A5045511857- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Behavioral Health and Interventions
- Mobile Health and mHealth Applications
- Respiratory viral infections research
- Olfactory and Sensory Function Studies
- Indoor Air Quality and Microbial Exposure
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Horticultural and Viticultural Research
- Diverse academic and cultural studies
- Telemedicine and Telehealth Implementation
- Psychology of Moral and Emotional Judgment
- Plant Reproductive Biology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Celiac Disease Research and Management
- Drug-Induced Adverse Reactions
- Advanced Chemical Sensor Technologies
- Leech Biology and Applications
- Eosinophilic Esophagitis
- Social Media in Health Education
Ospedale Sandro Pertini
2016-2024
Charité - Universitätsmedizin Berlin
2015
University of Milan
2015
Policlinico Tor Vergata
2015
University of Verona
2015
Ospedale Maggiore
2015
University of Parma
2015
Fatebenefratelli Hospital
2015
Sapienza University of Rome
2011
Pollen allergy poses a significant health and economic burden in Europe. Disease patterns are relatively homogeneous within Central Northern European countries. However, no study broadly assessed the features of seasonal allergic rhinitis (SAR) across different Southern countries with standardized approach.
Pollen-food syndrome (PFS) is heterogeneous with regard to triggers, severity, natural history, comorbidities, and response treatment. Our study aimed classify different endotypes of PFS based on IgE sensitization panallergens.We examined 1271 Italian children (age 4-18 years) seasonal allergic rhinoconjunctivitis (SAR). Foods triggering were acquired by questionnaire. Skin prick tests performed commercial pollen extracts. panallergens Phl p 12 (profilin), Bet v 1 (PR-10), Pru 3 (nsLTP)...
Little is known about the prevalence and clinical relevance of hypersensitivity to plant panallergen profilin in children.The present study aimed investigate prevalence, risk factors sensitization a large cohort Italian children different ages living geographic areas.Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited three main areas Italy were studied. SPT carried out commercial extracts purified date palm profilin. IgE specific for allergenic molecules, Phl p 12...
Grass pollen-related seasonal allergic rhinoconjunctivitis (SARg) is clinically heterogeneous in severity, comorbidities, and response to treatment. The component-resolved diagnostics disclosed also a high heterogeneity at molecular level. Our study aimed analyzing the characteristics of IgE sensitization Phleum pratense molecules investigating diagnostic relevance such childhood.We examined 1120 children (age 4-18 years) with SARg. Standardized questionnaires on atopy were acquired through...
Background Complete diagnosis and therapy of seasonal allergic rhinoconjunctivitis require evidence that exposure to the sensitizing pollen triggers symptoms. Electronic clinical diaries, by recording disease severity scores exposure, can demonstrate this association. However, patients who spontaneously download an e-diary app show very low adherence their recording. Objective The objective our study was assess with rhinitis symptom via explicitly prescribed allergist within a blended care...
Abstract Background IgE antibodies to cross‐reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes allergen‐specific tests in vitro. Their prevalence and levels have been so far cross‐sectionally examined among adult allergic patients much less is known about their origins relevance childhood. Methods We CCD with cross‐sectional approach 1263 Italian pollen children (Panallergen Paediatrics, PAN‐PED), as well longitudinal...
Summary Background The identification of the primary sensitizing pollen is difficult in Southern European patients with Seasonal Allergic Rhinitis (SAR) if sensitized to various sources overlapping seasonality. A more precise diagnosis obtained by IgE assays allergen molecules, currently available as singleplex or microarrays. Objectives To test analytical performance a multi‐parameter immunoblot molecular “Pollen Test” specifically designed antibodies extracts and molecules clinically...
Abstract Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This especially relevant in geographic areas with broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities differences PFAS nine European centers identify associated characteristics unique markers PFAS. Methods As part the @IT.2020 Multicenter Study, 815 patients seasonal allergic...
Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and phenotypes have been thoroughly examined several cross-sectional studies. By contrast, only few studies evolution patient cohorts. We investigated predictive biomarkers of large cohort children with SAR.During 2015-2017 (follow-up), we re-examined 401 patients from those enrolled 2009-2011 (baseline) by the "Panallergens Pediatrics" study, multicenter...
Abstract Background Allergen immunotherapy (AIT) is the only disease‐modifying treatment in patients with seasonal allergic rhinoconjunctivitis (SAR). Its efficacy depends on precise identification of triggering allergen. However, diagnostics based retrospective clinical history and sensitization to whole extracts (SWE) often leads equivocal results. Objectives To assess usability impact a recently established algorithm for decision support system (@IT2020‐CDSS) SAR its diagnostic steps...
The adequate definition of pollen seasons is essential to facilitate a correct diagnosis, treatment choice, and outcome assessment in patients with seasonal allergic rhinitis. A position paper by the European Academy Allergy Clinical Immunology (EAACI) proposed season definitions for Northern Middle Europe.To test EAACI six Mediterranean cities seven taxa.As part @IT.2020 multi-center study, counts Poaceae, Oleaceae, Fagales, Cupressaceae, Urticaceae (Parietaria spp.), Compositae (Ambrosia...
The measurement of specific IgE to allergenic extracts and molecules in patients with allergic rhinitis (AR) is crucial for a precise diagnosis further immunotherapy. Companies providing vitro diagnostic methods allergology continuously strive the optimization modernization such methods. A new generation automated allergy tests based on chemiluminescence detection paramagnetic microparticles now available, possible advantages sample volume, cost-effectiveness avoidance sample-related...
There is growing interest both in testing IgE nasal secretions (NS) and molecular diagnosis of seasonal allergic rhinitis (SAR). Yet, the reliability detection with newest assays has never been assessed a large cohort pollen patients.To investigate microarray technology compare repertoires specific (sIgE) antibodies NS sera population children adults SAR.Nasal were collected an absorbent device (Merocel 2000® , Medtronic) minimal dilution procedure from 90 71 SAR. Total (tIgE) (ImmunoCAP,...
Abstract Background Patient‐generated symptom and medication scores are essential for diagnostic therapeutic decisions in seasonal allergic rhinitis (SAR). Previous studies have shown solid consistencies between different at population level real‐life data trials. For clinicians, the evaluation of individual quality over time is to decide whether rely on these clinical decision‐making. Objective To analyze consistency (SS) (SMSs) two study cohorts with characteristics explore patient...
Background: Poor asthma control can lead to exercise-induced bronchoconstriction (EIB), but the relationship between subjective disease and EIB is unclear. No studies have compared test (ACT) scores of children with those their parents regarding EIB. We assessed whether ACT predict occurrence in two age groups. also evaluated objective measures as explanatory variables for airway response exercise. Methods: Patients (71 aged <12 years, 93 ≥12 years) completed an questionnaire separately....
Abstract In the last few years, we have witnessed an important development in medical field of both Mobile Health, such as use mobile communication devices, and other telemedicine tools general, order to support surveillance diseases from moment first diagnosis therapeutic follow‐up. Long before COVID‐19, some authors had analyzed various possible evidence‐based scenarios indicated how could prove be extremely useful epidemic situations, especially for management chronic patients,...
Nasal provocation testing (NPT) is a reference methodology to identify the culprit allergen in patients with allergic rhinitis. Selecting right for NPT particularly difficult poly-sensitized seasonal rhinitis (SAR). Predictors of outcomes may facilitate proper use this test or even substitute it.To predictors grass pollen outcome from an array clinical data, e-diary outcomes, and allergy results pediatric SAR.Poly-sensitized, SAR allergy, participating @IT.2020 pilot project Rome Pordenone...