A5057227165- Cervical Cancer and HPV Research
- Genital Health and Disease
- SARS-CoV-2 and COVID-19 Research
- Colorectal and Anal Carcinomas
- Hepatitis C virus research
- HIV/AIDS oral health manifestations
- Oral Health Pathology and Treatment
- Syphilis Diagnosis and Treatment
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- HIV, Drug Use, Sexual Risk
- Poxvirus research and outbreaks
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Infectious Diseases and Mycology
- Developmental Biology and Gene Regulation
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Healthcare Systems and Challenges
- Public Health Policies and Education
- Cognitive Abilities and Testing
- SARS-CoV-2 detection and testing
- Dermatological diseases and infestations
- vaccines and immunoinformatics approaches
San Gallicano Hospital
2021-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2025
Massachusetts General Hospital
2023
Beth Israel Deaconess Medical Center
2023
The University of Texas MD Anderson Cancer Center
2023
Università Cattolica del Sacro Cuore
2023
Faculty of Media
2023
Sapienza University of Rome
1992-2020
Data on COVID-19 boosting vaccination in people living with HIV (PLWH) are scant. We investigated the immunogenicity and safety of BNT162b2 homologous vaccination. Anti-SARS-CoV-2 spike antibodies (LIAISON® SARS-CoV-2 S1/S2 IgG test, DiaSorin®), CD4+, CD8+ viraemia were monitored at T0 (pre-vaccination), T1 (4 weeks after second dose), T2 (pre-booster) T3 booster dose). Humoral responses evaluated according to sex, age, BMI, nadir baseline CD4+ counts, as well type cART regimen. Forty-two...
Microbiome gained attention as a cofactor in cancers originating from epithelial tissues. High-risk (hr)HPV infection causes oropharyngeal squamous cell carcinoma but only fraction of hrHPV+ individuals, suggesting that other factors play role cancer development. We investigated oral microbiome cancer-free subjects harboring hrHPV (n = 33) and matched HPV− controls 30). DNA purified rinse-and-gargles HIV-infected (HIV+) HIV-uninfected (HIV−) individuals were used for 16S rRNA gene V3–V4...
Abstract The International Anal Neoplasia Society (IANS) has generated recommendations for anal cancer screening, identifying men who have sex with (MSM) living human immunodeficiency virus (HIV; MSM-LWH) ≥35 years and MSM not HIV (MSM-noHIV) ≥45 as groups to prioritize. As high-resolution anoscopy (HRA) availability is still limited across Europe, a retrospective study was conducted estimate the potential HRA referral rates of Sexually Transmitted Infections (STI)/HIV center European...
Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the subtype with worst clinical outcome. However, importance of individual receptors TNBC and their specific mechanism action remain to be elucidated, even if recent findings suggested a role activated-Notch3 subset TNBCs. Epidermal growth factor receptor (EGFR) overexpressed TNBCs but use anti-EGFR agents (including tyrosine kinase inhibitors, TKIs) not approved for treatment...
HIV-infected men who have sex with (MSM) display the highest prevalence of anal infection by high-risk Human Papillomaviruses (hrHPVs) and incidence carcinoma. Anal specimens were genotyped Linear Array. Incidence clearance hrHPVs, hrHPVs other than HPV16, low-risk HPVs, four individual types (6,11,16,18) estimated using a two-state Markov model. Determinants for assessed logistic regression. Overall, 204 individuals included (median age 42 years, IQR = 34-49). For rates 36.1 × 1000...
Anal Squamous Cell Carcinoma (SCCA) is a rare Human Papillomavirus type 16 (HPV16)-associated carcinoma whose pathogenesis still poorly understood. Recent studies based on biopsy and Next Generation Sequencing (NGS) approaches have linked the viral episomal status to aggressive SCCA phenotypes, suggesting potential role of 16E5 oncoprotein in tumor development. Our previous findings indicated that induces Fibroblast Growth Factor Receptor 2 (FGFR2) isoform switching, aberrant mesenchymal...
Abstract Several studies had been carried out on anti‐hepatitis C virus (HCV) prevalence in populations with blood exposure risks and donors. New tests are now available which allow the in‐ vestigation to extend other parameters such as antibody type HCV‐RNA. In this study of anti‐HCV c100‐3 associated epidemiological, clinical, virological markers were evaluated subjects from an urban population located central Italy. positive cases time persistence HCV‐ RNA pattern was studied. For...
Unfolded protein response (UPR) is a conserved adaptive that tries to restore homeostasis after endoplasmic reticulum (ER) stress. Recent studies highlighted the role of UPR in acute leukemias and targeting has been suggested as therapeutic approach. Aberrant Notch signaling common feature T-cell lymphoblastic leukemia (T-ALL), downregulation activity negatively affects T-ALL cell survival, leading employment inhibitors therapy. Here we demonstrate Notch3 able sustain cells, silencing...
ABSTRACT Background Anal cytology represents a tool for anal cancer screening in high‐risk populations. In addition to accuracy, the reproducibility of interpretation is key importance. The authors evaluated agreement cytologic between two cytopathologists. Methods Liquid‐based slides from human immunodeficiency virus (HIV)‐negative men who have sex with (MSM) were by readers at least 10 years expertise cervical cytology. Cases discordant reviewed, and consensus was reached. Human...
The SARS-CoV-2 Variants of Concern tracking via Whole Genome Sequencing represents a pillar public health measures for the containment pandemic. ability to track down lineage distribution on local and global scale leads better understanding immune escape adopting interventions contain novel outbreaks. This scenario poses challenge NGS laboratories worldwide that are pressed have both faster turnaround time high-throughput processing swabs sequencing analysis. In this study, we present an...
Aim: Men who have sex with men (MSM) harbor a significant burden of human papillomavirus (HPV)-related diseases that could be prevented by vaccination. Materials & methods: Prevalence HPVs targeted the quadrivalent (4vHPV) and nonavalent vaccines (9vHPV) was assessed in anal (n = 443) oral 193) specimens immunocompetent, sexually active MSM, using Linear Array. Results: Of samples, 34.1 46.0% were positive for at least one genotype those covered 4vHPV 9vHPV, respectively. At 9vHPV detected...
Abstract Introduction Anal cytology is used in the prevention of anal cancer, which disproportionally affects men who have sex with (MSM). Data on incidence cytologic abnormalities these individuals are scant. Methods MSM baseline negative and at least one further adequate were included. Incidence rate for positive atypical squamous cells undetermined significance (ASC‐US+) was calculated. Kaplan–Meier curves compared by log‐rank test according to HIV status, high‐risk human papillomavirus...