A5030052278- Hepatitis C virus research
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- Colorectal Cancer Treatments and Studies
- Renal Transplantation Outcomes and Treatments
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Genetic and Kidney Cyst Diseases
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Renal Diseases and Glomerulopathies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Research and Treatments
- Systemic Lupus Erythematosus Research
- Cancer Immunotherapy and Biomarkers
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Renal and related cancers
- Erythropoietin and Anemia Treatment
University of Insubria
2006-2023
Ospedale Maggiore
2007-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2007-2022
University of Milan
2009-2016
Universidade Federal de São Carlos
2010
Alessandro Manzoni Hospital
2007
Harvard University
2007
Westpfalz Klinikum
2007
Onze Lieve Vrouwziekenhuis Hospital
2007
An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's [CrD]. We explored clinico-pathological, molecular, prognostic features CD-associated SBC [CD-SBC] CrD-associated [CrD-SBC] comparison with sporadic [spo-SBC].A total 76 patients undergoing surgical resection for non-familial [26 CD-SBC, 25 CrD-SBC, spo-SBC] were retrospectively enrolled to investigate patients' survival histological molecular including microsatellite instability [MSI]...
Different risk factors are suspected to be involved in malignant transformation of sinonasal papillomas and include HPV infection, tobacco smoking, occupational exposure, EGFR/KRAS mutations DNA methylation alterations. In our study, 25 inverted (ISPs), 5 oncocytic (OSP) 35 squamous cell carcinomas (SCCs) from 54 patients were genotyped for 10 genes EGFR signalling. HPV-DNA detection was performed by in-situ hybridisation LINE-1 quantitatively determined bisulphite-pyrosequencing. High-risk...
Background: Routine testing of baseline EGFR T790M mutation may have important clinical impact but many discordant data been reported regarding the diagnostic, prognostic and predictive role this marker. In study we aimed to assess frequency in 164 untreated EGFR-mutated NSCLCs using methods with different sensitivity as well analyze relationship between status, patient's clinicopathologic features tyrosine kinase inhibitors (TKI) treatment outcomes. Methods: We compared diagnostic...
Abstract Purpose: The methylation status of hMLH1, CDKN2A, and MGMT was investigated in a panel synchronous cancers the ovary endometrium, fulfilling clinicopathologic criteria for independent primary tumors to define possible role epigenetic mechanisms development these cancers. Experimental Design: Bisulfite-converted DNA from 31 (13 endometrial 18 ovarian carcinomas) matched normal tissue 13 patients analyzed by methylation-specific PCR assay at CpG-rich 5′ regions all three genes. In...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We analysed PKD1 and PKD2, in a large cohort of 440 unrelated Italian patients with ADPKD 203 relatives by direct sequencing MLPA. Molecular detailed phenotypic data have been collected submitted to PKD1/PKD2 LOVD database. This first retrospective study patients, describing 701 variants, 249 (35.5%) already associated 452 (64.5%) novel. According criteria adopted, overall detection rate was...
Abstract Purpose: The molecular pathogenesis of gastroenteropancreatic endocrine tumors (ETs) is still largely unknown. purpose this work was a characterization 38 ETs with respect to the primary site and morphofunctional profile, pointing out useful diagnostic or prognostic markers. Experimental Design: Twenty-four well-differentiated carcinomas (WDET/Cs; 11 pancreatic, 3 gastric, 10 intestinal) 14 poorly differentiated (1 6 7 colorectal) were microallelotyped using polymorphic...
Histidine decarboxylase (HDC) and vesicular monoamine transporter 2 (v-MAT2) are involved in the biosynthesis storage of histamine. DOPA (DDC) is a variety amines shares high degree homology with HDC. HDC v-MAT2 immunoreactivities (IR) have recently been detected well-differentiated neuroendocrine tumors (WDNETs) poorly differentiated carcinomas (PDNECs) various sites proposed as general endocrine markers. We evaluated IR series 117 WDNETs PDNECs from different sites. Western blotting...
Object: The treatment of choice in glioblastoma (GBM) is the maximal surgical extent resection (EOR) followed by adjuvant chemo-radiotherapy. Furthermore, methylguanine-DNA methyltransferase (MGMT) promoter methylation associated with prolonged overall survival (OS) and progression free (PFS). objective present study correlate biomolecular aspects relation EOR. Materials methods: We analyzed a series 116 patients IDH-1 wild type GBM different EOR (Gross Total Resection-GTR-, Partial...
This study selected a series of 136 MSI-H (microsatellite instability at high frequency) gastric, colorectal, and endometrial carcinomas combining immunohistochemical analysis for hMLH1 or hMSH2 gene products microsatellite study. The clinico-pathological profile all tumours was correlated with the overall rates coding non-coding repeats, in order to clarify role mutation timing seven target genes (TGFbetaRII, IGFIIR, BAX, hMSH3, hMSH6, CHK1, BRCA2) progression an neoplasm. Regardless...
This work has evaluated the potential superiority of a morphomolecular classification based on combination clinicopathologic and molecular features colorectal cancers. A cohort 126 carcinomas was investigated by unsupervised hierarchical clustering analysis to combine 13 routinely assessed all five markers recently suggested Jass' distinguish four subtypes sporadic carcinomas. Survival Cox proportional hazards model. clear separation into three prognostically significant groups identified:...
Aims: (1) To validate a quantitative real time methylation specific PCR assay (MethyLight) for the detection of O 6 -methylguanine-DNA methyltransferase (MGMT) gene status (MS) in diffuse large B-cell lymphoma (DLBCL). (2) determine immunohistochemical (IHC) expression MGMT protein and correlate it with MS. Both IHC MethyLight results were compared patient’s outcome. Methods: 71 patients primary nodal DLBCL studied. immunoreactivity was detected using monoclonal antibody. The MS analysed...