A5101784604- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Infectious Diseases and Mycology
- Cancer and Skin Lesions
- Nail Diseases and Treatments
- Tumors and Oncological Cases
- Optical Coherence Tomography Applications
- Syphilis Diagnosis and Treatment
- Skin Protection and Aging
- Actinomycetales infections and treatment
- Cancer Genomics and Diagnostics
- Reproductive tract infections research
- Dermatological and COVID-19 studies
- Comparative constitutional jurisprudence studies
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Skin and Cellular Biology Research
- Advancements in Transdermal Drug Delivery
- Autoimmune and Inflammatory Disorders
- Musculoskeletal synovial abnormalities and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2024
Hospital Clínic de Barcelona
2013-2024
Universitat de Barcelona
2012-2024
Melanoma Institute Australia
2022
Centro de Investigación Biomédica en Red
2019-2020
Centre for Biomedical Network Research on Rare Diseases
2016-2019
Macquarie University
2017
Instituto de Salud Carlos III
2016
Abstract Advancements in dermatological artificial intelligence research require high-quality and comprehensive datasets that mirror real-world clinical scenarios. We introduce a collection of 18,946 dermoscopic images spanning from 2010 to 2016, collated at the Hospital Clínic Barcelona, Spain. The BCN20000 dataset aims address problem unconstrained classification skin cancer, including lesions hard-to-diagnose locations such as those found nails mucosa, large which do not fit aperture...
Melanomas that clinically mimic seborrheic keratosis (SK) can delay diagnosis and adequate treatment. However, little is known about the value of dermoscopy in recognizing these difficult-to-diagnose melanomas.To describe dermoscopic features SK-like melanomas to understand their clinical morphology.This observational retrospective study used 134 images histopathologically proven patients treated 9 skin cancer centers Spain, France, Italy, Austria. Without knowledge definite for all lesions...
Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value dermoscopy to improve correct detection these mimickers has not been previously studied.To evaluate diagnostic accuracy clinically SK-like MMs with without dermoscopy.Clinical dermoscopic images histopathologically proven (n = 134) intermingled other benign tumors were randomly presented clinicians different levels experience, blinded goal study. Each...
Many follow‐up guidelines for patients with high‐risk melanoma include expensive imaging studies, serum biomarkers and regular visits to the dermatologist, little attention cost‐effectiveness. To establish cost‐effectiveness of chest–abdomen–pelvis computed tomography (CT) brain magnetic resonance (MRI) in a protocol at high risk relapse. This was prospective single‐centre cohort study 290 clinicopathological American Joint Committee on Cancer (AJCC) stage IIB, IIC III melanoma. Patients had...
Given recent developments in the treatment of metastatic melanoma, early detection disease recurrence is crucial. The aim this single-centre retrospective cohort study was to investigate impact initial stage primary melanoma on pattern and timing post-recurrence survival. Patients diagnosed with cutaneous IA-IIID, between January 1996 December 2018 who developed until May 2019 were included (n = 784). Earlier at diagnosis associated a higher proportion locoregional lower distant metastasis...
The rosette structure is a dermoscopic sign visible under polarized light, characterized by 4 white points arranged as 4-leaf clover. It has been mainly described in facial sun-damaged skin and actinic keratosis, although it also found squamous basal cell carcinomas, 2 cases of hypomelanotic melanomas. We describe different pigmented incipient melanomas with the presence multiple rosettes shiny structures on dermoscopy. In reflectance confocal microscope they exhibit disarranged epidermal...
In vivo reflectance confocal microscopy (RCM) enables the study of architectural and cytological aspects in horizontal sections, which closely correlate with histologic features. However, traditional histopathological vertical sections cannot totally reproduce image RCM section.To evaluate concordance between histopathologic transverse for melanocytic lesions, basal cell carcinoma seborrheic keratoses.Prospectively collected benign non-melanocytic tumours diagnosed by dermoscopy were...
Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.To report our experience of initial evaluation and follow-up in this peculiar subset vulvar using reflectance confocal microscopy (RCM).We retrospectively evaluated 18 consecutive cases referred for atypical pigmentation or which melanoma was considered that underwent both RCM examination histopathological assessment. In 13 with available dermoscopic pictures, classification compared to diagnosis, all...
Women have a better melanoma prognosis, and fairer skin/hair colour. The presence of inherited MC1R variants has been associated with but its interaction sex is unknown.To evaluate the relationship between germline status survival, determine any association sex.This was cohort study including 1341 patients from Melanoma Unit Hospital Clinic Barcelona, January 1996 April 2018. We examined known sex-related prognosis factors as they relate to features evaluated sex-specific role in overall...
The p.V600E mutation in the BRAF protein is most frequent cutaneous melanoma and a recurrent alteration found common benign naevi. Analysis of cell‐free c.1799T>A, (cfBRAFV600E) plasma has emerged as biomarker for monitoring prognosis treatment response patients with melanoma. To quantify cfBRAFV600E levels from without undergoing regular follow‐up their melanocytic lesions, order to assess clinical significance test. We quantified by droplet digital polymerase chain reaction 146 continuous...
Several studies have suggested that naevus-associated melanomas differ from de novo melanomas, being thinner and with less ulceration; however, the prognostic implication is unclear. The objective of this study was to describe clinicopathological, genetic survival characteristics in a cohort primary invasive cutaneous over 20-year period. Of 2,227 patients included study, 509 (22.86%) had melanomas. Compared melanoma, they were younger, fairer phototype higher naevus count, tumours...
Malignant syphilis is an uncommon form of secondary associated with HIV infection. Clinically, it characterized by necrotic nodules and generalized ulcerated lesions. We present 4 cases malignant diagnosed after evaluating at our hospital between 2012 2016. describe the epidemiologic, clinical, histiopathologic, serologic characteristics explore its response to treatment association Although uncommon, there has been increase in number published recent years, particularly young HIV-positive...
Abstract Congenital melanocytic nevi (CMN) are cutaneous malformations whose prevalence is inversely correlated with projected adult size. CMN caused by somatic mutations, but epidemiological studies suggest that germline genetic factors may influence development. In patients from the U.K., variants in MC1R , such as p.V92M and loss‐of‐function variants, have been previously associated larger CMN. We analyzed association of characteristics two distinct cohorts medium‐to‐giant Spain ( N =...