A5040013370- Neonatal Respiratory Health Research
- Neonatal and Maternal Infections
- Respiratory viral infections research
- Infant Nutrition and Health
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Cystic Fibrosis Research Advances
- Infant Development and Preterm Care
- Tracheal and airway disorders
- Neonatal Health and Biochemistry
- COVID-19 Impact on Reproduction
- Infant Health and Development
- Retinopathy of Prematurity Studies
- Fungal Infections and Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Heart Disease Studies
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Viral gastroenteritis research and epidemiology
- Sepsis Diagnosis and Treatment
- Breastfeeding Practices and Influences
- COVID-19 and healthcare impacts
- Ultrasound in Clinical Applications
Ospedale degli Infermi
2019-2025
University of Turin
2005-2025
Ospedale Sant'Anna
2011-2024
Ospedale degli Infermi
2019-2023
ASL Roma
2023
Infant
2019-2020
AOL (United States)
2020
Pension Fund for Care and Well-Being
2019
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2015-2018
University of Liverpool
2018
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants, and a need exists for prevention RSV healthy infants. Nirsevimab monoclonal antibody with an extended half-life that being developed to protect infants entire season single intramuscular dose.
<h3>Context</h3>Sepsis is a common and severe complication in premature neonates, particularly those with very low birth weight (VLBW) (<1500 g). Whether lactoferrin, mammalian milk glycoprotein involved innate immune host defenses, can reduce the incidence of sepsis unknown. In animal models, probiotic Lactobacillus rhamnosus GG (LGG) enhances activity lactoferrin but has not been studied human infants.<h3>Objective</h3>To establish whether bovine (BLF), alone or combination LGG, reduces...
Invasive candida infections are a major cause of morbidity and mortality in preterm infants. We performed multicenter, randomized, double-blind, placebo-controlled trial fluconazole for the prevention fungal colonization infection very-low-birth-weight neonates.
Background. Colonization by Candida species is the most important predictor of development invasive fungal disease in preterm neonates, and enteric reservoir a major site colonization. We evaluated effectiveness an orally supplemented probiotic (Lactobacillus casei subspecies rhamnosus; Dicoflor [Dicofarm spa]; 6 × 109 cfu/day) prevention gastrointestinal colonization preterm, very low birth weight (i.e., <1500-g) neonates during their stay neonatal intensive care unit. Methods. Over...
OBJECTIVE. Colonization by Candida spp is a major risk factor for development of fungal sepsis, but little known about the variables associated with progression to invasive disease in already colonized neonates. We investigated such large number preterm neonates an NICU. SETTING. This study was conducted Department Neonatology and NICU at Sant'Anna Hospital Torino, Italy. DESIGN AND PATIENTS A database search clinical charts weekly surveillance cultures used identify all birth weights...
Acute bronchiolitis is the leading cause of lower respiratory tract infection and hospitalization in children less than 1 year age worldwide. It usually a mild disease, but some may develop severe symptoms, requiring hospital admission ventilatory support ICU. Infants with pre-existing risk factors (prematurity, bronchopulmonary dysplasia, congenital heart diseases immunodeficiency) be predisposed to form disease. Clinical diagnosis manly based on medical history physical examination...
Lactoferrin is a mammalian milk glycoprotein involved in innate immunity. Recent data show that bovine lactoferrin (bLF) prevents late-onset sepsis preterm very low birth weight (VLBW) neonates.This secondary analysis of from multicenter randomized controlled trial where VLBW neonates randomly received bLF (100 mg/day; group A1), + Lactobacillus rhamnosus GG (10(6) colony-forming units per day; A2), or placebo (group B) for 6 weeks. Here we analyze the incidence rates fungal colonization,...
Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality the safety of fluconazole are unknown.
Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care unit (NICU) may inform stewardship efforts.We conducted a one-day global point prevalence study all antimicrobials provided NICU infants. Demographic, clinical, and microbiologic data were obtained including level, census, birth weight, gestational/chronologic age, diagnoses, therapy (reason for use; length therapy), program (ASP), 30-day in-hospital mortality.On July 1, 2019, 26% (580/2,265;...
Respiratory syncytial virus (RSV) is a highly contagious seasonal and the leading cause of Lower Tract Infections (LRTI), including pneumonia bronchiolitis in children. RSV-related LRTI approximately 3 million hospitalizations 120,000 deaths annually among children <5 years age. The majority burden RSV occurs previously healthy infants. Only monoclonal antibody (mAb) has been approved against infections restricted group, leaving an urgent unmet need for large number potentially benefiting...