A5086047268- Cervical Cancer and HPV Research
- Genital Health and Disease
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- Molecular Biology Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Oral Health Pathology and Treatment
- Cancer-related Molecular Pathways
- T-cell and B-cell Immunology
- Viral-associated cancers and disorders
- HIV/AIDS oral health manifestations
- HER2/EGFR in Cancer Research
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- MRI in cancer diagnosis
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis B Virus Studies
- Medical Imaging Techniques and Applications
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Glycosylation and Glycoproteins Research
- Reproductive tract infections research
- Salivary Gland Tumors Diagnosis and Treatment
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Fondazione IRCCS Istituto Nazionale dei Tumori
2025
Instituto Nazionale Tumori Regina Elena
2025
Massachusetts General Hospital
2015-2023
Beth Israel Deaconess Medical Center
2023
The University of Texas MD Anderson Cancer Center
2023
Università Cattolica del Sacro Cuore
2018-2023
Faculty of Media
2023
National Cancer Institute
2023
San Gallicano Hospital
2019
We conducted a large international study to estimate fractions of head and neck cancers (HNCs) attributable human papillomavirus (HPV-AFs) using six HPV-related biomarkers viral detection, transcription, cellular transformation. Formalin-fixed, paraffin-embedded cancer tissues the oral cavity (OC), pharynx, larynx were collected from pathology archives in 29 countries. All samples subject histopathological evaluation, DNA quality control, HPV-DNA detection. Samples containing further HPV...
ABSTRACT There is evidence that testing for human papillomavirus (HPV) E6/E7 mRNA more specific than HPV DNA. A retrospective study was carried out to evaluate the performance of PreTect HPV-Proofer assay (Norchip) as a triage test cytology and DNA testing. This analyzed 1,201 women, 688 whom had colposcopy follow-up 195 histology-confirmed high-grade intraepithelial neoplasia or worse (CIN2+). The proportion positive results sensitivity specificity CIN2+ were determined in comparison...
The study presents cross-sectional accuracy of E6 and E7 (E6/E7) mRNA detection p16/ki67 dual staining, alone or in combination with cytology human papillomavirus (HPV)16/18 genotyping, as a triage test HPV DNA-positive women their impact on cervical intraepithelial neoplasia (CIN2+) overdiagnosis.
As the primary screening test, E6/E7 mRNA has shown similar sensitivity for CIN3+ and lower positivity rate than HPV DNA test. Nevertheless, overall is too high immediate colposcopy, making a triage test necessary. The aim was to estimate performance as with different strategies. All DNA-positives were tested mRNA, cytology p16/ki67. A sample of DNA-negatives also specificity. We included all histologically diagnosed within 24 months since recruitment. Of 41 127 participants, 7.7%...
PURPOSE Among the clinical factors with a pivotal role in prediction of outcome for patients gastric cancer, intraperitoneal (i.p.) microscopic dissemination may represent an important cause recurrences, even early stages disease. In this context, cytologic examination intraoperative peritoneal washings be essential to identify metastatic free cells, although number false-negative cases encountered. PATIENTS AND METHODS To determine whether immunocytochemical (ICC) methods that used panel...
Abstract Background Human Leukocyte Antigen (HLA)-E is a non-classical class I HLA molecule that can be stabilized by ligands donated other classical (HLA-A, -B, -C) and (HLA-G) family members. HLA-E engages variety of immune receptors expressed cytotoxic T lymphocytes (CTLs), Natural killer (NK) cells NK-CTLs. In view the opposing outcomes (activation or inhibition) different receptors, preferred role (if any) in vivo on tumor remains to established. Methods Taking advantage MEM-E/02,...
Aims The introduction of immunotherapy for patients with head and neck squamous cell carcinoma (HNSCC) raises the need harmonisation between different types antibody immunohistochemistry platform evaluating expression PD‐L1 by use combined positive score (CPS) in this tumour. aim study was to compare as determined CPS two widely used assays (the 22C3 PharmDx assay SP263 assay) a cohort HNSCCs. Methods results We analysed 43 whole sections HNSCC anti‐PD‐L1 antibodies, SP263. results,...
Head and neck squamous cell carcinoma is typically characterized by a high incidence of local recurrences. It has been extensively shown that mucosa from head patients carries both genetic gene expression alterations, which are mostly attributable to major etiologic agents carcinoma. We previously identified signature microRNAs (miRNAs) whose in tumors predictive recurrence. Here, we investigated whether the deregulation miRNA tumor-surrounding correlated disease Specifically, comparing...
Microbiome gained attention as a cofactor in cancers originating from epithelial tissues. High-risk (hr)HPV infection causes oropharyngeal squamous cell carcinoma but only fraction of hrHPV+ individuals, suggesting that other factors play role cancer development. We investigated oral microbiome cancer-free subjects harboring hrHPV (n = 33) and matched HPV− controls 30). DNA purified rinse-and-gargles HIV-infected (HIV+) HIV-uninfected (HIV−) individuals were used for 16S rRNA gene V3–V4...
Abstract The International Anal Neoplasia Society (IANS) has generated recommendations for anal cancer screening, identifying men who have sex with (MSM) living human immunodeficiency virus (HIV; MSM-LWH) ≥35 years and MSM not HIV (MSM-noHIV) ≥45 as groups to prioritize. As high-resolution anoscopy (HRA) availability is still limited across Europe, a retrospective study was conducted estimate the potential HRA referral rates of Sexually Transmitted Infections (STI)/HIV center European...
<p>Supplementary Figure S1. Outline of the different screening strategies, showing categories referred for high-resolution anoscopy (HRA) and those re-screening with corresponding interval. hrHPV: high-risk Human Papillomavirus; Low, settings insufficient HRA capacity.</p>
<div>Abstract<p>The International Anal Neoplasia Society (IANS) has generated recommendations for anal cancer screening, identifying men who have sex with (MSM) living human immunodeficiency virus (HIV; MSM-LWH) ≥35 years and MSM not HIV (MSM-noHIV) ≥45 as groups to prioritize. As high-resolution anoscopy (HRA) availability is still limited across Europe, a retrospective study was conducted estimate the potential HRA referral rates of Sexually Transmitted Infections (STI)/HIV...
Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing world health problem with a more favorable prognosis for patients human papillomavirus (HPV)-positive tumors compared to those HPV-negative OPSCC. How HPV confers less aggressive phenotype, however, remains undefined. We demonstrated that HPV-positive OPSCC cells display reduced macroautophagy/autophagy activity, mediated by the ability of HPV-E7 interact AMBRA1, compete its binding BECN1 and trigger calpain-dependent...
HIV-infected men who have sex with (MSM) display the highest prevalence of anal infection by high-risk Human Papillomaviruses (hrHPVs) and incidence carcinoma. Anal specimens were genotyped Linear Array. Incidence clearance hrHPVs, hrHPVs other than HPV16, low-risk HPVs, four individual types (6,11,16,18) estimated using a two-state Markov model. Determinants for assessed logistic regression. Overall, 204 individuals included (median age 42 years, IQR = 34-49). For rates 36.1 × 1000...
Abstract Background First aim was to compare ddPCR assays of ctHPVDNA with p16 IHC and qualitative HPV PCR. Second carry out longitudinal blood sampling test for association histological confirmed recurrence. Third perform a multidimensional assessment which included: (1) clinical features; (2) ctHPVDNA; (3) MRI‐based tumor size measurements primary (PT) cervical lymph node metastases (CLNM). Methods Plasma samples were collected before treatment during follow‐up, assay comprising E6 HPV16...