A5083898630- Head and Neck Cancer Studies
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- MicroRNA in disease regulation
- Tumors and Oncological Cases
- Soft tissue tumor case studies
- MRI in cancer diagnosis
- Cardiac tumors and thrombi
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Neurofibromatosis and Schwannoma Cases
- Gastrointestinal Tumor Research and Treatment
- Cancer and Skin Lesions
- Autophagy in Disease and Therapy
- Cutaneous Melanoma Detection and Management
- Cancer-related gene regulation
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Magna Graecia University
2024
Fincons Group (Italy)
2024
Istituti Fisioterapici Ospitalieri
2011-2022
Instituto Nazionale Tumori Regina Elena
2007-2019
National Cancer Institute
2007-2019
San Gallicano Hospital
2019
Fondazione IRCCS Istituto Nazionale dei Tumori
2019
Government of the Republic of Korea
2016
Tumori Foundation
2007-2015
To retrospectively compare the diagnostic accuracy of magnetic resonance imaging (MRI) and multidetector-row computed tomography (MDCT) in assessment mandibular invasion by squamous cell carcinoma (SCC) having histopathological exams as standard reference. Institutional review board approval with a waiver informed patient consent was obtained. Of 147 patients selected from our database who underwent surgical excision tumour arising into oral cavity, thirty-six (26 men, 10 women; mean age, 56...
Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with a high rate of recurrence. MicroRNAs (miRNAs) are gene regulators playing an important role in oral carcinogenesis. The purpose this study was for us to identify and functionally characterize miRNAs that predict recurrence OSCC.We collected 92 OSCC their normal tissue counterparts we performed expression profiling on 74 38 tissues. association between clinical outcome evaluated follow-up 69 patients.Four...
Mutation of TP53 gene is a hallmark head and neck squamous cell carcinoma (HNSCC) not yet exploited therapeutically. mutation frequently leads to the synthesis mutant p53 proteins with gain-of-function activity, associated radioresistance high incidence local recurrences in HNSCC.Mutant p53-associated functions were investigated through set enrichment analysis Cancer Genome Atlas cohort HNSCC panel 22 lines. Mutant p53-dependent transcripts analyzed line Cal27, carrying p53H193L; FaDu,...
This work describes the set-up of a shared platform among laboratories Alleanza Contro il Cancro (ACC) Italian Research Network for identification fusion transcripts in sarcomas by using Next Generation Sequencing (NGS). Different NGS approaches, including anchored multiplex PCR and hybrid capture-based panels, were employed to profile large set different histotypes. The analysis confirmed reliability RNA-based approaches detecting sarcoma-specific rearrangements. Overall, assay proved be...
Abstract Background Rhinosporidiosis is a disease affecting primarily the mucosa of nose, conjunctiva and urethra. It endemic in some Asiatic regions, people any age sex. Its manifestation polypoid mass growing inside affected cavity only treatment surgical excision. Rhinosporidium seeberi aetiological agent. Many discussions arouse regarding taxonomic classification microorganism, recent studies established it an aquatic protistan parasite. The lesion may recur sometimes cause osteolytic...
<i>Background:</i> The dermoscopic patterns of pigmented skin tumors are influenced by the body site. <i>Objective:</i> To evaluate clinical and features associated with vulvar lesions. <i>Methods: </i>Retrospective analysis images χ<sup>2</sup> test was used to association between data histopathological diagnosis. <i>Results:</i> A total 42 (32.8%) melanocytic 86 (67.2%) nonmelanocytic lesions were analyzed. Nevi significantly...
Head and neck squamous cell carcinoma is typically characterized by a high incidence of local recurrences. It has been extensively shown that mucosa from head patients carries both genetic gene expression alterations, which are mostly attributable to major etiologic agents carcinoma. We previously identified signature microRNAs (miRNAs) whose in tumors predictive recurrence. Here, we investigated whether the deregulation miRNA tumor-surrounding correlated disease Specifically, comparing...
The differentiation between benign and malignant parotid lesions is crucial to defining the treatment plan, which highly depends on tumor histology. We aimed evaluate role of MRI-based radiomics using both T2-weighted (T2-w) images Apparent Diffusion Coefficient (ADC) maps in lesions, order develop predictive models with an external validation cohort.A sample 69 untreated was evaluated retrospectively, including 37 (of 13 were Warthin's tumors) 32 tumors. patient population divided into...
(1) Background: Oral tongue squamous cell carcinoma (OTSCC) is a prevalent malignancy with high loco-regional recurrence. Advanced imaging biomarkers are critical for stratifying patients at risk of This study aimed to develop MRI-based radiomic models predict recurrence in OTSCC undergoing surgery. (2) Methods: We retrospectively selected 92 who underwent MRI, followed by surgery and cervical lymphadenectomy. A total 31 suffered from Radiomic features were extracted preoperative...
Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing world health problem with a more favorable prognosis for patients human papillomavirus (HPV)-positive tumors compared to those HPV-negative OPSCC. How HPV confers less aggressive phenotype, however, remains undefined. We demonstrated that HPV-positive OPSCC cells display reduced macroautophagy/autophagy activity, mediated by the ability of HPV-E7 interact AMBRA1, compete its binding BECN1 and trigger calpain-dependent...
Abstract Background The purpose of this multicenter study was to retrospectively investigate the prognostic significance tumor microenvironment, in relation survival a large cohort patients with laryngeal squamous cell carcinoma (LSCC), using method proposed by International TILs Working Group breast cancer. Methods All consecutive biopsy‐proven LSCC who underwent total laryngectomy (TL) between January 2014 and 2023 were included study. A retrospective review medical records including...
Abstract Background The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors the development certain cutaneous squamous cell carcinomas. However, only few reports contain on basal carcinoma (BCC). HPVs interact with many cellular proteins altering their function or expression levels, like p16 INK4a Akt. Our study aimed to determine presence different beta -HPV types Akt BCC,...
Limited information is available on the applicative value of liquid biopsy (LB) in rare tumors, including Ewing's sarcoma (ES). The accepted precision diagnostics standards would greatly benefit from a non-invasive LB test monitoring pathognomonic gene rearrangements bloodstream.Tissue and blood samples were collected six four ES patients, respectively. Plasma was cleared by two successive rounds centrifugation stored frozen until RNA extraction QIAmp CNA kit. retro-transcribed subjected to...
Although the medical treatments of sarcoma have evolved in last years, a significant portion patients develops recurrence after therapies suggesting need to identify novel targets improve treatments. By use patient-derived and established cell lines from liposarcoma, as well specimens patient biopsies, we found that HMGA1 is involved progression dedifferentiated myxoid liposarcoma. The immunohistochemical RT-PCR analyses 68 liposarcoma revealed high expression HMGA1, at protein RNA levels,...
Background The 8th edition of tumor, node, metastasis (TNM) classification incorporates depth invasion evaluation in the staging oral cavity squamous cell carcinoma, since it is a predictor nodal and an independent prognostic factor. Although histopathological definition clear, accurate method for its radiological assessment has not yet been validated. Purpose To investigate role MRI-derived tongue carcinoma to assess inter-reader agreement radiological–pathological correlation. Material...
Vulvar melanosis is a benign pigmented lesion that may clinically mimic melanoma. Whereas the dermoscopic features of other skin lesions have been extensively described, little known about vulvar melanosis.A retrospective study was conducted on 87 with histopathologically proved melanosis. We describe and define, for first time to our knowledge, ringlike pattern, found in 28 melanotic (32%), characterized by multiple round oval structures, white tan, dark brown, well-defined regular borders....
Abstract Background Liposarcoma is one of the most common soft tissue sarcoma adult life, usually occurring in retroperitoneum and extremities. Primary liposarcoma colon very rare. The optimal treatment has not been established due to small number cases reported. We report a case primary presenting as massive intraluminal lesion. Case presentation A 79-year-old woman presented with abdominal pain, progressive constipation weight loss. CT scan colonoscopy revealed an mass transverse multiple...
Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinomas (OPSCC) show better prognosis and response to therapy. We evaluated HPV-DNA prevalence, p16 overexpression HPV-attributable fraction in recent consecutive OPSCCs.140 OPSCCs were analyzed for using the INNO-LiPA assay CINtec® Histology kit.HPV-DNA prevalence was 40.7%, significantly higher basaloid nonkeratinizing SCCs, but similar tonsillar base of tongue SCCs. Moreover, 98.0% HPV-positive overexpressed p16,...
Objective Cervical lymph node fine needle aspirates ( FNA s) may represent the only specimens available for an initial characterisation of patients with lymphadenopathy. Morphology and human papillomavirus HPV) DNA presence were evaluated in s collected from oropharyngeal squamous cell carcinoma OPSCC ) or cancer unknown primary CUP ). HPV results compared those respective formalin‐fixed paraffin‐embedded FFPE cancer. Methods Liquid‐based cytology was performed on PreservCyt. ‐ analysed by...
Globally, 30% of oropharyngeal carcinomas (OPSCC) are caused by Human Papillomavirus (HPV). Recently, increasing incidence trends for HPV-driven OPSCC have been reported in many countries and changes the typical HPV-positive patient recorded, with an increase median age diagnoses women. We investigated characteristics patients attending Italian Cancer Institute from 2010 to 2019 assessed possible overtime demographic, behavioral, clinico-pathologic variables OPSCC. Overall, 339 OPSCCs were...