A5028291333- Craniofacial Disorders and Treatments
- Spinal Dysraphism and Malformations
- Cleft Lip and Palate Research
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Fractures and Fixation Techniques
- Lysosomal Storage Disorders Research
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Spine and Intervertebral Disc Pathology
- Facial Trauma and Fracture Management
- Intraoperative Neuromonitoring and Anesthetic Effects
- Congenital Diaphragmatic Hernia Studies
- Infectious Diseases and Tuberculosis
- Cerebral Venous Sinus Thrombosis
- Connective tissue disorders research
- Bone Tumor Diagnosis and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Glycogen Storage Diseases and Myoclonus
- Vascular Malformations Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Oral and Maxillofacial Pathology
- Congenital Anomalies and Fetal Surgery
Birmingham Children's Hospital
2015-2024
Birmingham Women’s and Children’s NHS Foundation Trust
2022-2024
Salford Royal NHS Foundation Trust
2023
Birmingham Women's Hospital
2020-2022
University of Birmingham
2013-2022
Cancer Research UK Clinical Trials Unit
2022
University of Colorado Denver
2018
Princess Máxima Center
2018
Children's Hospital Colorado
2018
Swiss HIV Cohort Study
2016
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, histomolecular characteristics between short-term survivors (STSs) long-term (LTSs). Materials Methods Data abstracted from registry databases included patients North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, United...
PurposeApproximately two-thirds of patients with the lysosomal storage disease mucopolysaccharidosis II have progressive cognitive impairment. Intravenous (i.v.) enzyme replacement therapy does not affect impairment because recombinant iduronate-2-sulfatase (idursulfase) penetrate blood–brain barrier at therapeutic concentrations. We examined safety idursulfase formulated for intrathecal administration (idursulfase-IT) via drug delivery device (IDDD). A secondary endpoint was change in...
Insertion of a ventriculoperitoneal shunt for hydrocephalus is one the commonest neurosurgical procedures worldwide. Infection implanted affects up to 15% these patients, resulting in prolonged hospital treatment, multiple surgeries, and reduced cognition quality life. Our aim was determine clinical cost-effectiveness antibiotic (rifampicin clindamycin) or silver shunts compared with standard at reducing infection.In this parallel, multicentre, single-blind, randomised controlled trial, we...
Transarticular screws at the C1 to C2 level of cervical spine provide rigid fixation, but there is a danger injury vertebral artery. The risk related technical skill surgeon and variations in local anatomy. We studied grooves for artery 50 dry specimens second vertebra (C2). They were often asymmetrical, 11 one was deep enough reduce internal height lateral mass point fixation < or =2.1 mm, width pedicle on inferior surface =2 mm. In such specimens, placement transarticular screw would put...
To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years.A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using classical diagnostic criteria categorised according to 2013 revised criteria. We derived age, sex weight-specific annual incidence rates assessed effects weight categories.We identified 185...
Fronto-orbital advancement and remodeling for craniosynostosis is extensive surgery associated with potential risks; the most significant of these blood loss. We prospectively studied 116 consecutive patients undergoing fronto-orbital by same surgical team a 5-year 6-month period to determine what factors are loss transfusion products. The data collected on calvarial sutures involved were whether patient had diagnosed syndrome, age at operation, length estimated volume lost during...
With the need for transparency of surgical results, 30-day outcome measures have become increasingly important. Ventriculoperitoneal (VP) shunt failure is a substantial burden to patients and health care systems.This study introduces VP rate as possible barometer demonstrates its use in national (United Kingdom [UK]) makes comparison with 2 published randomized, controlled trials (RCT).A cohort all (except 1) pediatric neurosurgical centers UK Ireland. All new revision operations were...
Transarticular screws at the C1 to C2 level of cervical spine provide rigid fixation, but there is a danger injury vertebral artery. The risk related technical skill surgeon and variations in local anatomy. We studied grooves for artery 50 dry specimens second vertebra (C2). They were often asymmetrical, 11 one was deep enough reduce internal height lateral mass point fixation ≤2.1 mm, width pedicle on inferior surface ≤2 mm. In such specimens, placement transarticular screw would put...
To gain insight into the frequency, age of onset, and management cervical cord compression in mucopolysaccharidosis VI (MPS VI). Cervical spine magnetic resonance imaging (MRI) data and/or decompression surgery collected between 30 June 2005 1 September 2015 were analyzed from subjects enrolled MPS Clinical Surveillance Program (CSP) (ClinicalTrials.gov: NCT00214773), an ongoing multicenter, observational, retrospective prospective registry. Of 213 CSP, 134 (62.9%) had at least one...
The occurrence of cognitive impairment and behavioral problems in patients with metopic synostosis has been described. relationship between the severity incidence speech language delays not established. Twenty nonsyndromic isolated were evaluated. Five different preoperative measurements (metopic angle at roof orbit, lateral orbital wall sella, cranial indices, distances medial walls walls) taken from computed tomography compared results postoperative assessments. Frontal advancement...
There is some uncertainty as to when normal fusion of the metopic suture occurs. Existing studies have included relatively small numbers and not used a statistical model represent any variation in normality. In this study, total 337 head computed tomographic scans performed between 2006 2009 were retrospectively reviewed after strict exclusion criteria met. Only patients aged younger than 18 months included. Assessment was by analyzing axial slices bony window scan 2 independent...
The use of posterior calvarial distraction (PCD) for the management craniosynostosis is well recognized. advantages using this technique include increased cranial volume, decreased intracranial pressure, relief fossa crowding, improved cerebrospinal fluid (CSF) circulation at cranio-cervical junction with cessation, and possible resolution syrinx.The authors retrospectively review their first 50 patients who have undergone PCD under senior author's care in our unit.The demographics,...
Aims To determine the incidence of unintended medication discrepancies in paediatric patients at time hospital admission; evaluate process medicines reconciliation; assess benefit reconciliation preventing clinical harm. Method A 5 month prospective multisite study. Pharmacists four English hospitals conducted admission children using a standardised data collection form. discrepancy was defined as difference between patient's preadmission (PAM), compared with initial orders written by...
Computerized anatomic reconstruction of the dry axis vertebra was performed to determine radiologic guidelines for safe superior transarticular screw trajectory.To reconstruct trajectory, using computer-aided design techniques, and develop a technique that provides real-time intraoperative guidance during placement.A recent osteometric study 50 specimens noted significant vertebral artery groove anomalies in 22% specimens. There are presently no or help surgeons avoid an enlarged groove,...
Nearly all children with MPS IVA develop skeletal deformities affecting the spine. At atlanto-axial spine, odontoid hypoplasia occurs. GAG deposition around dens, leads to peri-odontoid infiltration. Transverse/alar ligament incompetence causes instability. Atlanto-axial instability is associated cord compression and myelopathy, leading major morbidity mortality. Intervention often required. Does presence of widened bullet shaped vertebra in platyspondily encroach on spinal canal cause...