of CD for this reason an early diagnosis with a consequent better prognosis can be performed by the dentist. There not researches analysing frequency these in potential patients. The aim study is to investigate hard soft tissue lesions ascertained children comparison healthy controls. 50 children, 21 patients, 54 controls were recruited...
High-throughput biological data, thanks to technological advances, have become cheaper collect, leading the availability of vast amounts omic data different types. In parallel, in silico reconstruction and modeling metabolic systems is now acknowledged as a key tool complement experimental on large scale. The integration these model- data-driven information therefore emerging new challenge biology, with no clear guidance how better take advantage inherent multisource multiomic nature types...
Monitoring cruises were carried out on four coastal transects of the southern Adriatic Sea over two years to investigate effects hydrodynamic regime environmental factors and phytoplankton species composition succession. The concentration nutrient salts is usually low except for winter months. Biomass levels (in terms chlorophyll a ) proved be very low, with values ranging between 0.05 1.25 μg Chl L −1 . Phytoplankton densities showed specific oligotrophic water varied in wide range from 9 ×...
Intestinal biopsy is required for a diagnosis of celiac disease (CD). The aim this study was to assess diagnostic accuracy transglutaminase antibodies (TGA) in comparison and association with that antiemdomysial (AEA), calculating the post-test odds having disease, verify whether some patients might avoid undergoing intestinal CD.A total 181 consecutive (131 < 18 yr), referred our clinic by primary care physicians suspect CD. Overall accuracy, negative predictive value, likelihood ratio (LR)...