A5005779388- Celiac Disease Research and Management
- Microscopic Colitis
- Viral Infections and Immunology Research
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Monoclonal and Polyclonal Antibodies Research
- Microbial Metabolites in Food Biotechnology
- Galectins and Cancer Biology
- Genetic factors in colorectal cancer
- Digestive system and related health
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Gastrointestinal motility and disorders
- Food Allergy and Anaphylaxis Research
- Diabetes Management and Research
- Viral gastroenteritis research and epidemiology
- Whipple's Disease and Interleukins
- Wheat and Barley Genetics and Pathology
- Transgenic Plants and Applications
- Immunodeficiency and Autoimmune Disorders
- Food composition and properties
- Gastrointestinal disorders and treatments
- Intestinal Malrotation and Obstruction Disorders
- Autoimmune Bullous Skin Diseases
- Calcium signaling and nucleotide metabolism
Murdoch Children's Research Institute
2015-2025
Walter and Eliza Hall Institute of Medical Research
2016-2025
The Royal Melbourne Hospital
2016-2025
The University of Melbourne
2016-2025
Royal Children's Hospital
2017-2019
Tampere University
2019
Universidad de Valladolid
2018
Instituto de Biomedicina y Genética Molecular de Valladolid
2018
Melbourne Health
2013
Monash University
2012
Celiac disease is a genetic condition that results in debilitating immune reaction the gut to antigens grain. The antigenic peptides recognized by T cells cause this are incompletely defined. Our understanding of epitopes pathogenic CD4+ based primarily on responses shown intestinal T-cells vitro hydrolysates or polypeptides gluten, causative antigen. A protease-resistant 33-amino acid peptide from wheat α-gliadin immunodominant antigen, but little known about spectrum cell rye and barley...
Cultivated oat (Avena sativa L.) is an allohexaploid (AACCDD, 2n = 6x 42) thought to have been domesticated more than 3,000 years ago while growing as a weed in wheat, emmer and barley fields Anatolia1,2. Oat has low carbon footprint, substantial health benefits the potential replace animal-based food products. However, lack of fully annotated reference genome hampered efforts deconvolute its complex evolutionary history functional gene dynamics. Here we present high-quality A. close...
We present a comprehensive analysis of variation in genes and gene expression allergens immunoresponsive proteins wheat.
Practical application of genomic-based risk stratification to clinical diagnosis is appealing yet performance varies widely depending on the disease and genomic score (GRS) method. Celiac (CD), a common immune-mediated illness, strongly genetically determined requires specific HLA haplotypes. testing can exclude but has low specificity, providing little information suitable for stratification. Using six European cohorts, we provide proof-of-concept that statistical learning approaches which...
Celiac disease (CeD), caused by immune reactions to cereal gluten, is treated with gluten -elimination diets. Within hours of exposure, either perorally or extraorally intradermal injection, patients experience gastrointestinal symptoms. To test whether exposure leads systemic cytokine production time -related symptoms, series multiplex measurements were obtained in CeD after challenge. Peptide injection elevated at least 15 plasma cytokines, IL-2, IL-8, and IL-10 being most prominent...
Changing perspectives on the natural history of celiac disease (CD), new serology and genetic tests, amended histological criteria for diagnosis cast doubt past prevalence estimates CD. We set out to establish a more accurate estimate CD using novel serogenetic approach. The human leukocyte antigen (HLA)-DQ genotype was determined in 356 patients with 'biopsy-confirmed' CD, two age-stratified, randomly selected community cohorts 1,390 women 1,158 men. Sera were screened CD-specific serology....
Monitoring adherence to a gluten-free diet is an important goal of coeliac disease management. Urine and stool gluten immunogenic peptide (GIP) assays provide objective readout ingestion, with the former favoured due its convenience acceptability. This study assessed GIP excretion after low-dose challenge designed mimic accidental exposure. A total 52 participants undertook randomised, double-blind (50–1000 mg) or placebo challenge. Stool urinary GIP, serology, dietary symptoms were...
Summary Background Brain fog is a subjective cognitive impairment commonly reported in coeliac disease. A standardised tool to define and assess it an important unmet need. Aims To develop patient‐informed brain disease support clinical care, research drug development. Methods pilot online study defined patient descriptors of fog. second evaluated the factor structure performance scale across two‐time points (‘Now’ ‘Past week’). One month later, participants were invited repeat with two...
Type 1 diabetes (T1D) is an autoimmune disease where T-cells mediate the destruction of insulin-producing beta-cells found within Islets Langerhans in pancreas. Currently, autoantibodies to beta-cell antigens are only tests available detect autoimmunity. T-cell responses antigens, which known cause T1D, can be measured research settings due complexity assays and large blood volumes required. Here we describe beta cell antigen specific assay - BASTA. BASTA a simple whole that human CD4+ by...
This cohort study examines whether there is a temporal association between SARS-CoV-2 infection and the development of islet autoimmunity among Australian children with first-degree relative type 1 diabetes.
Celiac disease is a chronic immune-mediated inflammatory disorder of the gut triggered by dietary gluten. Although effector T-cell response in patients with celiac has been well characterized, role regulatory T (Treg) cells loss tolerance to gluten remains poorly understood.We sought define whether have dysfunction or lack gluten-specific forkhead box protein 3 (FOXP3)+ Treg cells.Treated underwent oral wheat challenge stimulate recirculation cells. Peripheral blood was collected before and...
A gluten-free diet treats coeliac disease, but its efficacy depends on strict adherence. variety of patient factors may influence adherence have not been well described at a population level.To comprehensively assess the that in patients with disease.Patients disease completed an online survey comprising validated Celiac Dietary Adherence Test addition to data demographics, details diagnosis and management assessment knowledge, quality life psychological distress. Survey were analysed for...