A5001279619- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Helicobacter pylori-related gastroenterology studies
- Infant Health and Development
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Asthma and respiratory diseases
KU Leuven
2023-2025
Introduction: In functional dyspepsia, increased gut permeability, low-grade inflammation and altered sensorimotor function have been reported. Both stress corticotropin-release hormone(CRH) shown to increase small bowel permeability in a mast-cell dependent fashion. Moreover, eosinophil-derived CRH has implicated activation. The aim of this study was evaluate whether administration alters duodenal immune activation healthy volunteers(HVs). Methods: An intravenous bolus 100μg or placebo...
In healthy volunteers, peripheral corticotropin-releasing hormone (CRH) infusion accelerates gastric-emptying rate and increases postprandial gastric response, accompanied by a rise in symptoms, but does not alter sensitivity or meal-induced accommodation. These findings underscore significant link between stress dyspeptic with CRH playing pivotal role mediating these effects.