A5081906669- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Hedgehog Signaling Pathway Studies
- Cutaneous lymphoproliferative disorders research
- Genetic and rare skin diseases.
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Allergic Rhinitis and Sensitization
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Dermatological and COVID-19 studies
- Tumors and Oncological Cases
- Infectious Diseases and Mycology
- CAR-T cell therapy research
- Skin Protection and Aging
- Fungal Infections and Studies
- Asthma and respiratory diseases
- melanin and skin pigmentation
- Sarcoma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Body Image and Dysmorphia Studies
- Genital Health and Disease
- Dermatological diseases and infestations
- Cell Image Analysis Techniques
University of Naples Federico II
2016-2025
Federico II University Hospital
2012-2023
Marconi University
2020
Central Michigan University
2020
Michigan United
2020
University of Salerno
2020
University of Campania "Luigi Vanvitelli"
2020
Systematic (Netherlands)
2006
Istituto Ortopedico Gaetano Pini
2001
Azienda Ospedaliera G.Rummo
2000
Background: The treatment of hidradenitis suppurativa (HS) has always been a real challenge for dermatologists; to date, adalimumab the only biologic drug approved HS is adalimumab, an anti-tumor necrosis factor (TNF)-α drug, approval this dates 2015, data provided by life show effectiveness rate about 60% percent. Recently (31 October 2023) FDA approves secukinumab moderate-severe HS. and management very challenging as available treatments are limited variable outcomes. Methods: We...
Background: It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized patients with may an increased risk developing certain types cancer. The efficacy safety biologic drugs are well-documented clinical trials real-life studies. However, there limited evidence on use treatments cancer psoriasis, this therapeutic class pre-existing or concomitant malignancy still...
Anti-programmed cell death 1 (PD1) is the first-choice treatment in patients with advanced cutaneous squamous carcinoma (cSCC), when curative options are unavailable. However, reliable biomarkers for patient selection still lacking. In this translational study, clinical annotations, tissue and liquid biopsies were acquired to investigate association between sustained objective responses transcriptional profiles, immune dynamics tumor peripheral blood samples, as well circulating cytokine...
<h3>Objective</h3> To investigate patterns of detection and variables associated with early diagnosis melanoma in a population at intermediate risk. <h3>Design</h3> Survey. <h3>Setting</h3> Hospital university centers belonging to the Italian Multidisciplinary Group on Melanoma. <h3>Patients</h3> Eight hundred sixteen patients who were consecutively diagnosed as having treated 11 participating centers. <h3>Main Outcome Measure</h3> Relationship between patient's physician's delay thickness,...
Background Benign melanocytic skin lesions may be difficult to differentiate from melanoma both clinically and dermoscopically. One of the most confounding dermoscopic features, commonly seen in but our experience also naevi, is represented by so-called blue–white structures (BWS). Objectives To evaluate diagnostic significance histopathological correlates BWS dermoscopy a series equivocal that were excised. Methods Patients recruited six specialized pigmented lesion clinics Austria, Italy...
Epiluminescence microscopy (ELM, skin surface microscopy, dermoscopy, dermatoscopy) is a valuable method for improving the diagnostic accuracy in pigmented lesions. Specific ELM criteria are already recognized differentiating Spitz naevi (PSN) from cutaneous melanomas (CM). Our purpose was to describe appearance of series PSN with emphasis on and CM overlapping features. Thirty-six consecutive patients PSN, three cases (selected larger database) exhibiting 'spitzoid' features, were evaluated...
Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas.To describe dermoscopic features SK-like melanomas to understand their clinical morphology.This observational retrospective study used 134 images histopathologically proven patients treated 9 skin cancer centers Spain, France, Italy, Austria. Without knowledge definite for all lesions...
Background Generalized prurigo nodularis (GPN) is a debilitating, inflammatory skin disease characterized by chronic pruritus, signs of prolonged scratching, and multiple pruriginous papules nodules. Recent studies identified several forms GPN as clinical phenotype adult atopic dermatitis (AD). Objective The aim the study was to evaluate effectiveness dupilumab (D) in adults affected persistent AD showing feature GPN. Methods A retrospective performed on patients with variant AD, treated D...
Special populations (SPs) involve people who require additional consideration in clinical research. Effectiveness of treatment or occurrence side effects may be different SPs with respect to not-SPs.To retrospectively compare the effectiveness and safety dupilumab AD versus not-SPs.A 52-weeks retrospective study was performed enrolling patients a diagnosis moderate-to-severe undergoing at labeled dosage. Patients were divided Group A (SPs patients) B (not-SPs patients). Disease severity...
Dupilumab is a monoclonal antibody approved for the treatment of moderate-to-severe atopic dermatitis (AD) in patients aged ≥12 years. Large, double-blind, randomized, placebo-controlled trials showed its efficacy and safety adolescents. However, real-life data are few. The aim this monocentric retrospective observational study (December 2020-November 2021) was to assess effectiveness dupilumab AD adolescents treated at least 24 weeks. For each patient demographic features, clinical adverse...
To determine the time required to perform a complete skin examination (CSE) as means of opportunistic screening for cancer both without and with dermoscopy.Randomized, prospective multicenter study.Eight referral pigmented lesion clinics. Patients From June 2006 January 2007, 1359 patients at least 1 melanocytic or nonmelanocytic were randomly selected receive CSE dermoscopy dermoscopy. For each patient, total number lesions duration recorded. A 1328 eligible analysis (31 excluded because...
Superficial basal cell carcinoma (BCC) presents as a scaly, pink to red-brown patch and is predominantly located on the trunk. Clinical diagnosis may not be always easy implicates variety of differential diagnoses; in this situation dermoscopy has been reported improving diagnostic accuracy. This study investigated dermoscopic patterns superficial BCC focalizing most specific frequent structures order improve accuracy.Study population referred skin lesion clinic.Dermoscopic 42 BCCs were...