A5033362809- Asthma and respiratory diseases
- Gastrointestinal motility and disorders
- Intestinal and Peritoneal Adhesions
- Allergic Rhinitis and Sensitization
- Congenital gastrointestinal and neural anomalies
- Immunodeficiency and Autoimmune Disorders
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- 3D Printing in Biomedical Research
- Food Allergy and Anaphylaxis Research
- Gut microbiota and health
- Olfactory and Sensory Function Studies
- Intestinal Malrotation and Obstruction Disorders
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Child Nutrition and Feeding Issues
- Liver physiology and pathology
- Chemical Reactions and Isotopes
- Electrospun Nanofibers in Biomedical Applications
- Pneumothorax, Barotrauma, Emphysema
- Amino Acid Enzymes and Metabolism
- Pleural and Pulmonary Diseases
- Gastrointestinal disorders and treatments
Sapienza University of Rome
2020-2025
University of Bologna
2011-2020
Policlinico Umberto I
2020
Policlinico S.Orsola-Malpighi
2011-2015
Istituto Ortopedico Rizzoli
1998
Biocom
1997
University of Genoa
1985
Background Acute administration of the antitumoral drug cisplatin can induce nausea/emesis and diarrhea. The long-term effects on gastrointestinal motility, particularly after repeated administration, are not well known. Because is highly neurotoxic, myenteric neurons be affected. Our aim was to study prolonged in a rat model, focusing motor function neurons. Methods Rats received saline or (1 3 mg kg−1, i.p.) once weekly for 5 weeks. One week treatment, both upper transit colonic activity...
Abstract Resveratrol is a nonflavonoid polyphenolic compound with chemical structure consisting of two aromatic rings linked by methylene bridge. It exists in primary isomers and has broad range desirable biological activities, including antioxidant, anti‐inflammatory, antidiabetic, cardioprotective, antitumor activities. Some antioxidant properties resveratrol are known certainty, such as its potential to positively impact cardiovascular health, inflammation, the metabolism. On other hand,...
Anosmia is a well described symptom of Corona Virus Disease 2019. Several respiratory viruses are able to cause post-viral olfactory dysfunction, suggesting sensorineural damage. Since the bulb considered an immunological organ contributing prevent invasion viruses, it couldhave role in host defence. . The inflammatory products locally released COVID-19, leading local damage and causing loss, simultaneously may interfere with viral spread into central nervous system. In this context,...
Abstract Background Angioedema is a condition marked by sudden, intense swelling of the subcutaneous and submucosal tissues, typically associated with hypersensitivity reactions, genetic mutations, or reactions to medications. It can also result from contact allergens such as nickel, leading dermatitis. Case presentation : A 12-year-old girl presented at our Pediatric Immunology Allergology service recurrent labial angioedema for over year, linked consumption legumes tomatoes, following use...
Background: Emerging evidence suggests that nutraceuticals, alongside standard therapy, may benefit children with allergic rhinitis (AR). This study aimed to compare the efficacy of Quertal® (Neopharmed Gentili S.p.A., Milano, Italy), a nutraceutical supplement based on Perilla frutescens, Quercetin, and vitamin D3, combined antihistamines per os versus alone, in improving AR symptoms considering respiratory functional laboratory biomarkers pediatric age. Materials Method: included 100...
Background: Allergy to Alternaria alternata (Alt a), although often underdiagnosed, is a significant global health issue. In the allergen immunotherapy (AIT) field, novel therapeutic strategies are emerging, particularly with advent of polymerized allergoids. This study aims evaluate efficacy subcutaneous (SCIT) based on these innovative molecules in children respiratory allergies, assessing clinical and functional parameters. Methods: We enrolled 42 patients aged between 6 16 years, all...
The pathogenetic mechanisms underlying gastrointestinal dysmotility in diabetic patients remain poorly understood, although enteric neuropathy, damage to interstitial cells of Cajal (ICC) and smooth muscle cell injury are believed play a role. aim this study was investigate the morphological functional changes intestinal RIP-I/hIFNβ transgenic mice treated with multiple very low doses streptozotocin (20 mg/kg, i.p., 5 days). Compared vehicle-treated mice, streptozotocin-treated animals...
Abstract Background Intestinal manometry is the current standard for direct evaluation of small bowel dysmotility. Patients with abnormal motility can either be diagnosed pseudo‐obstruction when there are radiological findings mimicking mechanical intestinal obstruction or enteric dysmotility these absent. The aim present study was to prospectively compare manometric abnormalities histopathological in full‐thickness biopsies patients severe disorders. Methods We investigated 38 and a...
Abstract Background Gastrointestinal (GI) and extra‐GI symptoms/manifestations represent key clinical features of patients with non‐celiac gluten/wheat sensitivity (NCG/WS). This study aimed to investigate neuro‐immune (focusing on mast cells, MCs) interactions in the duodenal submucosa NCG/WS. Methods Submucosal whole mounts from biopsies 34 self‐reported NCG/WS, 28 celiac disease (CD), 13 functional dyspepsia (FD), 24 healthy controls (HC) were analyzed by immunohistochemistry....
Background: During the lockdown period caused by SARS-CoV-2 pandemic, we monitored via online survey trend of allergic symptoms and therapeutic compliance in patients followed at our center. Material methods: In June 2020, selected children Allergy Immunology Service Umberto I Hospital, aged between 6 16 years old, diagnosed with asthma and/or rhinitis sensitized to grass pollen or dust mite. We sent an email 12 multiple-choice questions investigating several areas: type disease...
Abstract Food supplements are defined as foodstuffs the purpose of which is to supplement normal diet and concentrated sources nutrients or other substances with a nutritional physiological effect, often referred nutraceuticals, may exert benefit human body. Their use increasing worldwide, including Europe in Italy. However, some doctors skeptical about their effectiveness safety. This reluctance depend on poor knowledge mechanisms action clinical evidence literature. The Italian Society...
Gastrointestinal (GI) symptoms can originate from severe dysmotility due to enteric neuropathies. Current methods used demonstrate neuropathies are based mainly on classic qualitative histopathological/immunohistochemical evaluation. This study was designed identify an objective morphometric method for paraffin-embedded tissue samples quantify the interganglionic distance between neighboring myenteric ganglia immunoreactive neuron-specific enolase, as well number of and submucosal neuronal...
Silicones for dental impression largely are used to record the geometry of hard and soft tissues. They considered be medical devices, assessment cytotoxicity is a necessary step in evaluation their biocompatibility. Extracts six addition-type condensation-type silicones have been tested with L929 cells according ISO 10993—Part 5 standard. The was evaluated by three different methods: neutral red uptake, propidium iodide (PI) staining, amido black staining. According selected specific assay,...