A5020523831- Celiac Disease Research and Management
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Digestive system and related health
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Alcohol Consumption and Health Effects
- Wheat and Barley Genetics and Pathology
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Food composition and properties
- Gastroesophageal reflux and treatments
- Food Allergy and Anaphylaxis Research
- Intestinal Malrotation and Obstruction Disorders
- Inflammatory Bowel Disease
- Viral Infections and Immunology Research
- Glycogen Storage Diseases and Myoclonus
- Long-Term Effects of COVID-19
- Infant Health and Development
- Microbial Metabolites in Food Biotechnology
- Cancer Immunotherapy and Biomarkers
- Substance Abuse Treatment and Outcomes
- Congenital gastrointestinal and neural anomalies
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
University of Ferrara
2018-2025
Ospedale Policlinico San Martino
2021
Medica (Italy)
2020
University of Bologna
2010-2020
Arcispedale Sant'Anna
2020
Policlinico S.Orsola-Malpighi
2010-2018
Zambon (Italy)
2018
To characterize the serological pattern of gluten sensitivity (GS) and to compare it with that found in celiac disease.GS has recently been identified as a new clinical entity included spectrum gluten-related disorders, but is still lacking diagnostic markers.Sera from 78 patients GS 80 disease were retrospectively assessed for immunoglobulin (Ig)G/IgA antigliadin antibodies (AGA), IgG deamidated gliadin peptide (DGP-AGA), IgA tissue transglutaminase (tTGA), endomysial (EmA).IgG AGA positive...
Wheat gluten and related proteins can trigger an autoimmune enteropathy, known as coeliac disease, in people with genetic susceptibility. However, some individuals experience a range of symptoms response to wheat ingestion, without the characteristic serological or histological evidence disease. The aetiology mechanism these are unknown, no biomarkers have been identified. We aimed determine if sensitivity absence disease is associated systemic immune activation that may be linked...
Celiac disease is a multiform, challenging condition characterized by extremely variable features. Our goal was to define clinical, serological and histopathological findings in large cohort of celiacs diagnosed single referral center.From January 1998 December 2012, 770 patients (599 females, median age 36 years, range 18-78 years) were as at St. Orsola-Malpighi Hospital (Bologna, Italy). The clinical phenotypes classified as: 1) classical (malabsorption syndrome); 2) non-classical...
Non-celiac gluten sensitivity is a syndrome characterized by gastrointestinal and extra-intestinal symptoms occurring in few hours/days after and/or other wheat protein ingestion rapidly improving exclusion of potential dietary triggers. There are no established laboratory markers for non-celiac sensitivity, although high prevalence first generation anti-gliadin antibodies IgG class has been reported this condition. This study was designed to characterize the effect gluten-free diet on...
An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's [CrD]. We explored clinico-pathological, molecular, prognostic features CD-associated SBC [CD-SBC] CrD-associated [CrD-SBC] comparison with sporadic [spo-SBC].A total 76 patients undergoing surgical resection for non-familial [26 CD-SBC, 25 CrD-SBC, spo-SBC] were retrospectively enrolled to investigate patients' survival histological molecular including microsatellite instability [MSI]...
Non-coeliac gluten sensitivity (NCGS) is characterised by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing foods, in absence coeliac disease (CD) wheat allergy. No biomarkers are available diagnose NCGS gold standard double-blind placebo-controlled challenge clinically impractical. The aim our work was investigate role serum zonulin as a diagnostic biomarker develop algorithm.In multicentre study, we enrolled 86 patients with either self-reported or...
Differential diagnosis of villous atrophy (VA) without coeliac antibodies in adults includes seronegative disease (CD) and chronic enteropathies unrelated to gluten, ie. non-coeliac (NCEs). There is currently no international consensus on the nomenclature diagnostic criteria for these enteropathies. In this work, a Delphi process was conducted address clinical uncertainty.An task force 13 gastroenterologists from six countries recruited at 16th International Coeliac Disease Symposium, Paris,...