A5079974622- Cervical Cancer and HPV Research
- Genital Health and Disease
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- Viral-associated cancers and disorders
- Oral Health Pathology and Treatment
- HIV/AIDS oral health manifestations
- Syphilis Diagnosis and Treatment
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- HIV, Drug Use, Sexual Risk
- Reproductive tract infections research
- Immunotherapy and Immune Responses
- Molecular Biology Techniques and Applications
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- Nonmelanoma Skin Cancer Studies
- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- Animal Virus Infections Studies
- Head and Neck Surgical Oncology
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
San Gallicano Hospital
2016-2025
Virginia Commonwealth University
2018
Hudson Institute
2018
University Health Network
2018
Massachusetts General Hospital
2018
Università Cattolica del Sacro Cuore
2018
John Wiley & Sons (United States)
2018
University of Louisville
2011
Istituto Superiore di Sanità
2005-2007
Dear Editor, In response to the COVID-19 pandemic, on 9 March 2020, Italian government announced a nationwide lockdown programme of social distancing, self-isolation for contacts and prohibition public events. People with other medical needs were still able attend hospital outpatient appointments provided they carried printed self-certification explain reason journey an inspection by police. Throughout period, STI/HIV Unit San Gallicano Dermatological Institute, largest clinic in Rome, has...
Abstract Background Understanding the natural history of anal high-risk human papillomavirus (hrHPV) infection is key for designing cancer prevention programs but has not been systematically characterized. Methods We reanalyzed data from 34 studies including 16 164 individuals in 6 risk groups defined by immunodeficiency virus (HIV) status, sex, and male sexuality: men who have sex with (MSM) people HIV (MSMWH), HIV-negative MSM, women (WWH), women, (MSW) (MSWWH), MSW. used Markov models to...
Data on COVID-19 boosting vaccination in people living with HIV (PLWH) are scant. We investigated the immunogenicity and safety of BNT162b2 homologous vaccination. Anti-SARS-CoV-2 spike antibodies (LIAISON® SARS-CoV-2 S1/S2 IgG test, DiaSorin®), CD4+, CD8+ viraemia were monitored at T0 (pre-vaccination), T1 (4 weeks after second dose), T2 (pre-booster) T3 booster dose). Humoral responses evaluated according to sex, age, BMI, nadir baseline CD4+ counts, as well type cART regimen. Forty-two...
Microbiome gained attention as a cofactor in cancers originating from epithelial tissues. High-risk (hr)HPV infection causes oropharyngeal squamous cell carcinoma but only fraction of hrHPV+ individuals, suggesting that other factors play role cancer development. We investigated oral microbiome cancer-free subjects harboring hrHPV (n = 33) and matched HPV− controls 30). DNA purified rinse-and-gargles HIV-infected (HIV+) HIV-uninfected (HIV−) individuals were used for 16S rRNA gene V3–V4...
Abstract The International Anal Neoplasia Society (IANS) has generated recommendations for anal cancer screening, identifying men who have sex with (MSM) living human immunodeficiency virus (HIV; MSM-LWH) ≥35 years and MSM not HIV (MSM-noHIV) ≥45 as groups to prioritize. As high-resolution anoscopy (HRA) availability is still limited across Europe, a retrospective study was conducted estimate the potential HRA referral rates of Sexually Transmitted Infections (STI)/HIV center European...
HIV-infected men who have sex with (MSM) display the highest prevalence of anal infection by high-risk Human Papillomaviruses (hrHPVs) and incidence carcinoma. Anal specimens were genotyped Linear Array. Incidence clearance hrHPVs, hrHPVs other than HPV16, low-risk HPVs, four individual types (6,11,16,18) estimated using a two-state Markov model. Determinants for assessed logistic regression. Overall, 204 individuals included (median age 42 years, IQR = 34-49). For rates 36.1 × 1000...
Oral Human Papillomavirus (HPV) infection is rare in the general population but common high-risk individuals. Recent data indicate that oral HPV associated with development of head and neck carcinomas. HPV16 infection, particular, increases risk oropharyngeal cancer.We evaluated prevalence determinants cancer-free HIV-infected uninfected men who have sex (MSM) recruited among attendees an STI/HIV centre. rinse gargles were collected using a mouthwash analyzed Linear Array Genotyping Test....
The incidence of anal cancer, a Human Papillomavirus (HPV)-related neoplasia, has been increasing in recent decades, mainly men who have sex with (MSM). Cytological changes the epithelium induced by HPV can be detected through an pap smear. This study aimed to evaluate prevalence and epidemiological correlates cytological abnormalities among relatively young MSM at risk for HIV-1 infection, help clarify whether or not this population deserves further investigation assess presence cancer...
Human papillomavirus (HPV) associated oropharyngeal squamous cell carcinomas (OPSCC) show better prognosis and response to therapy. We evaluated HPV-DNA prevalence, p16 overexpression HPV-attributable fraction in recent consecutive OPSCCs.140 OPSCCs were analyzed for using the INNO-LiPA assay CINtec® Histology kit.HPV-DNA prevalence was 40.7%, significantly higher basaloid nonkeratinizing SCCs, but similar tonsillar base of tongue SCCs. Moreover, 98.0% HPV-positive overexpressed p16,...
Objective Cervical lymph node fine needle aspirates ( FNA s) may represent the only specimens available for an initial characterisation of patients with lymphadenopathy. Morphology and human papillomavirus HPV) DNA presence were evaluated in s collected from oropharyngeal squamous cell carcinoma OPSCC ) or cancer unknown primary CUP ). HPV results compared those respective formalin‐fixed paraffin‐embedded FFPE cancer. Methods Liquid‐based cytology was performed on PreservCyt. ‐ analysed by...
Actinic keratosis (AK) arises on photo-damaged skin and is considered to be the precursor lesion of cutaneous squamous cell carcinoma (cSCC). Many findings support involvement β human papillomaviruses (HPVs) in cSCC, while very little known γ HPV types. The objective this study was characterize spectrum PV types healthy (HS) AK samples same immunocompetent individuals using next generation sequencing (NGS). Viral DNA 244 242 HS specimens were amplified by PCR two different sets primers...
Globally, 30% of oropharyngeal carcinomas (OPSCC) are caused by Human Papillomavirus (HPV). Recently, increasing incidence trends for HPV-driven OPSCC have been reported in many countries and changes the typical HPV-positive patient recorded, with an increase median age diagnoses women. We investigated characteristics patients attending Italian Cancer Institute from 2010 to 2019 assessed possible overtime demographic, behavioral, clinico-pathologic variables OPSCC. Overall, 339 OPSCCs were...
Anal Squamous Cell Carcinoma (SCCA) is a rare Human Papillomavirus type 16 (HPV16)-associated carcinoma whose pathogenesis still poorly understood. Recent studies based on biopsy and Next Generation Sequencing (NGS) approaches have linked the viral episomal status to aggressive SCCA phenotypes, suggesting potential role of 16E5 oncoprotein in tumor development. Our previous findings indicated that induces Fibroblast Growth Factor Receptor 2 (FGFR2) isoform switching, aberrant mesenchymal...