A5059610917- Gastric Cancer Management and Outcomes
- Cutaneous Melanoma Detection and Management
- Helicobacter pylori-related gastroenterology studies
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Polyomavirus and related diseases
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Colorectal Cancer Surgical Treatments
- Melanoma and MAPK Pathways
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Dietary Effects on Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroblastoma Research and Treatments
- Appendicitis Diagnosis and Management
- Cancer-related Molecular Pathways
- Meningioma and schwannoma management
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Neuroendocrine Tumor Research Advances
- Endoplasmic Reticulum Stress and Disease
- Infectious Diseases and Mycology
University of L'Aquila
1993-2023
San Salvatore Hospital
1998-2023
Background Benign melanocytic skin lesions may be difficult to differentiate from melanoma both clinically and dermoscopically. One of the most confounding dermoscopic features, commonly seen in but our experience also naevi, is represented by so-called blue–white structures (BWS). Objectives To evaluate diagnostic significance histopathological correlates BWS dermoscopy a series equivocal that were excised. Methods Patients recruited six specialized pigmented lesion clinics Austria, Italy...
The endocannabinoid (eCB) system has gained ground as a key modulator of several female fertility-related processes, under physiological/pathological conditions. Nevertheless, its modulation during reproductive aging remains unclear. This study aimed to investigate the expression levels main receptors (cannabinoid receptor 1,CB1; cannabinoid 2, CB2; G-protein coupled receptor, GPR55; and transient potential vanilloid type 1 channel, TRPV1) metabolic enzymes (N-acylphosphatidylethanolamine...
Approximately 25% of melanoma patients with locoregional metastases are nonresponsive to new molecular target therapy and immunotherapy. When located in the pelvis, melphalan hypoxic perfusion can be an optional treatment. Because methylation MGMT promoter increases efficacy alkylating agents, studies on outcome treated regional chemotherapy should consider this epigenetic change. This study aims evaluate whether survival stage III may correlated status. The metastatic tissues 27 pelvis...
Single pelvic schwannomas are rare tumor arising from the retrorectal, lateral or obturatory space. Laparoscopic approach to schwannoma located in space has been previously described only one case report. We present a of successful laparoscopic resection emphasizing advantages such minimal invasive approach.A 54-years-old, obese, male patient was admitted our hospital referring dysuria and strangury. Abdominal CT scan showed well-circumscribed mass with smooth regular margins. A CT-guided...
Extradural spinal mass lesions are most commonly metastatic tumors. meningiomas rare, accounting for approximately 2.5-3.5% of meningiomas; intraoperatively, they easily mistaken malignant tumors, especially in the en plaque variety, resulting inadequate surgical treatment.Our case is one first to describe a patient with two purely extradural meningiomas, each between D3-D4 and D5-D6 vertebral levels. Surgical resection was radical, pathologically both were...
4-Aminobiphenyl (4-ABP)-DNA adducts and p53 overexpression were evaluated in laryngeal biopsies from 38 patients by immunohistochemical methods. Samples categorized as tumors (n = 9), polyps 28) or normal tissue 1). 4-ABP-DNA with a quantitative immunoperoxidase method using monoclonal antibody 3C8 both the lesion adjacent tissue. Relative staining intensity data showed log-normal distribution values found smokers significantly higher (median: 173.5, geometric mean: 159.9) than those...
Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that increasing in incidence and have poor survival rates. The majority caused by genomic polyomavirus (MCPyV) integration MCPyV T-antigen expression. Recently, a potential oncogenic role for the tropomyosin-related tyrosine kinase A receptor (TrkA) has been proposed MCC. Alternative TrkAIII splicing is TrkA activation mechanism can be promoted SV40 large T-antigen, an analogue of T-antigen. In this...
Pelvic Melanoma relapse occurs in 15% of patients with loco regional metastases, and 25% cases do not respond to new target-therapy and/or immunotherapy. Melphalan hypoxic pelvic perfusion may, therefore, be an option for these non-responsive patients. Overall median survival time (MST), stratified variables, including BRAF V600E mutation eligibility treatments immunotherapy drugs, was retrospectively assessed 41 melanoma metastases. They had received a total 175 cytoreductive excision....
Post-therapeutic relapse, poor survival rates and increasing incidence justify the search for novel therapeutic targets strategies in cutaneous malignant melanoma (CMM). Within this context, a potential oncogenic role TrkA CMM is suggested by reports of NTRK1 amplification, enhanced expression intracellular activation associated with prognosis. TrkA, however, exhibits tumour-suppressing properties cell lines has recently been reported not to be progression. To better understand these...
Abstract Background Neuroendocrine tumors (NETs) are heterogeneous, widely distributed arising from neuroendocrine cells. Gastrointestinal (GI)-NETs the most common and NETs of rectum represent 15, 2% gastrointestinal malignancies. Poorly differentiated carcinomas GI tract uncommon. We report a rare case poorly locally advanced rectal carcinoma with nodal subcutaneous metastasis, cytoplasmic staining positive for Synaptophysin Thyroid Transcription Factor-1. Case presentation A 72-year-old...
In this study, the effects of aging and parity on VEGF-A/VEGFR protein content signaling in mice ovaries were determined. The research group consisted nulliparous (virgins, V) multiparous (M) during late-reproductive (L, 9-12 months) post-reproductive (P, 15-18 stages. Whilst ovarian VEGFR1 VEGFR2 remained unchanged all experimental groups (LM, LV, PM, PV), VEGF-A phosphorylated significantly decreased only PM ovaries. VEGF-A/VEGFR2-dependent activation ERK1/2, p38, as well cyclin D1, E1,...
Merkel cell carcinoma (MCC) is a rare, neuroendocrine skin tumor, with high frequency of locoregional recurrence, metastases, and poor prognosis. Locoregional MCC recurrence in the extremities can pose considerable treatment challenges. We report case long-term survival female patient recurrent leg, treated surgery chemotherapy.A 73-year-old cirrhosis hepatitis C, developed cutaneous left inferior limb. This initially received surgical treatment, subsequent negative sentinel lymph-node...
Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which caused by the genomic integration polyomavirus (MCPyV). MCPyV-positive MCCs carry poor prognosis in 70% cases, highlighting need for greater understanding oncogenic mechanisms involved pathogenesis, progression and post-therapeutic relapse, translation into novel therapeutic strategies. In a previous pilot study, we reported potential relationship between MCPyV gene expression...
Extra-anastomotic intraluminal recurrence of the colon cancer after curative surgery was rarely reported but ileal relapse has not been described to date.We report a case tumor arising right hemicolectomy that could be ascribed an implantation exfoliated cells.A 71-years old man admitted with no metastatic stenotic adenocarcinoma hepatic flexure and submitted, without preoperative bowel preparation, using "no-touch" technique. Histology showed moderately differentiated lymph nodes...
Gastric cancer (GC) represents one of the most important causes death by malignancy world wide. Our retrospective study was carried out on surgical stomach specimens obtained from a series 552 consecutive cases GC observed in Departments Surgical Pathology Public Hospitals L'Aquila and Atri which cover 17% entire population Italian Region Abruzzo. The aim to compare anatomo-clinical characteristics early (EGC) advanced (AGC).The diagnosis achieved criteria Lauren's histopathological...