A5059948207- Celiac Disease Research and Management
- Microscopic Colitis
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Gastrointestinal motility and disorders
- Gastrointestinal disorders and treatments
- Mobile Health and mHealth Applications
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Telemedicine and Telehealth Implementation
- Pancreatitis Pathology and Treatment
- Diabetes and associated disorders
- Gestational Trophoblastic Disease Studies
- Gastroesophageal reflux and treatments
- Probiotics and Fermented Foods
- Eosinophilic Esophagitis
- Infant Health and Development
- Healthcare Systems and Technology
- COVID-19 and healthcare impacts
- Drug Transport and Resistance Mechanisms
- Congenital gastrointestinal and neural anomalies
- Intestinal Malrotation and Obstruction Disorders
- Escherichia coli research studies
- Autoimmune and Inflammatory Disorders Research
- Neuroendocrine Tumor Research Advances
University of California, San Francisco
2024
Nationwide Children's Hospital
2023
UCSF Benioff Children's Hospital
2018-2022
University of Chicago
2005-2015
May Institute
2009
Manipal Teaching Hospital
2006
Columbia University
2006
Pediatrics and Genetics
2006
ABSTRACT Background and Objectives: Irritable bowel syndrome (IBS) is a common problem in pediatrics, for which no safe effective treatment available. Probiotics have shown some promising results adult studies, but positive study has been published on pediatric age. We aimed at investigating the efficacy of VSL#3 population children teenagers affected by IBS, randomized, double‐blind, placebo‐controlled, crossover conducted 7 gastroenterology divisions. Patients Methods: Children 4 to 18...
Celiac disease is an intestinal inflammatory disorder induced by dietary gluten in genetically susceptible individuals. The mechanisms underlying the massive expansion of interferon gamma-producing intraepithelial cytotoxic T lymphocytes (CTLs) and destruction epithelial cells lining small intestine celiac patients have remained elusive. We report oligoclonal expansions CTLs that exhibit a profound genetic reprogramming natural killer (NK) functions. These aberrantly expressed cytolytic NK...
IL-15 and NKG2D promote autoimmunity celiac disease by arming cytotoxic T lymphocytes (CTLs) to cause tissue destruction. However, the downstream signaling events underlying these functional properties remain unclear. Here, we identify cytosolic phospholipase A2 (cPLA2) as a central molecule in NKG2D-mediated cytolysis CTLs. Furthermore, report that induces, upon recognition of MIC+ target cells, release arachidonic acid (AA) CTLs inflammation association with killing. Interestingly, IL-15,...
GoalThe aim of this study was to investigate gene expression levels proteins involved in sphingosine-1-phosphate (S1P) metabolism and signaling a pediatric inflammatory bowel disease (IBD) patient population.
Telehealth (TH) broadly encompasses remote activities of clinical care (telemedicine), provider and patient education, general health services. The use synchronous video for TH first occurred in 1964 then catapulted to the forefront 2020 during coronavirus disease 2019 public emergency. Due sudden need increased utilization by nearly all providers at that time, became essential practice. However, its sustainable future is unclear part given best practices pediatric gastroenterology (GI),...
Objective The SI gene encodes the sucrase-isomaltase enzyme, a disaccharidase expressed in intestinal brush border. Hypomorphic variants cause recessive congenital deficiency (CSID) and related gastrointestinal (GI) symptoms. Among children presenting with chronic, idiopathic loose stools, we assessed prevalence of CSID-associated relative to general population GI symptom burden associated genotype within study population. Methods A prospective conducted at 18 centers enrolled 308...
With the coronavirus disease 2019 public health emergency (PHE), telehealth (TH) became essential for continued delivery of care. Members North American Society Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) formed Telehealth Gastrointestinal Care Now (TPGCN) working group rapidly organized a telemedicine webinar to provide education guidance. We aim describe development prospectively assess effectiveness this webinar-based educational intervention.NASPGHAN members who...
Patients with very early onset inflammatory bowel disease (VEO-IBD) have a higher incidence of monogenic compared to older age groups. Age, alone, is strong predictor for disease. We discuss case VEO-IBD in which the patient presented severe and refractory enteropathy, leading diagnosis CTLA-4 haploinsufficiency. Genetic workup showed de novo heterozygous deletions ICOS genes. This was unique, as did not other manifestations commonly present advocate routine genetic VEO-IBD, patients IBD...
Introduction: IEL expansion, malignant transformation and epithelial cell(IEC) killing are hallmarks of CD. Recent studies suggest the NK receptor, NKG2D, is crucial for IEC destruction, though it cannot mediate proliferation cytokine secretion. Linked with DAP10, an adaptor molecule a PI3-kinase binding motif, recruit ZAP70, kinase required transcriptional events. Normally, do not express NKG2C/DAP12, receptor complex capable recruiting ZAP70 inducing HLA-E, NKG2C ligand, non classical MHC...
Background: Celiac disease (CD) is an intestinal inflammatory induced in genetically susceptible people by gluten ingestion. A known mechanism the adaptive response to immunodominant peptides of α-gliadin recognized gliadin specific CD4+ T cells LP driving anti-tissue transglutaminase (TTG) antibody response. Mucosal damage mediated CD8+ intraepithelial lymphocytes recognizing innate epithelial stress ligands. The p31-49 peptide, unrecognized cells, triggers stress. Hypothesis: subset...