A5016570484- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Polyomavirus and related diseases
- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Nanoplatforms for cancer theranostics
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Neuroblastoma Research and Treatments
- Cardiac Structural Anomalies and Repair
- Meningioma and schwannoma management
- Acute Myeloid Leukemia Research
- Dermatological and Skeletal Disorders
- Renal function and acid-base balance
- Cancer Genomics and Diagnostics
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Tuberculosis Research and Epidemiology
- Cancer Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Diabetes Management and Research
- Liver Disease and Transplantation
- Congenital Diaphragmatic Hernia Studies
- Health, Medicine and Society
- Pituitary Gland Disorders and Treatments
Uppsala University Hospital
2022-2024
Science for Life Laboratory
2022-2024
Uppsala University
2017-2024
Falun Hospital
2023
University of Colorado Denver
2018
Children's Hospital Colorado
2018
Princess Máxima Center
2018
Institut Gustave Roussy
2016-2017
Karolinska Institutet
2004-2016
Karolinska University Hospital
2009-2014
Abstract In the county of Stockholm, between 1970 and 2002, we have previously reported a 3‐fold parallel increase in incidence tonsillar squamous cell carcinoma (SCC) proportion human papillomavirus (HPV) positive SCC. Here, followed above parameters all patients ( n = 120) diagnosed with SCC during 2003–2007 same area, also correlation to our previous data. Ninety‐eight pretreatment biopsies were available presence HPV DNA HPV‐16 E6 E7 RNA tested by polymerase chain reaction (PCR) RT‐PCR....
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, histomolecular characteristics between short-term survivors (STSs) long-term (LTSs). Materials Methods Data abstracted from registry databases included patients North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, United...
BK virus (BKV) load in urine alone or combination with acute graft-versus-host disease (GVHD) was correlated to development of hemorrhagic cystitis (HC). BKV GVHD discriminated the best, while and viral alone, but not GVHD, still showed predictive ability for HC.
Abstract Background Low-grade gliomas (LGGs) represent children’s most prevalent central nervous system tumor, necessitating molecular profiling to diagnose and determine the suitable treatment. Developing highly sensitive screening techniques for liquid biopsy samples is particularly beneficial, as it enables early detection characterization of tumors with minimally invasive samples. Methods We examined CSF plasma from patients pilocytic astrocytoma (PA) using custom multiplexed droplet...
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It therefore time for international collaboration DIPG research, to provide new hope children, parents medical professionals fighting DIPG. In first step towards collaboration, 2011, network biologists clinicians working the field was established within European...
BackgroundChildhood cancer predisposition (ChiCaP) syndromes are increasingly recognized as contributing factors to childhood development. Yet, due variable availability of germline testing, many children with ChiCaP might go undetected today. We report results from the nationwide and prospective study that investigated diagnostic yield clinical impact integrating whole-genome sequencing (gWGS) tumor systematic phenotyping in solid tumors.MethodsgWGS was performed 309 at diagnosis CNS (n =...
The single most important causative factor for malignant melanomas of the skin is UV radiation. However, this not true on body surfaces sheltered from sun; thus, it to seek new factors melanoma genesis. Human papillomaviruses and gammaherpesviruses are associated with human cancer; example, papillomavirus types 5 8 epidermodysplasia verruciformis, herpesvirus Kaposi's sarcoma. Recently, a newly described polyomavirus, Merkel cell polyomavirus (MCPyV), has been carcinoma, an unusual form...
Abstract Relapse is the leading cause of death in patients with medulloblastoma, most common malignant pediatric brain tumor. A better understanding mechanisms underlying recurrence could lead to more effective therapies for targeting tumor relapses. Here, we observed that SOX9, a transcription factor and stem cell/glial fate marker, limited rare, quiescent cells high-risk medulloblastoma MYC amplification. In paired primary-recurrent patient samples, SOX9-positive accumulated SOX9...
BK and JC polyomaviruses (BKV JCV) are potentially oncogenic have in the past inconclusively been associated with tumours of central nervous system (CNS), while BKV has hinted, but not confirmed to be neuroblastomas. Recently three new (KIPyV, WUPyV MCPyV) were identified humans. So far KIPyV human diseases, MCPyV was discovered Merkel Cell carcinomas may neuroepithelial cell tropism. However, all viruses can this compelled us investigate for their presence childhood CNS
Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on combination chemotherapy with cytarabine (ara-C) and anthracyclines. Five-year overall survival below 30%, which has partly been attributed to resistance. Preclinical data suggest that the addition hydroxyurea potentiates efficacy by increasing ara-C triphosphate (ara-CTP) levels through targeted inhibition SAMHD1.In this phase 1 trial, we evaluated feasibility, safety standard cytarabine/daunorubicin in AML patients.Nine...
Background: Neonatal dried blood spots (Guthrie cards) have been used to demonstrate a prenatal origin of clonal leukemia-specific genetic aberrations in several subgroups childhood acute lymphoblastic leukemia (ALL). One hypothesis suggests that an infectious agent could initiate transformation already utero. In search for possible viral agent, Guthrie cards were analyzed the presence 3 newly discovered polyomavirus Karolinska Institutet polymavirus (KIPyV), Washington University (WUPyV),...
Background: Neurological complications after allogeneic hematopoietic stem cell transplantation (HSCT) are associated with increased mortality. Reactivation of JC virus, a well-known human polyomavirus (HPyV), can be progressive multifocal leukoencephalopathy HSCT. Aim: To investigate whether reactivation the newly discovered HPyVs KIPyV, WUPyV, Merkel polyomavirus, HPyV6, HPyV7, trichodysplasia spinulosa HPyV9 or HPyV10 (MWPyV) is neurological Materials & methods: Cerebrospinal fluid from...
Abstract BACKGROUND Liquid biopsies (LBs) allow for analysis of tumour-derived molecules, such as cell-free DNA (cfDNA) and microRNAs (miRNAs), complementing cancer diagnostics, therapy monitoring, minimal residual disease detection. While circulation-based LB has benefit extracranial tumour entities, peripheral blood not historically been a reliable source diagnosis disease-monitoring in brain tumours. For these tumours, cerebrospinal fluid (CSF) is better suited detection despite being...
Medulloblastomas comprise a molecularly diverse set of malignant pediatric brain tumors in which patients are stratified according to different prognostic risk groups that span from very good poor. Metastasis at diagnosis is most often marker poor prognosis and the relapse incidence higher these children. Medulloblastoma almost always fatal recurring cells have, apart resistance standard care, acquired genetic epigenetic changes correlate with an increased dormancy state, cell state...
Abstract The transcription factor SOX9 is a stem cell and glial fate marker in the developing brain. levels correlate with worse prognosis relapse Group 3 medulloblastoma, malignant pediatric brain tumor poor survival. activation promotes epidermal to mesenchymal transition leptomeningeal spread. It also upregulated by facilitates cisplatin resistance medulloblastoma cells. Direct inhibition has proven difficult few targeted substances have emerged from drug screening efforts. acts as...
Abstract BACKGROUND We established patient-derived xenografts (PDXs) from matched primary-relapse pairs of pediatric high-grade gliomas (pedHGGs) in collaboration with the Swedish Childhood Tumor Biobank. Further, we used human iPSC derived cortical organoids to evaluate interactions between glial and tumor cells under treatment pressure potentially lost xenograft models. Using this setup, hope follow relapse evolution identify novel mechanisms behind evasion formation. METHODS Tumoral...
Abstract BACKGROUND Whole genome sequencing (WGS) is the most informative singular molecular assay in cancer diagnosis. Recent evidence demonstrates that WGS can add diagnostic information and change management of childhood cancer, thus being increasingly employed clinical settings globally. However, it remains unknown whether accurately recapitulate existing multi-assay standard-of-care (SOC) genomic testing used pediatric diagnostics. In this study we evaluate concordance between SOC...