A5027650355- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Food Allergy and Anaphylaxis Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nail Diseases and Treatments
- Asthma and respiratory diseases
- Skin and Cellular Biology Research
- Platelet Disorders and Treatments
- Dermatological and Skeletal Disorders
- Body Image and Dysmorphia Studies
- Tumors and Oncological Cases
- Eosinophilic Disorders and Syndromes
- Dermatological diseases and infestations
- Hair Growth and Disorders
- Whipple's Disease and Interleukins
- Historical and Environmental Studies
- Laser Applications in Dentistry and Medicine
- Oral and Craniofacial Lesions
- Therapeutic Uses of Natural Elements
- Biosimilars and Bioanalytical Methods
- Dermatologic Treatments and Research
- Spondyloarthritis Studies and Treatments
Istituto Dermopatico dell'Immacolata
2007-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2003-2024
Ospedale Sandro Pertini
2024
Fatebenefratelli Hospital
2006
IRCCS Policlinico San Donato
2003
Several new biologic agents targeting IL23/Th17 axis, such as risankizumab, have been developed for the treatment of psoriasis. The aim present study was to analyze efficacy and safety risankizumab in patients with moderate-to-severe psoriasis over a 52-week period. A multicentric retrospective conducted who initiated between July 2019 December 2020. Psoriasis Area Severity Index-PASI measured at baseline after 4, 16, 28 52 weeks. Clinical responses were evaluated by PASI75, PASI90 PASI100...
Background: Functional autoantibodies against the α ‐chain of high‐affinity IgE receptor (Fc ɛ RI ) identify a subset patients with chronic urticaria (CU) due to autoreactivity, as assessed by an in vivo positive response autologous serum skin test (ASST). We performed study standardize serum‐induced basophil activation assay flow cytometry (FCM) using new tricolour method, assessing diagnostic performance this discriminating between ASST+ and ASST− CU patients. Methods: Sera 64 (22 42 CU)...
Chemokines play a central role in atopic eczema/dermatitis syndrome (AEDS). Interleukin 16 (IL-16) has been described as main cytokine involved CD4+ cell recruitment during inflammation. Recently the influx of lymphocytes related to up-regulation IL-16 AEDS skin lesions. Circulating beta-chemokines (Eotaxin and RANTES) were investigated children with correlate their presence severity disease. We also measured serum levels soluble CD30 (sCD30), marker Th2 immune responses disease...
Abstract Background IL‐23 inhibitors were recently approved for the treatment of skin psoriasis and psoriatic arthritis (PsA). Risankizumab, a humanized monoclonal antibody that specifically binds p19 subunit IL‐23, has proven effective on PsA in two randomized controlled trials. To date, only few real‐world data are available this topic. Methods Our study aimed to prospectively evaluate effectiveness risankizumab patients with setting. For purpose, both rheumatologic dermatologic...
Psoriasis (PS) is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation and altered differentiation. Atopic dermatitis (ATOD) inflammatory, pruritic eczematous disease frequently associated with respiratory atopy. These diseases are distinct immunologic abnormalities represent typical examples of complex triggered both genetic environmental factors, as demonstrated independent twin studies. Genome wide linkage studies have mapped susceptibility loci on several...
Abstract Background The association of multiple cutaneous granular tumors with systemic defects is extremely rare. To date, 14 cases have been described. Case report A 14‐year‐old boy presented nodular lesions on his arms and legs; facial dysmorphism joint hypermobility were also present. Histopathologic examination two nodules showed cell tumors. We review the literature regarding in children associated somatic genetic syndromes. Conclusions combination alterations other organs not only...
Bullous pemphigoid (BP) is an autoimmune blistering disease that targets the haemidesmosomal proteins, mainly BP180. Extracellular vesicles (EVs) have been demonstrated to carry tissue-specific autoantigens in setting of diseases and transplant organ rejection; this phenomenon was pathogenic implications correlate with rejection severity. The purpose study identify presence BP targeted blister fluid derived EVs. We isolated, by size exclusion chromatography, EVs from blisters BP-patients...
Introduction Efficacy of anti-TNF-a agents seems inferior to IL-17 and IL-23 inhibitors. Nevertheless, after biosimilars approval, anti TNF-a are recommended as first-line for psoriatic patients, economic reasons.Methods Predictive factors response or non-response adalimumab in bionaive patients who started (originator biosimilar) over 12 years 9 dermatologic centers Italy. Effectiveness was assessed with Psoriasis Area Severity Index (PASI75 PASI90) at weeks 12, 24 48. Multiple logistic...
Atrophia maculosa varioliformis cutis was described in 1918 by Heidingsfeld as a type of idiopathic noninflammatory macular atrophy typically occurring young individuals. Only 13 cases have been reported since the first description. Considering that atrophia can be mistaken for scarring and artifact dermatitis, it is important physicians to distinguish this condition. We report new case 5‐year‐old boy.
Background . Given the chronic relapsing, remitting course of psoriasis, data about long‐term effectiveness may be useful to assess maintenance clinical response over time. Objective To evaluate 2‐year drug survival risankizumab and identify any predictive factor discontinuation for ineffectiveness. Materials Methods A multicenter retrospective study was conducted in patients who initiated between July 2019 December 2020. PASI measured at baseline after 104 weeks. Any adverse event...
A large part of the world’s population suffers from Striae distensae (SD) or stretch marks, which create physical and psychological discomfort in people. We evaluate SD clinical improvement by using a non-ablative fractional Nd:YAP 1340 nm laser. The research was performed on 25 patients both sexes, with mean age 31 ± 13.09 years. Each patient underwent minimum 3 to maximum 4 treatments, an (1340 nm) medical device, every four weeks, 3- 6-month follow-up, these areas: back, abdomen, breast,...
Background: At the beginning of every dermatopathy, including alopecia areata, one can frequently encounter presence a stressful event or situation. We have analyzed factors that seem to conditioned onset areata in 180 patients between 5 and 16 years age. Patients Methods: In order elucidate whether not stress is cofactor for development this dermatological disease, we evaluated psychosocial reality particularly possible some events situations occurring within 6 months prior appearance fresh...
The role of autoimmune IgE responses in atopic dermatitis (AD) is highly debated. While targeting self-proteins has been extensively studied, induced by human-homologous exogenous molecular allergens (HEMAs) remains less understood.
Abstract Pemphigus vulgaris (PV) is an autoimmune intraepithelial bullous disease. Associations with the class II human leukocyte antigen ( HLA ) alleles and pemphigus have been described. Furthermore, association between single nucleotide polymorphism of ST18 gene has reported. We report two pairs siblings from unrelated Italian families affected by vulgaris, characterizing their genetic immunological profile. In order to assess background, HLA‐DQA1 , HLA‐DQB1 HLA‐DRB1 a relevant were...