A5011272669- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Infant Health and Development
- Digestive system and related health
- Celiac Disease Research and Management
- Whipple's Disease and Interleukins
- Pathogenesis and Treatment of Hiccups
- Eating Disorders and Behaviors
- Microscopic Colitis
- Eosinophilic Esophagitis
- Child Nutrition and Feeding Issues
- Complementary and Alternative Medicine Studies
- Biochemical Analysis and Sensing Techniques
- Animal Nutrition and Physiology
- Congenital gastrointestinal and neural anomalies
- Hereditary Neurological Disorders
- Regulation of Appetite and Obesity
- Intestinal and Peritoneal Adhesions
- Endometrial and Cervical Cancer Treatments
- Respiratory and Cough-Related Research
- Metabolism and Genetic Disorders
- Acupuncture Treatment Research Studies
- Dysphagia Assessment and Management
KU Leuven
2018-2025
Universitair Ziekenhuis Leuven
2024
Centre Hospitalier Universitaire Brugmann
2006
OBJECTIVES: Prokinetics are considered the preferred treatment option for gastroparesis, but evidence of their efficacy is scarce. Prucalopride, a selective 5-hydroxytryptamine 4 receptor agonist used in constipation, able to enhance gastric emptying rate. In double-blind, randomized, placebo-controlled crossover study, we evaluated prucalopride improve rate and symptoms patients with gastroparesis. METHODS: Thirty-four gastroparesis (28 idiopathic, 7 men, mean age 42 ± 13 years) were...
Background In Europe, IBS is commonly treated with musculotropic spasmolytics (eg, otilonium bromide, OB). tertiary care, a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet provides significant improvement. Yet, dietary treatment remains to be explored in primary care. We evaluated the effect of smartphone FODMAP-lowering application versus OB on symptoms care IBS. Methods patients, recruited by physicians, were randomised 8 weeks (40 mg three times...
Abstract Background/Objectives The global epidemiology of gastroparesis is unknown. European UEG and Society for Neurogastroenterology motility consensus defines Gastroparesis as a condition characterized by delayed gastric emptying in the absence mechanical obstruction, with symptom pattern nausea and/or vomiting overlapping postprandial distress syndrome (PDS). Real‐world evidence this gastroparesis‐like crucial step understanding gastroparesis. Methods In Rome Foundation Global...
The symptom-based diagnostic criteria for irritable bowel syndrome (IBS) have recently been revised in the Rome IV consensus. On other hand, with rising public awareness of IBS, self-diagnosis and self-management is also increasing. We compared prevalence impact IV-based IBS vs self-diagnosed general population.An internet panel filled out an online survey on symptoms their health care utilization daily activities.A representative 1012 individuals completed survey. Bowel were present 68.6%...
Background: Disorders of gut–brain interaction (DGBIs) have a complex pathophysiology that is often characterized by relationship between food ingestion and triggering symptoms. Understanding the underlying mechanisms role nutrients as therapeutic target are rapidly evolving. Aims methods: We performed narrative review literature using following keywords, their acronyms, associations: nutrients, disorders interaction; functional dyspepsia; malabsorption; irritable bowel syndrome; diarrhea;...
Summary Background The European consensus defined gastroparesis as a condition characterised by delayed gastric emptying (GE) in the absence of mechanical obstruction, with symptom pattern predominant nausea and/or vomiting and overlapping postprandial distress syndrome (PDS). distinction between patients those functional dyspepsia (FD), another gastrointestinal PDS or epigastric pain symptoms, is ongoing. Aim To investigate extent that patterns may differentiate from FD. Methods This...
Background: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by recurrent abdominal pain related to defecation and/or associated change in habits. According the stool type, four different IBS subtypes can be recognized, constipation predominant (IBS-C), diarrhea (IBS-D), mixed (IBS-M), and undefined (IBS-U). Patients report that their symptoms are exacerbated food. Thus, it important find nutritional approach could effective reducing symptoms. Objective:...
<title>Abstract</title> Background The role of low-grade-inflammation in Irritable Bowel Syndrome (IBS) a common disorder gut-brain interaction is unclear. Association with symptom severity, as well effects first line treatments are understudied. In large cohort primary care IBS patients (DOMINO trial), FODMAP-lowering diet application was superior improving symptoms compared to standard medical therapy (otilonium bromide, OB). We investigated the level pro-inflammatory markers this and its...
Introduction: In functional dyspepsia, increased gut permeability, low-grade inflammation and altered sensorimotor function have been reported. Both stress corticotropin-release hormone(CRH) shown to increase small bowel permeability in a mast-cell dependent fashion. Moreover, eosinophil-derived CRH has implicated activation. The aim of this study was evaluate whether administration alters duodenal immune activation healthy volunteers(HVs). Methods: An intravenous bolus 100μg or placebo...
Abstract Background Gastrointestinal (GI) and extra‐GI symptoms/manifestations represent key clinical features of patients with non‐celiac gluten/wheat sensitivity (NCG/WS). This study aimed to investigate neuro‐immune (focusing on mast cells, MCs) interactions in the duodenal submucosa NCG/WS. Methods Submucosal whole mounts from biopsies 34 self‐reported NCG/WS, 28 celiac disease (CD), 13 functional dyspepsia (FD), 24 healthy controls (HC) were analyzed by immunohistochemistry....
In healthy volunteers, peripheral corticotropin-releasing hormone (CRH) infusion accelerates gastric-emptying rate and increases postprandial gastric response, accompanied by a rise in symptoms, but does not alter sensitivity or meal-induced accommodation. These findings underscore significant link between stress dyspeptic with CRH playing pivotal role mediating these effects.
The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact the healthcare system and services. In acute phase, presence of SARS-CoV-2 virus in aerodigestive tract limited activities gastroenterology clinic procedures to emergencies only. Motility function testing was interrupted as we enter recovery restarting these requires safety-focused approach with adequate infection prevention for patients professionals.We summarized knowledge risk spread motility functional...