A5067910775- Synthesis and pharmacology of benzodiazepine derivatives
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis and Reactivity of Heterocycles
- Cutaneous Melanoma Detection and Management
- Microscopic Colitis
- Inflammatory Bowel Disease
- Drug Transport and Resistance Mechanisms
- Chemical synthesis and pharmacological studies
- Coordination Chemistry and Organometallics
- Cancer therapeutics and mechanisms
- Nuclear physics research studies
- Inflammatory mediators and NSAID effects
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Sarcoma Diagnosis and Treatment
- Environmental Toxicology and Ecotoxicology
- Effects and risks of endocrine disrupting chemicals
- Anesthesia and Pain Management
- Synthesis and Biological Evaluation
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Assays
- Neutrino Physics Research
- Mercury impact and mitigation studies
University of Naples Federico II
1992-2025
Sapienza University of Rome
1989-2023
Policlinico Umberto I
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2018-2022
University of Salerno
2022
University of Rome Tor Vergata
2022
University of L'Aquila
1996-2017
Federico II University Hospital
2014
University of Molise
2014
Ospedale "Santa Maria delle Croci" di Ravenna
1992
Journal Article Effects of Maternal Exposure to Polychlorobiphenyls (PCBs) on F1 Generation Behavior in the Rat Get access GIANCARLO PANTALEONI, PANTALEONI Search for other works by this author on: Oxford Academic PubMed Google Scholar DONATELLA FANINI, FANINI 2 3To whom correspondence should be addressed ANNA MARIA SPONTA, SPONTA PALUMBO, PALUMBO RAFFAELE GIORGI, GIORGI PERRIE M. ADAMS *The University Texas Health Science CenterDallas, Toxicological Sciences, Volume 11, Issue 1, 1988, Pages...
The consumption of fresh tomatoes and processed tomato products is widespread in the Mediterranean diet. This fruit a valuable source antioxidants plays an important role preventing oxidative stress. study aimed to investigate content measure total antioxidant capacity (ABTS DPPH assays) peel, pulp, seed fractions six cultivars. Finally, some bioactive compounds activity were also determined homemade purees, since such production commonplace Southern Italy. level each fraction calculated...
Aim : To measure mucosal concentrations of mesalazine in ulcerative colitis patients treated with oral alone, compared to both topical and mesalazine. Methods Twenty‐two mild moderate were randomized receive 2.4 g/day (11 patients) or plus 4 patients). After 2 weeks treatment, endoscopic biopsies specimens taken from the rectum descending colon just distal splenic flexure stored –80 °C for later assay (HPLC). Wilcoxon’s rank sum test unpaired data was used statistical analysis. Results...
Mercury (Hg) is a global environmental pollutant that affects human and ecosystem health. With the aim of exploring Hg-induced protein modifications, intact erythrocytes were exposed to HgCl
A high-performance liquid chromatographic method was developed, validated and applied to the simultaneous determination of 5-aminosalicylic acid (5-ASA) its acetylated metabolite (acetyl-5-ASA) in human plasma. The involves liquid-liquid extraction with methanol followed by isocratic reversed-phase chromatography on a Kromasil KR100 C(18) column electrochemical detection. recovery, selectivity, linearity, precision accuracy were evaluated from spiked plasma samples. effects mobile phase...
The presence of tin in gunshot residue (GSR) particles from ammunitions used short and long rifled firearms is well known widely documented. Tin does not originate the primer mixture itself but typically linked to a thin disc-shaped foil placed over mercury fulminate-based primers prevent embrittlement cartridge case cap. However, this practice has been previously reported or observed hunting ammunitions. We designed an experimental protocol investigate formation quaternary GSR containing...
Approximately 25% of melanoma patients with locoregional metastases are nonresponsive to new molecular target therapy and immunotherapy. When located in the pelvis, melphalan hypoxic perfusion can be an optional treatment. Because methylation MGMT promoter increases efficacy alkylating agents, studies on outcome treated regional chemotherapy should consider this epigenetic change. This study aims evaluate whether survival stage III may correlated status. The metastatic tissues 27 pelvis...
To investigate how long and much Mesalazine (M) is available inside the rectal mucosa following its topical instillation, in patients (pts) with Ulcerative Colitis (UC). Two biopsies for M concentration were obtained from 45 UC pts clinical remission on oral treatment (OT), before a 4g enema randomly given to consentient every day (Group A, 15 pts), 2 days B, pts) 3 C, pts). additional taken 1, after last group B C respectively, at least 10 later. All immediately frozen -80°C later assay by...
Chromium (VI) is the most dangerous oxidation state among stable forms of chromium. In this work, we evaluated effect exposing Mytilus galloprovincialis for 24 h to 1, 10, and 100 nM chromium on properties Protamine-like (PLs) their gene levels in gonads. Specifically, analyzed, by AU-PAGE SDS-PAGE, PLs extracted from unexposed exposed mussels. addition, via EMSA, ability bind DNA also verified potential protect oxidative damage. Finally, assessed possible alterations gonadal expression...
Background : Surgical resection of Crohn’s disease is followed by early recurrence in a high percentage patients. Mesalazine has been shown to be effective the prevention post‐operative recurrence, but some 50% patients under treatment recur at 3 years follow‐up. Aim To establish whether mucosal concentration mesalazine might affect development recurrence. Methods Colon‐ileoscopy was performed 25 consecutive resected for disease. The mean time from surgery 14 months. After operation, all...
<h3>Hypothesis</h3> To evaluate the role of hypoxic pelvic perfusion in providing therapeutic options for palliation without relevant complications a homogeneous group patients with unresectable locally recurrent rectal cancer who are nonresponders or have disease progression after standard treatments. <h3>Design</h3> Nonrandomized and noncontrolled phase II experimental study. <h3>Setting</h3> University hospital, L'Aquila, National Cancer Institute, Naples Milan, Italy. <h3>Patients</h3>...
This pilot study was conducted to evaluate the advantage in drug delivery for regional chemotherapy patients with unresectable recurrent rectal carcinoma by different methods. For this research, pharmacokinetic advantages of mitomycin C four methods were compared: intraaortic infusion aortic stopflow; inferior vena cava and caval vein stopflow (hypoxic pelvic perfusion); hypoxic perfusion hemofiltration. The results indicate that followed significantly increases concentrations blood coming...
A 44‐week clinical study was carried out on a large sample of the Italian infant population to measure incidence diaper (napkin) dermatitis and identify factors related development dermatitis. Factors such as age, sex, presence atopic dermatitis, general state health child, use drugs type used were recorded. At end test, 2169 dermatological examinations performed. The frequency episodes 15.2%. Statistical correlations between conditions found.
Abstract A simple high‐performance liquid chromatographic (HPLC) method with photometric detection is described for the determination of vardenafil hydrochloride, a phosphodiesterase V inhibitor, in human plasma. Chromatographic separation analyte and internal standard was achieved on an analytical 250 × 4.6 mm i.d. reversed‐phase Kromasil KR 100 C 18 (5 µm particle size) column using mobile phase acetonitrile–potassium dihydrogen phosphate (30:70 v/v). The run time less than 15 min. Column...
The reaction Be(p7,γ)8B plays an important role in the Sun, where it determines high energy component of solar neutrino spectrum. importance this triggered several experiments over last decades. A combined analysis their results produces overall consistent picture for dependence cross section, while inflation quoted uncertainties is needed to accommodate observed discrepancy absolute scale different data sets. origin needs be understood a reliable estimate astrophysical rate and its...
Abstract Background Isolated pelvic perfusion (IPP) can be used to treat unresectable melanoma metastases of the pelvis. IPP performed either by surgical or percutaneous approaches, using different balloon catheters. The aim this study was examine whether and approaches were comparable with respect tumor drug exposure in Methods A pharmacokinetic 5 patients treated five IPP. Both groups received melphalan at dose 30 mg/m 2 . Melphalan analyses main parameter evaluate drug-exposure ratio...
Abstract A simple and precise high-performance liquid procedure has been developed for the determination of Ofloxacin (DL-8280), a new oxazine derivative in human serum, urine bile using Norfloxacin as internal standard. The work-up involves chemical extraction step followed by isocratic chromatography on anion-exchange analytical column, with ultraviolet detection. run time assay was 11.5 minutes.