A5046139419- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Oral Health Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Cervical Cancer and HPV Research
- Head and Neck Surgical Oncology
- Cell Adhesion Molecules Research
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Protease and Inhibitor Mechanisms
- Tumors and Oncological Cases
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Cleft Lip and Palate Research
Karolinska Institutet
2014-2023
Karolinska University Hospital
2014-2023
Stockholm County Council
2012
Linköping University
2012
Turku University Hospital
2012
Svenska Örtmedicinska Institute
2010
Sophiahemmet Hospital
1992-2009
University of Cincinnati Medical Center
1995
University of Zagreb
1995
Bispebjerg Hospital
1992
Abstract In the county of Stockholm, between 1970 and 2002, we have previously reported a 3‐fold parallel increase in incidence tonsillar squamous cell carcinoma (SCC) proportion human papillomavirus (HPV) positive SCC. Here, followed above parameters all patients ( n = 120) diagnosed with SCC during 2003–2007 same area, also correlation to our previous data. Ninety‐eight pretreatment biopsies were available presence HPV DNA HPV‐16 E6 E7 RNA tested by polymerase chain reaction (PCR) RT‐PCR....
Smoking and alcohol are well-known etiological factors in tonsillar cancer. However, as cervical cancer, human papillomavirus (HPV) is currently found a sizable proportion of Recent reports from the U.S. Finland show an increase incidence without parallel rise smoking consumption. This study investigates whether cancer has also changed Sweden possible explanation higher HPV-positive The between 1970 2002 Stockholm area was obtained Swedish Cancer Registry. In parallel, 203 pretreatment...
Human papillomavirus (HPV) is more commonly found in tonsillar cancer than other head and neck cancers. The importance of HPV status for prognosis remains unclear. aim the present study was to investigate frequency correlate presence with tumor stage, nodal status, grade differentiation, risk relapse, survival. DNA type were determined, using PCR, pre-treatment biopsies from 60 cases primary cancer. All patients had undergone full-dose radiotherapy, 45% as only treatment modality, 55%...
Abstract The aim of our study was to investigate the physical state and viral load HPV‐16 in tonsillar cancer correlate these findings with clinical outcome. To distinguish between integrated episomal forms HPV, 22 fresh‐frozen samples were analysed by a method based on restriction enzyme cleavage, ligation PCR ( rli PCR). detected 11/22 HPV‐33 1/22 cancers, hence 12/22 (55%) tumours HPV positive. Only extrachromosomal observed. Full‐length exclusively 7/11 whereas both full‐length deleted...
Abstract Numerous reports have shown that the incidence for oropharyngeal cancer is increasing and human papillomavirus (HPV) a risk factor. However, few studies investigated specific subsites of oropharynx. Following our previous research on tonsillar cancer, we assessed increase in base tongue prevalence HPV this disease. Between 1998 2007, 109 patients were diagnosed Stockholm county. Ninety‐five paraffin‐embedded diagnostic tumor biopsies from obtained tested HPV, both by general PCR...
From 1970 to 2002 in the Stockholm area, we revealed a parallel three‐fold increase incidence of tonsillar cancer and proportion human papillomavirus (HPV) positive cases, indicating possible role HPV infection this disease. We have now examined whether viral load pre‐treatment biopsies correlates disease prognosis, presence HPV‐16 E6 E7 mRNA could be ascertained. The HPV‐16, but not load, was shown favourable prognostic factor for clinical outcome. Moreover, and/or were expressed almost all...
Background Human papillomavirus (HPV) is a causative factor for tonsillar squamous cell carcinoma (TSCC) and patients with HPV positive (HPV+) TSCC have better clinical outcome than those negative (HPV−) TSCC. However, since not all HPV+TSCC respond to treatment, additional biomarkers are needed together status predict response therapy individualize treatment. For this purpose, we examined whether the number of tumor infiltrating cytotoxic regulatory T-cells in correlated outcome. Methods...
Abstract The frequency of human papilloma virus (HPV) and its influence on clinical outcome was analyzed retrospectively in pre‐treatment paraffin embedded biopsies from 110 patients with tongue cancer. presence HPV DNA examined 85 mobile tumors 25 base by a polymerase chain reaction (PCR) 2 general primer pairs, GP5+/6+ CPI/IIG. When HPV‐DNA found, HPV‐type specific primers direct sequencing were used for sub‐type verification. Twelve (10.9%) samples HPV‐positive; 9 HPV‐16, 1 HPV‐33, HPV‐35...
Conclusions: The incidence of tonsillar cancer in Sweden is increasing, particularly among men. Risk factors other than smoking may have contributed to the observed secular trend In women, however, can be a part explanation. Further studies look at changes environmental factors, such as human papilloma virus (HPV) infection, are clearly warranted. Objectives: Head and neck related habits has decreased substantially during last 30 years Sweden. However, there suspicion that increased it USA...
A growing body of evidence suggests that components the tumor microenvironment, including cancer-associated fibroblasts (CAF), may modulate treatment sensitivity cells. Here, we investigated possible influence CAFs on head and neck squamous cell carcinoma (HNSCC) lines to cetuximab, an antagonistic epidermal growth factor receptor (EGFR) antibody. Cetuximab caused a reduction in proliferation rate HNSCC lines, whereas HNSCC-derived CAF cultures was unaffected. When cells were cocultured with...
The incidence of base tongue cancer is increasing in Sweden and the proportion human papillomavirus (HPV) positive has increased Stockholm, Sweden. Between 2006 2007, 84% cases Stockholm were HPV-positive. objective this study was to assess impact HPV status on prognosis for patients. One-hundred nine patients diagnosed with between 1998 2007 County 95 paraffin-embedded diagnostic tumor biopsies obtained tested by PCR. Eighty-seven had available biopsies, treated intention cure could be...
Abstract Today, most oropharyngeal squamous cell carcinoma ( OSCC ) is human papillomavirus HPV positive and alone or in combination with p16 reported to be a favorable prognostic factor for . Patients tumors at other sites OOSCC are often included the same treatment study protocols as patients tonsillar‐ base of tongue SCC , even though prevalence clinical significance infection unknown. Since tonsillar SSC cover roughly 90% all there an obvious risk that may misinterpretation results...
Tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) has increased. In Stockholm, the proportion human papillomavirus (HPV)-positive cases incidence TSCC rose between 1970 2006 then stabilized. Here, HPV-prevalence, TSCC/BOTSCC 2000-2016, in Stockholm Sweden were followed.Incidence data for 2000-2016 obtained from Swedish Cancer Registry. biopsies, 2013-2016 examined HPV DNA p16INK4a , or medical reports. For 2000-2012, available previous studies.The continued to rise...
The concept of functional neutrophil subsets is new and their clinical significance in malignancies unknown. Our study investigated the role CD16dim CD62Lhigh, CD16high CD62Lhigh CD62Ldim head neck squamous cell carcinoma (HNSCC) patients. These may play different roles immune-related activity cancer, based on profile, activation state migration ability within a tumor site, which be important predicting cancer prognoses. Tumor biopsies blood were obtained from newly diagnosed untreated HNSCC...
HPV-DNA positive (HPVDNA+) oropharyngeal squamous cell carcinoma (OSCC) has better clinical outcome than negative (HPVDNA-) OSCC. Current treatment may be unnecessarily extensive for most HPV+ OSCC, but before de-escalation, additional markers are needed together with HPV status to predict response. Here the influence of HLA class I/HLA II expression was explored. Pre-treatment biopsies, from 439/484 OSCC patients diagnosed 2000-2009 and treated curatively, were analyzed I expression,...
Abstract Our aim was to map and compare genomic imbalances in human papillomavirus (HPV)‐positive ‐negative squamous cell carcinomas of the tonsil. Twenty‐five primary were analyzed by comparative hybridization. Fifteen (60%) found be HPV‐positive PCR, majority HPV‐16. There statistically significant differences distribution DNA gains losses between samples. Eleven 15 samples (73%) showed gain on chromosome 3q24‐qter, while only 4/10 (40%) HPV‐negative had same ( p = 0.049). Furthermore, but...
Abstract Patients with cancer of unknown primary ( CUP ) in the head neck region are generally treated dissection followed by radiotherapy at times combined chemotherapy, a treatment associated considerable side effects. Some these tumors may originate as human papillomavirus HPV )‐positive oropharyngeal squamous cell carcinoma OSCC ), better clinical outcome than HNSCC general, and could potentially do well less treatment. Here, we therefore investigated whether status p53‐expression...
Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer associated with poor prognosis. Methods for determining the aggressiveness of OTSCC from analysis primary tumour specimen are thus highly desirable. We investigated whether genomic instability and proliferative activity (by means Ki-67 activity) could be clinical use prediction locoregional recurrence in 76 pretreatment paraffin samples (stage I, n=22; stage II, n=33; III, n=8; IV, n=13). Eleven surgical specimens were also...