A5041885427- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Long-Term Effects of COVID-19
- Radiomics and Machine Learning in Medical Imaging
- Testicular diseases and treatments
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cancer and Skin Lesions
- Eosinophilic Disorders and Syndromes
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- PARP inhibition in cancer therapy
- Lipoproteins and Cardiovascular Health
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Medical Imaging Techniques and Applications
- COVID-19 Clinical Research Studies
IRCCS Ospedale San Raffaele
2023-2025
Vita-Salute San Raffaele University
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2023
Ospedale di Circolo e Fondazione Macchi
2017-2021
Aziende Socio Sanitarie Territoriale dei Sette Laghi
2019-2021
Azienda Socio Sanitaria Territoriale Lariana
2020
Abstract Background Patients with solid or hematological tumors neurological and immune-inflammatory disorders are potentially fragile subjects at increased risk of experiencing severe coronavirus disease 2019 an inadequate response to acute respiratory syndrome 2 (SARS-CoV-2) vaccination. Methods We designed a prospective Italian multicenter study assess humoral T-cell responses SARS-CoV-2 vaccination in patients (n = 378) (ST), malignancies (HM), (ND), immunorheumatological diseases (ID)....
Background: Routine testing of baseline EGFR T790M mutation may have important clinical impact but many discordant data been reported regarding the diagnostic, prognostic and predictive role this marker. In study we aimed to assess frequency in 164 untreated EGFR-mutated NSCLCs using methods with different sensitivity as well analyze relationship between status, patient's clinicopathologic features tyrosine kinase inhibitors (TKI) treatment outcomes. Methods: We compared diagnostic...
The ability to identify the broadest range of targetable gene fusions is crucial facilitate personalized therapy selection for advanced lung adenocarcinoma (LuADs) patients harboring receptor tyrosine kinase (RTK) genomic alterations. In order evaluate most effective testing approach LuAD fusion detection, we analyzed 210 NSCLC selected clinical samples, comparing in situ (Fluorescence Situ Hybridization, FISH, and ImmunoHistoChemistry, IHC) molecular (targeted RNA Next-Generation...
Real-world data is an important complement to randomized controlled trials and can be used assess whether study results translate well routine clinical practice groups of patients that are often excluded from trials. The aim this disease natural history care quality assessment (DINASTY) describe treatments, outcomes for with metastatic non-small cell lung cancer using real-world data. a retrospective observational multicenter conducted within DIGICORE, non-profit European Economic Interest...
Hypereosinophilic syndrome (HES) represents a group of blood disorders characterized by an absolute eosinophil count (AEC) > 1.5 × 103/μl in the peripheral blood, which eventually extravasate and cause organ damage. It can be primary or secondary to infections tumors. The infiltration eosinophils tissue organs is associated with different and, some cases, life-threatening manifestations. Albeit pathogenesis HES patients solid tumo\rs not yet clarified; recently, has also been described as...
<h3>Background</h3> Retrospective clinical data on melanoma and non-small cell lung cancers have shown that patients taking statins before the onset of checkpoint inhibitors (CPI), a better progression free survival (PFS) overall (OS). Starting from this evidence, we investigated efficacy biologic mechanisms simvastatin plus anti-PD1 in melanoma-baring mice. <h3>Methods</h3> We analyzed PFS OS our cohort metastatic performed vivo experiments to compare effect simvastatin, or combination...
Approximately 50% of melanomas are characterized by BRAF mutation (V600E in 90% cases), that predicts more aggressive behaviour. This is the target dabrafenib, an anti-BRAF tyrosine-kinase inhibitor (TKI), together with trametinib, anti-MEK TKI, approved for first-line treatment metastatic melanoma due to significant benefit overall and progression-free survival. Most common treatment-related adverse events pyrexia, chills, fatigue, rash, nausea, vomiting, diarrhoea. case report aims present...
International guidelines support performing baseline positron emission tomography (PET) in lymphoma. Metabolic tumor volume (MTV) measurement has been proposed as a good of disease burden. We investigated if MTV at PET can be predictive complete response (CR) to first line standard chemotherapy diffuse large B-cell lymphoma (DLBCL) and follicular (FL) grade IIIb.We retrospectively analyzed data on 54 consecutive patients with DLBCL FL IIIb treated our institution. Dedicated software...
Testicular cancer is relatively uncommon, but at the same time, it most common solid tumor in men between ages of 20 and 34 years. Seminoma represents frequently encountered germ cell tumors. Because orchiectomy usually performed before chemotherapy, little known about effect systemic chemotherapy on primary testicular Furthermore, testis has always been considered a sanctuary site, an immune-privileged site which inadequate exposure to may occur. We report case young patient with advanced...