A5045356687- Cervical Cancer and HPV Research
- Genital Health and Disease
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Reproductive tract infections research
- Colorectal and Anal Carcinomas
- Radioactivity and Radon Measurements
- Head and Neck Cancer Studies
- HER2/EGFR in Cancer Research
- Tuberculosis Research and Epidemiology
- Radiation Dose and Imaging
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Appendicitis Diagnosis and Management
- Viral-associated cancers and disorders
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Nuclear Physics and Applications
- Lung Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2020
Istituti Fisioterapici Ospitalieri
2012
Tumori Foundation
1991-2011
Instituto Nazionale Tumori Regina Elena
1991-2011
Cancer Institute (WIA)
2000-2009
National Cancer Institute
2006
Italian Association for Cancer Research
2000
Ministero della Salute
2000
Presidio Ospedaliero
1982-1985
ABSTRACT There is evidence that testing for human papillomavirus (HPV) E6/E7 mRNA more specific than HPV DNA. A retrospective study was carried out to evaluate the performance of PreTect HPV-Proofer assay (Norchip) as a triage test cytology and DNA testing. This analyzed 1,201 women, 688 whom had colposcopy follow-up 195 histology-confirmed high-grade intraepithelial neoplasia or worse (CIN2+). The proportion positive results sensitivity specificity CIN2+ were determined in comparison...
In Italy, the cohorts of women who were offered Human papillomavirus (HPV) vaccination in 2007/08 will reach age (25 years) for cervical cancer (CC) screening from 2017. The simultaneous shift cytology-based to HPV test-based gives opportunity unprecedented reorganisation CC prevention. ONS (National Screening Monitoring Centre) Directive and GISCi (Italian Group Cervical Screening) identified consensus conference as most suitable method addressing this topic. A summary recommendations is...
Abstract Learning Objectives After completing this course, the reader will be able to: Explain importance of an accurate evaluation HER-2 status to select breast cancer patients for trastuzumab therapy.Describe current methods that assess in cancer.Discuss advantages and limits CISH method detection HER-2/neu gene amplification histology ThinPrep®-processed fine-needle aspirates. Access take CME test online receive 1 AMA PRA Category Credit™ at CME.TheOncologist.com The increasing evidence...
This study presents direct evidence that dissociated chondroblasts from rabbit ear cartilage grown in vitro are capable of synthesizing insoluble elastin. Ultrastructural examination indicated at an early stage tissue development, elastogenesis is initiated producing a form primary fibrils which later condense into electron dense amorphous material which, unlike other elastin-containing tissues, heavily stained by metal cations and lacks peripheral microfibrils. Native elastic the mature...
Cervical cancer represents an important global public health problem. It is the 2nd most common among women worldwide. Human Papillomavirus (HPV) infection now well-established as a necessary cause of invasive cervical (ICC) development. Only few studies on HPV prevalence and type-specific distribution in ICC have been conducted Italy. To describe cases identified Rome, 140 paraffin embedded tissue blocks primary diagnosed between 2001 2006 were at Regina Elena Cancer Institute Rome (Italy)....
The incidence of anal cancer, a Human Papillomavirus (HPV)-related neoplasia, has been increasing in recent decades, mainly men who have sex with (MSM). Cytological changes the epithelium induced by HPV can be detected through an pap smear. This study aimed to evaluate prevalence and epidemiological correlates cytological abnormalities among relatively young MSM at risk for HIV-1 infection, help clarify whether or not this population deserves further investigation assess presence cancer...
Abstract Genital human papillomavirus (HPV) is the causative agent of cervical cancer and most common sexually transmitted infection. Only limited controversial data are available regarding HPV transmission in male sexual partners women with intraepithelial neoplasia (CIN). The aim this study was to investigate prevalence genotype distribution penile scrapings a series Italian men, who had no visible lesions were affected, or been affected previously by infected HPV. concordance viral group...
Pap test, and especially HPV DNA identify a large group of women who do not have any clinically relevant lesions, i.e., CIN2+ (Cervical Intraepithelial Neoplasia grade 2 or worse), but are at greater risk getting lesions in the future. The follow up these needs new biomarkers with prognostic value. objective this study is to evaluate value E6/E7 mRNA over-expression assay (PreTect HPV-Proofer, Norchip) for 5 HR-HPV types (16, 18, 31, 33, 45) progression after negative colposcopy. This...
BACKGROUND The increasing incidence of human papillomavirus (HPV)‐related head and neck squamous cell carcinoma (HNSCC) highlights the need for simple effective tools to evaluate lesions their HPV status. main objective current study was investigate association between abnormal cytology infection, assessed on cytobrushing samples, histologically confirmed HNSCC. Second, authors attempted whether status samples reflected that tumoral tissue. METHODS A total 164 from HNSCC, nonmalignant...
p16INK4a is overexpressed in high-risk human papillomavirus (HR-HPV)-infected preneoplastic and neoplastic lesions of the uterine cervix. Our aim was to verify whether p16 a diagnostic marker also cervical liquid-based cytology. We performed immunocytochemical analysis Hybrid Capture 2 (HC2) test (Digene, Gaithersburg, MD) for HR-HPV infection 471 ThinPrep-processed (Cytyc, Boxborough, MA) cervicovaginal samples correlated results with histologic findings. A total 32.3% specimens showed...
The aim of this study is to describe the prevalence HPV types in invasive cervical cancers Italy from 1996 2008. A pooled analysis three largest case series typed date was performed. typing performed on paraffin-embedded slices. Molecular analyses were four laboratories. Multivariate test associations between calendar time, age, and geographical area proportion 16/18. Out 574 cancers, 24 (4.2%) negative. 16 18 responsible for 74.4% (378/508) 80.3% (49/61) squamous adenocarcinomas,...