A5078062146- Celiac Disease Research and Management
- Immune Cell Function and Interaction
- Microscopic Colitis
- T-cell and B-cell Immunology
- Gut microbiota and health
- Galectins and Cancer Biology
- Atherosclerosis and Cardiovascular Diseases
- Digestive system and related health
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Cancer Cells and Metastasis
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Diabetes and associated disorders
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Oral microbiology and periodontitis research
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
Broad Institute
2021-2024
Massachusetts General Hospital
2022-2023
Harvard University
2023
University of Chicago
2013-2020
A nonpathogenic virus can promote inflammatory immunity to dietary antigens and may be linked the development of celiac disease.
Celiac disease (CeD), caused by immune reactions to cereal gluten, is treated with gluten -elimination diets. Within hours of exposure, either perorally or extraorally intradermal injection, patients experience gastrointestinal symptoms. To test whether exposure leads systemic cytokine production time -related symptoms, series multiplex measurements were obtained in CeD after challenge. Peptide injection elevated at least 15 plasma cytokines, IL-2, IL-8, and IL-10 being most prominent...
The semi-activation state of IELs is maintained by an altered cardiolipin makeup their mitochondrial membranes.
Effective tissue repair requires coordinated intercellular communication to sense damage, remodel the tissue, and restore function. Here, we dissected healing response in intestinal mucosa by mapping at single-cell resolution integrating with spatial transcriptomics. We demonstrated that a risk variant for Crohn’s disease, hepatocyte growth factor activator (HGFAC) Arg 509 His (R509H), disrupted damage-sensing pathway connecting coagulation cascade factors drive differentiation of...
The respective effects of tissue alarmins interleukin (IL)-15 and interferon beta (IFNβ), IL-21 produced by T cells on the reprogramming cytotoxic lymphocytes (CTLs) that cause destruction in celiac disease is poorly understood. Transcriptomic epigenetic profiling primary intestinal CTLs showed massive distinct temporal transcriptional changes response to alarmins, while impact was limited. Only anti-viral pathways were induced all three stimuli, albeit with differences dynamics strength....