A5071841724- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- melanin and skin pigmentation
- Genetic and rare skin diseases.
- Hedgehog Signaling Pathway Studies
- Tumors and Oncological Cases
- Immunotherapy and Immune Responses
- Dermatologic Treatments and Research
- thermodynamics and calorimetric analyses
- Respiratory Support and Mechanisms
- Acne and Rosacea Treatments and Effects
- Infrared Thermography in Medicine
- Dermatological diseases and infestations
- Melanoma and MAPK Pathways
- Infectious Diseases and Mycology
- COVID-19 and healthcare impacts
- CAR-T cell therapy research
- Skin Diseases and Diabetes
San Gallicano Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Istituti Fisioterapici Ospitalieri
2011-2025
Instituto Nazionale Tumori Regina Elena
2009
Fondazione IRCCS Istituto Nazionale dei Tumori
2009
Vismodegib and sonidegib are smoothened (SMO) inhibitors approved for the treatment of advanced basal cell carcinoma (aBCC). This study investigates real-world experiences outcomes associated with these therapies across multiple Italian centers. A retrospective, observational, multicenter was conducted. Medical records patients local (laBCC) treated SMO outside clinical trials from July 2019 to April 2024 were analyzed. total 57 included in study, 19 (33.3%) receiving vismodegib 38 (66.7%)...
Biological drugs have dramatically changed the approach to treating moderate-to-severe plaque psoriasis, achieving excellent skin clearance and safety outcomes. However, management of difficult-to-treat areas (e.g., scalp, palms/soles, nails, genitalia) still represents a challenge in psoriasis treatment. Data literature on sites are limited and, frequently, no specific analysis is performed during clinical trials. We conducted 52-week, retrospective study evaluate effectiveness ixekizumab...
Purpose of the article: Interleukin-23 inhibitors, such as tildrakizumab, have emerged safe and effective options for management psoriasis. Yet their efficacy in elderly patients (aged 65 years or more), particularly those with difficult-to-treat areas involvement, remains insufficiently explored. We conducted this real-life retrospective multicentric observational study to assess effectiveness tildrakizumab moderate-to-severe psoriasis, involvement areas.Materials methods: enrolled...
The management of plaque psoriasis that affects difficult-to-treat areas can be challenging. Biologics have become the treatment choice for moderate-to-severe psoriasis. However, there are limited data on their efficacy in sites (including scalp, palms/soles, nails and genitalia). We conducted a 52-week retrospective study to evaluate effectiveness risankizumab 202 patients with involvement at least one area. One hundred sixty-five had scalp psoriasis, 21 palms or soles, 72 were affected by...
Introduction: Skin cancer prevention campaigns aim to reduce modifiable risk factors, yet high-risk groups often maintain inadequate protection practices. Objectives: This study analyzed data from Italy's 2023 "Save Your Skin" campaign, which provided free skin checks nationwide. Methods: Data 1,773 participants across 29 centers in 13 regions were collected assess sun exposure, photoprotection habits, and awareness, identifying gaps efforts. Results: Most female (70.16%) with a median age...
Previous studies showed the efficacy of a formulation containing calcipotriol and betamethasone dipropionate for treatment psoriasis.To investigate maintenance strategies (50 µg/g) (0.5 mg/g) scalp psoriasis.Nine-hundred four patients were screened randomised on 1:1 basis in two groups: applications per week (group A) versus on-demand therapy B). Clinical evaluation was performed at weeks 0, 2, 4, 8 12.Eight-hundred eighty-five randomised: 441 group A 444 B. From both groups significant...
Phototherapeutic approach to dermatology patients during the
Abstract Background The pathogenic role of beta-HPVs in non melanoma skin cancer (NMSC), is not still completely understood, and literature data indicate that they might be at least cofactors the development certain cutaneous squamous cell carcinomas. However, only few reports contain on basal carcinoma (BCC). HPVs interact with many cellular proteins altering their function or expression levels, like p16 INK4a Akt. Our study aimed to determine presence different beta -HPV types Akt BCC,...
Patients with multiple actinic keratoses (AKs) should be treated field-directed therapy. Such treatments challenge patients' adherence due to out-of-pocket costs, length of treatment and severity local skin reactions (LSRs). Effective physician-patient communication (PPC) may buffer therapy-related distress, thus improving quality life, satisfaction adherence.We evaluated the interplay between PPC, LSR intensity (safety) lesion clearance rates (effectiveness) on satisfaction, life among...
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, accounting for 20% of all cutaneous malignancies, and has an increasing incidence in elderly as well younger population. Although cSCC treated with simple therapeutic procedures, advanced can lead a significant risk morbidity, negative impact on quality life, death. Proper management includes distinguishing between high-risk low-risk lesions determining treatment accordingly. A collaboration multidisciplinary...
Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, the development innovative therapies, incidence mortality increase annually. Major clinical factors for include fair skin, an increased number nevi, presence dysplastic family history melanoma. However, several external inducers seem to be associated with susceptibility such as environmental exposure, primarily unprotected sun experience, alcohol...
Summary Paired cultures of early‐passage melanoma cells and melanocytes were established from metastatic lesions the uninvolved skin five patients. In this stringent autologous setting, cDNA profiling was used to analyze a subset 1477 genes selected by Gene Ontology term ‘immune response’. Human Leukocyte Antigen E ( HLA‐E ) ranked 19th among melanoma‐overexpressed embedded in transformation signature including its preferred peptide ligand donors HLA‐A , HLA‐B HLA‐C HLA‐G . Mostly...
Background: Photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) is effective for the treatment of photoaging. Objective: To evaluate efficacy and safety PDT using a novel 0.5% liposome-encapsulated 5-ALA spray an intense pulsed light (IPL) system (Ellipse Flex PPT) in reduction periorbital nasolabial wrinkles. Patients Methods: Thirty healthy volunteers, aged 35–65 years, skin type I–III, 2 photoaging underwent baseline visit, three ALA-IPL treatments once every 3 weeks,...
Abstract Background Melanoma incidence/mortality is increasing worldwide. “ E uromelanoma D ay” a pan‐European campaign for skin cancer prevention. Results of the 2010 ay in I taly are reported herein. Materials and methods A questionnaire was used to collect data on participants' characteristics suspected cancers. Result total 1085 participants screened (64.1% females, median age 44 years). Suspicion rate, detection positive predictive values melanoma were 1.3, 0.28 21.4%, respectively....
Surgery is the therapy of choice in guidelines to treat basal cell carcinomas (BCCs) but a variety non-surgical options are available. The objective this study evaluate efficacy and safety ingenol mebutate 0.05% gel for treatment superficial BCCs. We accepted twenty patients with BCCs on body we treated them once daily two consecutive days gel. examined lesions at screening visit after four from application describe local skin reaction due therapy. Then followed six months first visit. All...
A high percentage of patients with thin melanoma (TM), defined as lesions Breslow thickness ≤1 mm, presents excellent long-term survival, however, some develop metastases. Existing prognostic factors cannot reliably differentiate TM at risk for metastases.We aimed characterizing the clinical-pathologic and mutation profile metastatic not-metastatic in order to distinguish metastases.Clinical-pathologic characteristics were recorded cases analyzed. We used a Next Generation Sequencing (NGS)...