A5026940603- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pancreatic and Hepatic Oncology Research
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Dermatological and Skeletal Disorders
- Systemic Lupus Erythematosus Research
- Cutaneous lymphoproliferative disorders research
- Systemic Sclerosis and Related Diseases
- Cutaneous Melanoma Detection and Management
- Monoclonal and Polyclonal Antibodies Research
- Genetic and rare skin diseases.
- Dermatologic Treatments and Research
- Autoimmune and Inflammatory Disorders
- Dermatological and COVID-19 studies
- Nonmelanoma Skin Cancer Studies
- Parvovirus B19 Infection Studies
- Platelet Disorders and Treatments
- Dermatological diseases and infestations
- Cancer Genomics and Diagnostics
- melanin and skin pigmentation
- Urological Disorders and Treatments
- Ancient Mediterranean Archaeology and History
- Peripheral Neuropathies and Disorders
Ospedale Policlinico San Martino
2015-2025
University of Genoa
2016-2025
Department of Medical Sciences
2023
Vita-Salute San Raffaele University
2023
Hôpital Saint-Louis
2018
Istituti di Ricovero e Cura a Carattere Scientifico
1992-2017
Ospedale Maggiore
1995
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1995
University of Milan
1995
Bullous pemphigoid (BP) is an autoimmune bullous disease caused by circulating autoantibodies toward the hemidesmosomal antigens BP180 and BP230. Cases of BP have been described following vaccinations against tetanus, poliomyelitis, diphtheria, influenza, pneumococcus, meningococcus, hepatitis B rabies. The putative mechanism which COVID-19-vaccines may induce has not clarified. An Italian multicentre study was conducted to collect clinical, histopathological immunopathological data patients...
Worldwide, 500 million people a year acquire sexually transmitted disease (STD). Adolescents, accounting for 25% of the active population, are most affected. To analyze sexual behavior among Italian adolescents and their knowledge STDs, with goal preventing transmission, questionnaire was administered to 2867 secondary school students (1271 males 1596 females) aged 14-21 years. For study, 1492 were interviewed in Genoa (Northern Italy) 1375 Lecce (Southern Italy). 37% respondents, parents...
<title>Abstract</title> Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent environmental pollutants, recognized as carcinogens to the human body and associated with increased cancer risk, particularly in occupationally exposed workers. This study aims collect database evaluate dermal exposure PAHs among workers at an Italian coke plant investigate possible correlation development skin cancer. epidermal pads were applied 166 during work shift quantified deposition different...
Bullous pemphigoid, mucous membrane and pemphigus vulgaris are different cutaneous autoimmune blistering diseases, with complex pathogenic mechanisms. In all of them, a type-2 response is thought to have central role. Interleukin 4 13 crucial cytokines in response. Treatment these conditions often challenging. Dupilumab, recombinant fully human IgG4 monoclonal antibody binding specificity interleukin-4 receptor IL-4Rα, has the potential inhibit both IL-4 IL-13. We propose IL-4Rα as...
Artificial intelligence (AI) is reshaping healthcare, using machine and deep learning (DL) to enhance disease management. Dermatology has seen improved diagnostics, particularly in skin cancer detection, through the integration of AI. However, potential AI automating immunofluorescence imaging for autoimmune bullous diseases (AIBDs) remains untapped. While direct (DIF) supports diagnosis, its manual interpretation can hinder efficiency. The use DL classify DIF patterns automatically,...
Topical ivermectin is an anti-inflammatory and anti-Demodex drug for papulopustular rosacea. Rosacea a relapsing disease the time between recurrences should be considered alongside efficacy.The aims of this study were to assess first relapse rates Demodex mite infestation rosacea.We conducted prospective subjects affected by different degrees Patients that achieved complete response after treatment monitored every 4 weeks up 32 additional weeks. For each patient, we evaluated recording rate...
Linear IgA bullous dermatosis (LABD) is characterized by presence of multiple autoantibodies, and a comparatively lesser number IgG antibodies, directed against different hemidesmosomal antigens. The main autoantigens are LAD-1, LABD-97, BP180 BP230, type VII collagen laminin 332. We retrospectively studied the serology 54 Italian patients with LABD using enzyme-linked immunosorbent assay (ELISA), immunoblotting assay, indirect immunofluorescence on monkey oesophagus salt-split skin. Among...
OPINION article Front. Immunol., 18 February 2022Sec. Autoimmune and Autoinflammatory Disorders Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.834316
Dermatological emergencies exist and should not be underestimated. On the other hand, many accesses to emergency department (ED) of patients with dermatological conditions are unjustified.Our main objective is describe seen in an ED observation unit (EDOU). Secondly, our aim identify alarm symptoms signs 'true emergencies'.We conducted a prospective study, including admitted EDOU University Hospital San Martino, Genoa, Italy, 3 years.Overall 372 were studied. The most common condition was...
Abstract Actinic keratoses (AKs) are common dysplastic lesions resulting from chronic excessive ultraviolet exposure. Neither the clinical grade of thickness nor histological dysplasia seems valid predictors aggressive potential AKs. Instead, mutational status in AKs appears to predict well course. TP53 gene mutations result a non-functional protein resistant degradation, thus immunohistochemical staining for p53 can suggest mutation status. Increased was associated with progression AK...