A5039373029- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- COVID-19 and healthcare impacts
- Epigenetics and DNA Methylation
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Head and Neck Cancer Studies
- SARS-CoV-2 detection and testing
- Cynara cardunculus studies
- Cancer Cells and Metastasis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatological and Skeletal Disorders
- Cell death mechanisms and regulation
- Eosinophilic Disorders and Syndromes
- Biomarkers in Disease Mechanisms
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Cancer Institute (WIA)
2025
Istituti Fisioterapici Ospitalieri
2022-2023
National Cancer Institute
2015-2022
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. They are typically characterized by a high incidence of local recurrence, which most common cause death in HNSCC patients. TP53 frequently mutated gene patients carrying mutations associated with higher probability to develop recurrence. MiRNAs, among mediators oncogenic activity mt-p53 protein, emerge as an appealing tool for screening, diagnosis prognosis cancer. We previously identified signature 12...
// Sara Donzelli 1 , Federica Mori 2 Teresa Bellissimo Andrea Sacconi Beatrice Casini 3 Tania Frixa Giuseppe Roscilli 4 Luigi Aurisicchio Francesco Facciolo 5 Alfredo Pompili 6 Maria Antonia Carosi Edoardo Pescarmona Oreste Segatto 7 Greg Pond 8 Paola Muti Stefano Telera Sabrina Strano 2,8 Yosef Yarden 9 and Giovanni Blandino 1,8 Translational Oncogenomics Unit, Italian National Cancer Institute 'Regina Elena', Rome, Italy Molecular Chemoprevention Department of Pathology, Takis s.r.l.,...
Cancer mortality is mainly caused by organ failure and thrombotic events. It has been demonstrated that NETosis, a chromatin release mechanism implemented neutrophils, may contribute to these lethal systemic effects. Our aim was investigate NETosis biomarkers in endometrial cancer (EC).The experiments were conducted on 21 healthy subjects (HS) with no gynecological conditions, 63 EC patients. To assess the presence of features, IHC IF performed using antibodies against citrullinated histone...
Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 oncoproteins stimulate de novo serine/glycine synthesis and essential acids intake, promoting breast growth. Mechanistically, p53, unlike the wild-type counterpart, induces expression serine-synthesis-pathway enzymes L-type transporter 1 (LAT1)/CD98 heavy chain heterodimer. This effect exacerbated shortage,...
The limited clinical response observed in high-grade serous ovarian cancer (HG-SOC) with high frequency of TP53 mutations (mutp53) might be related to mutp53-driven oncogenic pathway network. Here we show that β-arrestin1 (β-arr1), interacts YAP, triggering its cytoplasmic-nuclear shuttling. This interaction allows β-arr1 recruit mutp53 the YAP-TEAD transcriptional complex upon activation endothelin-1 receptors (ET-1R) patient-derived HG-SOC cells and cell lines bearing mutp53. In parallel,...
As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases, including cancer. Specifically, breast cancer tightly control angiogenic switch and progression malignancy. ID4, a member ID (inhibitors differentiation) family proteins, is associated with stem-like phenotype poor prognosis basal-like Moreover, ID4 favours angiogenesis by enhancing expression pro-angiogenic cytokines interleukin-8, CXCL1...
Abstract Evaluating the expression levels of miR-378a-5p both in a large melanoma patient cohort from The Cancer Genome Atlas database and patients our Institute, we found that is upregulated metastatic specimens. was also increased cells resistant to target therapy, decreased response drug treatment. We demonstrated overexpression enhances vitro cell invasion migration, facilitates ability form de novo vasculogenic structures. While performing downstream targeting studies, confirmed...
Glioblastoma is characterized by a high proliferative rate and drug resistance. The standard of care includes maximal safe surgery, followed radiotherapy temozolomide chemotherapy. expression glutamate receptors has been previously reported in human glioma cell lines. aim this study was to examine the cellular effects perampanel, broad-spectrum antiepileptic acting as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) antagonist, alone or combination with temozolomide....
Abstract Epithelial lineage differentiation is pivotal to mammary gland development and it can pause metastasis of breast cancer (BC) by inducing tumor dormancy. To simulate this, we expressed epithelial genes in mesenchymal BC cells. Inducible expression the OVOL metastatic cells suppressed proliferation migration. We found that C1ORF116 , an OVOL’s target, susceptible genetic epigenetic aberrations BC. It regulated steroids functions as a putative autophagy receptor inhibits antioxidants...
Abstract Background Altered metabolism is one of the cancer hallmarks. The role circRNAs in poorly studied. Specifically, impact circPVT1, a well-known oncogenic circRNA on triple negative breast mechanistically underexplored. Methods clinical significance circPVT1 expression levels was assessed human samples using digital PCR and genome atlas (TCGA) dataset. activity TNBC cell lines MCF-10 A line by either ectopic or depletion molecule. CircPVT1 mediated metabolic perturbation 1 H-NMR...
Epilepsy is a frequent symptom in patients with glioma. Although treatment antiepileptic drugs generally effective controlling seizures, drug-resistant are not uncommon. Multidrug resistance proteins (MRPs) and P-gp over-represented brain tissue of epilepsy, suggesting their involvement the clearance medications. In addition to anticonvulsant action, some have been documented for cytotoxic effects. Aim this study was evaluate possible vitro effects two new-generation on human glioma cell...
The AMP-activated protein kinase (AMPK) is a heterotrimeric complex that an important sensor of cellular energy status. Reduced expression the AMPK β1 isoform has been linked to reduced survival in different cancers, but whether this accelerates tumor progression and potential mechanism mediating these effects are not known. Furthermore, it unknown implicated tumorigenesis, if so, what tissues may be most sensitive. In current study, we find absence suppressor p53, germline genetic deletion...
Alteration in microRNAs (miRNAs) expression is a frequent finding human cancers. In particular, widespread miRNAs down-regulation hallmark of malignant transformation. the present report, we showed that miR-128-3p, which up-regulated lung cancer tissues, has Drosha and Dicer, two key enzymes processing, as main modulation targets leading to miRNA expression. We observed downregulation induced by miR-128-3p contributed tumorigenic properties cells. miR-128-3p-mediated aberrant SNAIL ZEB1...
MicroRNAs (miRNAs) might be considered both predictors and players of cancer development. The aim the present report was to investigate whether many years before diagnosis breast miRNA expression is already disregulated. In order test this hypothesis, we compared miRNAs extracted from leukocytes in healthy women who later developed remain during whole 15-year follow-up time. Accordantly, used a case-control study design nested hOrmone Diet ETiology (ORDET) prospective cohort addressing...
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of tumors, with aggressive clinical course that renders prognostication and choice treatment strategy difficult. Chemo-immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) the current first-line treatment. MicroRNAs (miRNAs) are under investigation as novel diagnostic prognostic biomarkers in several malignancies, including malignant lymphomas. While tissue miRNAs DLBCL patients have been...
Abstract Background SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by TMPRSS2 protease. We aim assess differences in both expression normal tissues from oral cavity, pharynx, larynx lung as well neoplastic same areas. Methods The study has been conducted using TCGA Regina Elena Institute databases validated experimental model HNSCC cells. also included data one COVID19 patient who went under surgery for HNSCC. Results was...