A5018495576- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Dermatology and Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Autoimmune Bullous Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Neuropathies and Disorders
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cutaneous lymphoproliferative disorders research
- Pharmaceutical studies and practices
- Mast cells and histamine
- COVID-19 Impact on Reproduction
- Biosimilars and Bioanalytical Methods
- Skin Diseases and Diabetes
- Nail Diseases and Treatments
- Hidradenitis Suppurativa and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Psychosomatic Disorders and Their Treatments
- Dermatological and COVID-19 studies
San Gallicano Hospital
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Creative Research Enterprises (United States)
2016
University of Rome Tor Vergata
2011-2013
Sapienza University of Rome
2008
Purpose of the article: Interleukin-23 inhibitors, such as tildrakizumab, have emerged safe and effective options for management psoriasis. Yet their efficacy in elderly patients (aged 65 years or more), particularly those with difficult-to-treat areas involvement, remains insufficiently explored. We conducted this real-life retrospective multicentric observational study to assess effectiveness tildrakizumab moderate-to-severe psoriasis, involvement areas.Materials methods: enrolled...
Psoriasis is a common skin disease that affects quality of life, especially mental health. Alexithymia has been considered relevant feature in psoriasis patients. Moreover, was found to be associated with negative psychological health, including anxiety and depression. As the pathways linking alexithymia health remain unclear among patients psoriasis, we aimed examine mediating role depression relationship between these patients.To explore our variables interest, used Toronto Scale (TAS-20),...
Several new biologic agents targeting IL23/Th17 axis, such as risankizumab, have been developed for the treatment of psoriasis. The aim present study was to analyze efficacy and safety risankizumab in patients with moderate-to-severe psoriasis over a 52-week period. A multicentric retrospective conducted who initiated between July 2019 December 2020. Psoriasis Area Severity Index-PASI measured at baseline after 4, 16, 28 52 weeks. Clinical responses were evaluated by PASI75, PASI90 PASI100...
Among the most recent biologic drugs available for psoriasis therapy, those targeting interleukin-17 (secukinumab and ixekizumab) or its receptor (brodalumab) have been shown to be quickly effective. However, in patients who failed one more of above-cited drugs, real-life data on effectiveness switching anti-interleukin-23 (guselkumab, risankizumab, tildrakizumab) are very scarce. Here, we report our experience treating 12 multi-failure psoriatic patients, prospectively followed-up over 6...
We investigated a possible correlation between brain excitability in children with migraine and tension-type headache (TTH) their behavioural symptomatology, assessed by using the Child Behaviour Checklist (CBCL). The mismatch negativity (MMN) P300 response were recorded three successive blocks to test amplitude reduction of each from first third block (habituation). MMN habituation was significantly lower migraineurs TTH than control subjects (two-way ANOVA: P < 0.05). In migraineurs,...
Psoriasis has not been directly linked to a poor prognosis for COVID-19, yet immunomodulatory agents used its management may lead increased vulnerability the dangerous complications of SARS-CoV-2 infection, as well impair effectiveness recently introduced vaccines. The three-dose antibody response trend and safety BNT162b2 mRNA vaccine in psoriasis patients treated with biologic drugs have remained under-researched. Forty-five psoriatic on treatment were enrolled evaluate their humoral three...
The data in the literature concerning frequency of remission inflammatory arthritis patients with psoriatic (PsA) are limited and conflicting.To evaluate clinical a cohort PsA receiving continuous treatment (1 year) tumour necrosis factor-α inhibitors or ustekinumab, as well covariates affecting remission.We retrospectively evaluated 74 attending our psoriasis outpatient dermatology clinic. Remission was defined documented absence signs related to (no tender swollen joints), enthesitis...
Among patients undergoing follow-up after surgery for melanoma, ultrasound (US) very often reveals lymph nodes in groin area, that do not show clear characters of a metastatic lesion yet have atypical US features, which could result diagnostic uncertainty. We evaluated such lesions among cohort patients.The study population consisted who presented consecutively to our facility control between 1 January 2009 and 30 July 2010 had undergone at least 6 months earlier, areas draining the but...
The inflammatory involvement of the enthesis in course psoriasis is accompanied by structural abnormalities detectable ultrasound. most common these thickening tendon at insertion site.The aim present study was to compare thickness entheses patients with psoriatic arthritis, only skin psoriasis, and healthy controls.A cross-sectional conducted a cohort affected either or arthritis as well control group. Eight sites were scanned ultrasound bilaterally. following entheseal characteristics...
Background The recent introduction of biological drugs specifically targeting the interleukins involved in psoriasis pathogenesis revolutionized therapeutic scenario moderate to severe forms psoriasis. Among these, risankizumab, an anti-IL-23, was shown be effective both clinical trials and real-life experiences. However, data on its use very psoriasis, defined by a Psoriasis Area Severity Index (PASI) at least 30, are scant. In this context, our study aimed investigate outcomes patients...