A5060732049- Helicobacter pylori-related gastroenterology studies
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Personality Disorders and Psychopathology
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- Regional Development and Policy
- Eosinophilic Esophagitis
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Genomics and Diagnostics
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Psychotherapy Techniques and Applications
- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- Italy: Economic History and Contemporary Issues
- Mental Health and Psychiatry
- Celiac Disease Research and Management
- COVID-19 Clinical Research Studies
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Ovarian cancer diagnosis and treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
Istituti di Ricovero e Cura a Carattere Scientifico
2011-2023
Sapienza University of Rome
1991-2022
Universidade Vila Velha
2013-2022
Istituti Fisioterapici Ospitalieri
2005-2021
Centro di Terapia Metacognitiva Interpersonale
2006-2021
Neuroscience Institute
2020
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020
University of Turin
2020
Bank of Italy
2013-2019
Istituto di Sessuologia Clinica
1996-2019
Literature data suggests that age, gender and body mass index (BMI) could be associated with difference in immune responses to vaccines. The first goal of the study was analyze antibody titre seven days after second dose BNT162b2 vaccine a group 248 healthcare workers (HCWs). how changes correlation gender, BMI hypertension.An immunogenicity evaluation carried out among HCWs vaccinated at Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy. All were asked by Italian national campaign...
ABSTRACT Background The first goal of the study was to analyse antibody titre 7 days after second dose BNT162b2 vaccine in a group 248 healthcare workers (HCW). how changes correlation with age, gender and BMI. Methods Participants were assigned receive priming at baseline booster day 21. Blood nasopharyngeal swabs collected vaccine. Findings HWCs analysed, 158 women (63.7%) 90 men (36.3%). After vaccine, 99.5% participants developed humoral immune response. geometric mean concentration...
Prostate cancer (PCa) is the most common male in Europe and US. The early diagnosis relies on prostate specific antigen (PSA) serum test, even if it showed clear limits. Among new tests currently under study, one of promising gene 3 (PCA3), a non-coding mRNA whose level increases up to 100 times PCa tissues when compared normal tissues. With present study we contribute validation clinical utility PCA3 test evaluation its prognostic potential.
Altered circulating cell-free DNA (cfDNA) levels are related to cancer development and aggressiveness. Up now, very few studies have been performed for evaluating cfDNA content in endometrial (EC).First, we measured release blood serum of EC patients collected before surgery the beginning any treatment by SYBR Gold assay correlated it with tumor We also assessed relative mitochondrial (cfmtDNA) qRT-PCR. Next, BMI, age, hypertension inflammation markers.CfDNA higher G2 G3 compared G1 sera. A...
We present immunogenicity data 6 months after the first dose of BNT162b2 in correlation with age, gender, BMI, comorbidities and previous SARS-CoV-2 infection.An evaluation was carried out among health care workers (HCW) vaccinated at Istituti Fisioterapici Ospitalieri (IFO). All HCW were asked to be vaccine by national campaign beginning 2021. Serum samples collected on day 1 just prior 21 second vaccination dose. Thereafter sera 28, 49, 84 168 days BNT162b2. Quantitative measurement IgG...
Background: The first goal of the study was to analyse antibody titre 21 days after dose BNT162b2 vaccine in a group 252 healthcare workers (HCW). second how changes correlation with age, gender and body mass index (BMI). Methods: Participants had nasopharyngeal swab for SARS-CoV-2 were assessed presence antibodies at baseline priming dose. Results: First activated immune responses 98% participants. Five HWC no increase Antibody greater young (<38 years) vs. older participants 47–56 p =...
Abstract Background Patients with solid or hematological tumors neurological and immune-inflammatory disorders are potentially fragile subjects at increased risk of experiencing severe coronavirus disease 2019 an inadequate response to acute respiratory syndrome 2 (SARS-CoV-2) vaccination. Methods We designed a prospective Italian multicenter study assess humoral T-cell responses SARS-CoV-2 vaccination in patients (n = 378) (ST), malignancies (HM), (ND), immunorheumatological diseases (ID)....
Cancer mortality is mainly caused by organ failure and thrombotic events. It has been demonstrated that NETosis, a chromatin release mechanism implemented neutrophils, may contribute to these lethal systemic effects. Our aim was investigate NETosis biomarkers in endometrial cancer (EC).The experiments were conducted on 21 healthy subjects (HS) with no gynecological conditions, 63 EC patients. To assess the presence of features, IHC IF performed using antibodies against citrullinated histone...
We assessed the immunogenicity and safety of BNT162b2 vaccine in a large cohort patients with cancer (CP).From March 1, 2021 to 20, 2021, this prospective study included 816 CP afferent our institution eligible for vaccination. A 274 health care workers (HCW) was used as age- sex-matched control group. administered two-dose regimen given 21 days apart. Blood samples analyze anti-Spike (S) IgG antibodies (Ab) were collected prevaccination [timepoint (TP) 0], at 3 weeks (TP1) 7 (TP2) after...
To investigate the thrombotic tendency in patients with systemic lupus erythematosus (SLE) by evaluating congenital or acquired abnormalities associated an increased risk of venous and/or arterial thrombosis.A total 57 SLE were included study. Twenty-one (37%) had a history thrombosis and 36 (63%) did not have such history. Sera from 50 healthy controls examined. Protein C, protein S, antithrombin, D-dimer, fibrinogen, homocysteine, anticardiolipin antibodies (aCL), anticoagulant (LAC),...
There is growing support for the idea that an impaired understanding of others' mental states underlying feature personality disorder (PD). Only recently has there begun to be evidence impairments subjects' ability infer and reason about intentions emotions, detach from their own perspective when doing so.We analysed transcripts first 16 psychotherapy sessions 14 PD patients. Scales minds Metacognition Assessment Scale were used.Patients generally able describe states, although, at times,...
The capacity of understanding mental states is a complex function which involves several components. Single components can be selectively impaired in specific clinical populations. It has been suggested that impairments mindreading are central for borderline personality disorder (BPD). However, empirical findings inconsistent, and it debatable whether BPD presents profile impairments. aim this study to compare other PDs mindreading. Seventy-two patients with 125 PD diagnoses were assessed...
The prevalence of fatigue and its relation with clinical, neuropsychological brain magnetic resonance imaging (MRI) variables in a large cohort multiple sclerosis (MS) patients was investigated.The Modified Fatigue Impact Scale subdomains were collected from 725 healthy controls 366 MS [238 relapsing-remitting (RRMS) 128 progressive (PMS)]. For the global subdomains, classified as fatigued (F-MS) or non-fatigued (NF-MS) according to cut-off values provided by logistic regression models...
Autoimmune atrophic gastritis (AAG) leads to iron and/or vitamin B12 malabsorption, with subsequent haematological alterations which could represent the sole clinical manifestation. We aimed assess patterns of anaemia and micronutrient deficiencies in patients AAG at time diagnosis.Observational, multicentre, cross-sectional study including consecutive adult diagnosed within last ten years. Cell blood count, red cell distribution width, serum B12, ferritin were collected. Multivariate...
Different psychotherapeutic approaches demonstrated their efficacy but the possible neurobiological mechanism underlying effect of psychotherapy in borderline personality disorder (BPD) patients is poorly investigated. We assessed effects metacognitive interpersonal therapy (MIT) on BPD features and other dimensions compared to structured clinical management (SCM). also changes amygdala activation by viewing emotional pictures after psychotherapy. One hundred forty-one were referred 78...
Platelet transfusions, main therapy of Glanzmann Thromboasthenia (GT), can induce an allo-immunization against human leucocyte antigen and integrin alphaIIbbeta3. We have investigated in our GT patients the rate refractoriness to platelet transfusions. From 1975 until December 2005, we followed 17 patients: 14 type 1, 3 variant type; nine females, eight males; median age at diagnosis 9.8 years (range 1-44.5); time study 35.5 23.6-68.5). In patients, 121 bleeding episodes occurred (24 severe,...